Research Output

2020

Development of double porous poly (ε - caprolactone)/chitosan polymer as tissue engineering scaffold

Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P., 1 Feb 2020, In : Materials Science and Engineering C. 107, 110257.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion

Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T., 31 Oct 2020, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019. Basel, Switzerland: Chemical and Biological Microssytems Society, p. 1530-1531

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

E-learning on the lab with lab education software: Deeper learning & more efficiency?

Vreman-De Olde, G. C., Rouwenhorst, C., Alers, J. C. & van der Veen, J. T., 1 Jan 2020, Varietas delectat... Complexity is the new normality: SEFI 47th Annual Conference Proceedings. Nagy, B. V., Murphy, M., Jarvinen, H-M. & Kalman, A. (eds.). Societe Europeenne pour la Formation des Ingenieurs (SEFI), p. 1261-1270 10 p. (SEFI 47th Annual Conference: Varietas Delectat... Complexity is the New Normality, Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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6 Downloads (Pure)

Improving Organ on‐Chip Physiology: Exploring the barrier in blood‐brain barrier on‐chip systems

Tibbe, M. P., 31 Jan 2020, Enschede: University of Twente. 169 p.

Research output: ThesisPhD Thesis - Research UT, graduation UT

Open Access
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35 Downloads (Pure)
2019

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
348 Downloads (Pure)

A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells

Komen, J., Westerbeek, E. Y., van der Meer, A. & van den Berg, A., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

A platform for assessing pro- and anti-arrhythmic effects of drugs based on isogenic human iPSC-derived cardiomyocytes

Campostrini, G., Sala, L., Ward-van Oostwaard, D., van Meer, B. J., Tertoolen, L. G. J., Bartulos-Encinas, O., Braam, S. R., IJzerman, A. P., Mummery, C. L. & Bellin, M., Sep 2019, In : Acta physiologica. 227, S718, p. 159-160 e13366.

Research output: Contribution to journalMeeting AbstractAcademic

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
23 Downloads (Pure)

Asessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip

Avgidis, F., Tibbe, M. P., Leferink, A. M. & Segerink, L., 2019, Microtas 2019.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood

Albers, H. J., Passier, R., van den Berg, A. & van der Meer, A. D., 14 Nov 2019, In : Micromachines. 10, 11, 781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Downloads (Pure)

Developing microfluidic tooling for 3D cell-culture

Loessberg-Zahl, J. T., 20 Dec 2019, Enschede: University of Twente. 166 p.

Research output: ThesisPhD Thesis - Research UT, graduation UT

Open Access
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130 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
26 Downloads (Pure)

Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications

de Pinho, A. R. G., Odila, I., Leferink, A., van Blitterswijk, C., Camarero-Espinosa, S. & Moroni, L., 25 Sep 2019, In : Frontiers in bioengineering and biotechnology. 7, SEP, 231.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
10 Downloads (Pure)

Investigation into the molecular complexity of Alzheimer's disease: an amyloid-ß centered approach

Cioffi, F., 20 Sep 2019, Enschede: University of Twente. 320 p.

Research output: ThesisPhD Thesis - Research UT, graduation UT

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Cioffi, F., Adam, R. H. I. & Broersen, K., 12 Dec 2019, In : Journal of Alzheimer's Disease. 72, 4, p. 981-1017 37 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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6 Downloads (Pure)

Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function

Zakharova, M., van der Helm, M., Palma Do Carmo, M., Le The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L., 2019.

Research output: Contribution to conferencePoster

Native cardiac environment and its impact on engineering cardiac tissue

Schwach, V. & Passier, R., 1 Sep 2019, In : Biomaterials Science. 7, 9, p. 3566-3580 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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1 Citation (Scopus)
6 Downloads (Pure)

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
40 Downloads (Pure)

Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis

Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A. & Barrile, R., 1 Oct 2019, In : Current Opinion in Toxicology. 17, p. 1-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
21 Downloads (Pure)

Scalable microphysiological system to model three-dimensional blood vessels

de Graf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., Mummery, C. L. & Orlova, V. V., 21 Jun 2019, In : APL Bioengineering. 3, 2, 026105.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Downloads (Pure)

Shape-defined solid micro-objects from poly(D,L-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering

Leferink, A. M., Tibbe, M. P., Bossink, E. G. B. M., de Heus, L. E., van Vossen, H., van den Berg, A., Moroni, L. & Truckenmüller, R. K., Sep 2019, In : Materials Today Bio. 4, 100025.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
18 Downloads (Pure)

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

van Meer, B. J., Krotenberg, A., Sala, L., Davis, R. P., Eschenhagen, T., Denning, C., Tertoolen, L. G. J. & Mummery, C. L., 20 Sep 2019, In : Nature communications. 10, 1, 9 p., 4325.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
13 Downloads (Pure)

Standardized, modular microfluidic building blocks for automated cell culturing systems

Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A. & Odijk, M., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Diettrich, P., Delamarche, E. & Hierlemann, A. (eds.). 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society, p. 86-87 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Downloads (Pure)

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance

Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P., Dec 2019, In : Tissue Engineering - Part A. 25, 23-24, p. 1635-1645 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems

Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., 9 Jul 2018, In : Alternatives to Animal Experimentation. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
44 Downloads (Pure)

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R. & Sarro, P. M., 24 Apr 2018, 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. IEEE, Vol. 2018-January. p. 318-321 4 p. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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26 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
84 Downloads (Pure)

Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

Devalla, H. D. & Passier, R., 4 Apr 2018, In : Science Translational Medicine. 10, 435, eaah5457.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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10 Citations (Scopus)
40 Downloads (Pure)

Differentiation and validation of human iPSC-derived atrial cardiomyocytes

Sutton, K., El Haou, S., Williams, S., Devalla, H., Stoelzle-Feix, S., Juhasz, K., Doerr, L., Beckler, M., Haarmann, C., George, M., Passier, R., Fertig, N. & Rogers, M., 13 Sep 2018, In : Journal of Pharmacological and Toxicological Methods. 93, p. 168-168 176.

Research output: Contribution to journalMeeting AbstractAcademic

Evolution of the Proximal Sealing Rings of the Anaconda Stent-Graft After Endovascular Aneurysm Repair

Koenrades, M. A., Klein, A., Leferink, A. M., Slump, C. H. & Geelkerken, R. H., 1 Aug 2018, In : Journal of Endovascular Therapy. 25, 4, p. 480-491 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Citations (Scopus)
76 Downloads (Pure)

Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices

Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A. & Eijkel, J. C. T., 11 Nov 2018, MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, G-B. & F-G. T. (eds.). The Chemical and Biological Microsystems Society, p. 2239-2241 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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1 Downloads (Pure)

Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices

Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., Orlova, V. V. & van der Meer, A. D., 11 Nov 2018, MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Tseng, F-G. & Lee, G-B. (eds.). The Chemical and Biological Microsystems Society, p. 2392-2393

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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2 Downloads (Pure)

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

Tertoolen, L. G. J., Braam, S. R., van Meer, B. J., Passier, R. & Mummery, C. L., 18 Mar 2018, In : Biochemical and biophysical research communications. 497, 4, p. 1135-1141 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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15 Citations (Scopus)
63 Downloads (Pure)

Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes

Le-The, H., Tibbe, M., Loessberg-Zahl, J., Palma Do Carmo, M., van der Helm, M., Bomer, J., Van Den Berg, A., Leferink, A., Segerink, L. & Eijkel, J., 28 Apr 2018, In : Nanoscale. 10, 16, p. 7711-7718 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
96 Downloads (Pure)

Membranes for Organs-on-Chips

Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D. & Segerink, L., 2018, Biomedical Membranes and (Bio)Artificial Organs. Stamatialis, D. (ed.). World Scientific, p. 295-321

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
91 Downloads (Pure)

Micro-structured membrane as a 3D biodegradable scaffold: development, characterization and cell-matrix interaction

Das, P., 14 Dec 2018, Toulouse: Université Fédérale Toulouse Midi-Pyrénées. 124 p.

Research output: ThesisPhD Thesis - Research external, graduation UT

Open Access
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5 Downloads (Pure)

Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., Mosqueira, D. & 7 others, Orlova, V. V., Passier, R., Catarino Ribeiro, M., Saleem, U., Smith, G. L., Burton, F. L. & Mummery, C. L., 2 Feb 2018, In : Circulation research. 122, 3, p. e5-e16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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26 Citations (Scopus)
55 Downloads (Pure)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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48 Citations (Scopus)
21 Downloads (Pure)

Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips

Vollertsen, A. R., Dekker, S., Wesselink, B. A. M., Haverkate, R., Bomer, J. G., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., van der Meer, A., Passier, R., van den Berg, A. & Odijk, M., 11 Nov 2018, MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Tseng, F-G. & Lee, G-B. (eds.). The Chemical and Biological Microsystems Society, p. 2199-2201 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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68 Downloads (Pure)

The Next Chapter for Stem Cell Reports

Mummery, C., 11 Dec 2018, In : Stem cell reports. 11, 6, p. 1303-1304 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

2017

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1765-1779 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
40 Downloads (Pure)

A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array

Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J. & van der Meer, A. D., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 1013 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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1 Downloads (Pure)

A multiplexed organ-on-chip device with individually addressable channels

Palma Do Carmo, M., van der Helm, M. W., van der Meer, A., van den Berg, A., Eijkel, J. C. T. & Segerink, L., May 2017.

Research output: Contribution to conferencePoster

Chipholder-integrated 3d-printed pneumatic logic controllers for microfluidic chips

Loessberg-Zahl, J., Vollenbroek, J., van der Meer, A., Eijkel, J. & van den Berg, A., 22 Oct 2017, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 645 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS(; vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery

Gümüscü, B., Albers, H. J., Van Den Berg, A., Eijkel, J. C. T. & Van Der Meer, A. D., 1 Dec 2017, In : Scientific reports. 7, 3381.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
54 Downloads (Pure)