What Controls Endothelial Sprouting? Interstitial Flow vs. Shear Stress

Nasim Salehi Nik (Speaker), Sayedeh Sana Sayedipour (Contributor), Prasanna Padmanaban (Contributor), Fabian Stein (Contributor), Rouwkema, J. (Contributor)

Activity: Talk or presentationOral presentation

Description

During angiogenesis, endothelial cell (EC) sprouting occurs when select ECs lining a vessel are exposed to stimulatory factors. Growth factor gradient has been proved to stimulate angiogenesis. However, the effect of shear stress on cell sprouting has been controversial. Since certain level of media perfusion is required to support cell viability as well as to maintain the stability of the newly formed vascular network, it is necessary to fine-tune shear stress in engineered tissues. In the present study, we investigated the effect of different amounts of shear stress and interstitial flow on EC sprouting with the aim of finding a new approach to control vascular formation in thick engineered tissues.
Period30 May 2019
Degree of RecognitionInternational