This is the droplet trajectory data for the article 'Towards realistic simulations of human cough: Effect of droplet emission duration and spread angle. International Journal of Multiphase Flow, 103883'. The numerical simulation was conducted using AFiD code with point-particle model. The two .h5 files correspond to the 0° and 45° spread angle cases, respectively. The data can be imported to MATLAB using the code attached. Descriptions of the variables can also be found in the code.