Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

Activity: Talk or presentationOral presentation


Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping a multi-cellular tumor spheroid in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles quantified. Our experiments reveal that nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.
Period13 Nov 2018
Event title22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Event typeConference
Conference number22
SponsorsASE Group, Industrial Technology Research Institute (ITRI), KLOE, QuantaMatrix, Inc., Zeon Corporation
LocationKaohsiung, TaiwanShow on map
Degree of RecognitionInternational


  • Multi-cellular Tumor spheroid
  • Ultrasound
  • Microbubbles
  • Nanomedicine