Enhancing nanomedicine penetration in tumor-on-a-chip models using ultrasound-mediated microbubble activation

A.M. Bokkers (Contributor), J.-B. Blondé (Contributor), I. Lentacker (Contributor), Versluis, M. (Contributor), Lajoinie, G. (Contributor), le Gac, S. (Speaker)

Activity: Talk or presentationOral presentation

Description

Here, we report on ultrasound mediated microbubble activation for efficient and deep delivery of nanomedicines in co-culture multicellular tumor spheroids (MCTS), in a microfluidic chip. Specifically, a tumor-on-a-chip platform was realized by trapping a multi-cellular tumor spheroid in a microfluidic chamber. Microbubbles and nanoparticles, used as models for nanomedicines, were perfused continuously, the microbubbles were activated by ultrasound and the penetration of the nanoparticles quantified. Our experiments reveal that nanoparticle penetration sites coincide with the initial positions of the microbubbles around the spheroids.
Period13 Nov 2018
Held at22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018
Event typeConference
Conference number22
LocationKaohsiung, Taiwan, Province of China
Degree of RecognitionInternational

Keywords

  • Multi-cellular Tumor spheroid
  • Ultrasound
  • Microbubbles
  • Nanomedicine