Research Output

2017

Configurable gel geometry via flow patterning for angiogenisis assays

Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J. & van den Berg, A., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & D. D. (eds.). The Chemical and Biological Microsystems Society, p. 1074- 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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1 Downloads (Pure)

Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip

van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., van der Meer, A., Eijkel, J., Ingber, D. E., van den Berg, A. & Segerink, L., 24 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). Chemical and Biological Microstystems Society, p. 1114-1115 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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13 Downloads (Pure)

Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M., 12 May 2017, In : Journal of visualized experiments. 2017, 123, e55587.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
128 Downloads (Pure)
Open Access
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6 Citations (Scopus)
87 Downloads (Pure)

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

Giacomelli, E., Mummery, C. L. & Bellin, M., 1 Oct 2017, In : Cellular and Molecular Life Sciences. 74, 20, p. 3711-3739 29 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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17 Citations (Scopus)
82 Downloads (Pure)

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1754-1764 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
76 Downloads (Pure)

Human Ventricular Stem Cell Cardiomyocytes: Validating In Vitro Assays and Screening Platforms for Pro-arrhythmia Risk Prediction

Rogers, M., Ridley, J., El-Haou, S., Williams, S., Webdale, L., Sutton, K., Stoelzle-Feix, S., Thomas, U., Fertig, N., Zwetsloot, T., Devalla, H. D. & Passier, R., 2017, In : Journal of Pharmacological and Toxicological Methods. 88, 2, p. 241-241 0237.

Research output: Contribution to journalMeeting AbstractOther research output

InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility

Harris, K., Rossman, E., Xu, X., Clements, P., Mannhardt, I., Hansen, A., Saleem, U., Eschenhagen, T., Hortigon, M., Rodriguez, V. Z., Smith, G., van Meer, B., Tertoolen, L., Mummery, C., Catarino Ribeiro, M., Passier, R., de Korte, T., Vlaming, M., Braam, S., Vickers, C. & 5 others, Mosqueira, D., Firth, K., Prodanov, L., George, V. & Denning, C., 2017, In : Journal of Pharmacological and Toxicological Methods. 88, 2, p. 238-238 0227.

Research output: Contribution to journalMeeting AbstractOther research output

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

Sala, L., Bellin, M. & Mummery, C. L., 1 Nov 2017, In : British journal of pharmacology. 174, 21, p. 3749-3765 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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45 Citations (Scopus)
122 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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27 Citations (Scopus)
91 Downloads (Pure)

Modelling and drug screening for cardiovascular disease

Passier, R., Mar 2017, In : Acta physiologica. 219, S711, p. 7-7 SO2-2.

Research output: Contribution to journalSpecial issueAcademicpeer-review

1 Downloads (Pure)

Organs-on-chips for vascular function

van der Meer, A., 20 Oct 2017, In : Toxicology Letters. 280, 1, p. S29 1 p.

Research output: Contribution to journalSpecial issueAcademicpeer-review

7 Citations (Scopus)
1 Downloads (Pure)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L., 2017, In : Biochemical and biophysical research communications. 482, 2, p. 323-328 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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54 Citations (Scopus)
60 Downloads (Pure)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L., 15 Mar 2017, In : Development (Cambridge). 144, 6, p. 1008-1017 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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63 Citations (Scopus)
40 Downloads (Pure)

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., Orlova, V. V. & 6 others, Passier, R., Ribeiro, M. C., Saleem, U., Smith, G. L., Mummery, C. L. & Burton, F. L., 2017, bioRxiv.

Research output: Working paper

Open Access
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57 Downloads (Pure)
2016

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors

den Hartogh, S. C., Wolstencroft, K., Mummery, C. L. & Passier, R., 19 Jan 2016, In : Scientific reports. 6, 19386.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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21 Citations (Scopus)
45 Downloads (Pure)

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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47 Citations (Scopus)
44 Downloads (Pure)

Challenges of immaturity and proliferation in using hPSC-derived cardiomyocytes as disease models

Mummery, C., Birket, M., van Meer, B., Ribeiro, M., Passier, R., Bellin, M., Orlova, V., Davis, G. R., Freund, C., Kosmidis, G. & Tertoolen, L., Nov 2016, In : Human Gene Therapy. 27, 11, p. A11-A11 INV38.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
218 Downloads (Pure)

Complex Tissue and Disease Modeling using hiPSCs

Passier, R., Orlova, V. V. & Mummery, C., 3 Mar 2016, In : Cell stem cell. 18, 3, p. 309-321 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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60 Citations (Scopus)
95 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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34 Citations (Scopus)
273 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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119 Citations (Scopus)
51 Downloads (Pure)

Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity

den Hartogh, S. C. & Passier, P. C. J. J., 23 Nov 2016, In : Stem cells. 34, 1, p. 13-26

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
11 Downloads (Pure)

Generation and purification of human stem cell-derived cardiomyocytes

Schwach, V. & Passier, R., 1 Apr 2016, In : Differentiation. 91, 4-5, p. 126-138 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

12 Citations (Scopus)
2 Downloads (Pure)

Go with the flow: humane stamcellen in vasculair onderzoek

Mummery, C. L., 10 Mar 2016, Enschede: Universiteit Twente. 13 p.

Research output: Book/ReportInaugural speechOther research output

Open Access
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45 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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93 Citations (Scopus)
113 Downloads (Pure)
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158 Downloads (Pure)

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K-L. & Sinnecker, D., 2016, In : European heart journal. 38, 4, p. 292–301

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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34 Citations (Scopus)
50 Downloads (Pure)

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., Kutalik, Z. & 9 others, de Vries, A. A. F., Rivard, L., Wilde, A. A. M., Talajic, M., Verkerk, A. O., Al-Gazali, L., Rioux, J. D., Bhuiyan, Z. A. & Passier, R., 1 Dec 2016, In : EMBO molecular medicine. 8, 12, p. 1390-1408 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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28 Citations (Scopus)
16 Downloads (Pure)

Ultra-thin nanochannel-based liquid TEM cell for EELS analysis and high resolution imaging

Arik, Y. B., Matsui, R., Sarajlic, E., Takayama, Y., Boom, B. A., Berenschot, J. W., le Gac, S., Tas, N. R. & Fujita, H., 24 Jan 2016, 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, p. 804-807

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Waar het hart vol van is

Passier, P. C. J. J., 10 Mar 2016, Enschede: Universiteit Twente. 20 p.

Research output: Book/ReportInaugural speechOther research output

Open Access
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141 Downloads (Pure)
2015

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure

Kosmidis, G., Bellin, M., Ribeiro, M. C., van Meer, B., Ward-van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S., 27 Nov 2015, In : Biochemical and biophysical research communications. 467, 4, p. 998-1005 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Studying the blood-brain barrier on a microfluidic chip

McKim, J. M. (ed.), van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2015.

Research output: Contribution to conferencePaper

Studying the blood-brain barrier on a microfluidic chip

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., Dec 2015, p. 313-314. 2 p.

Research output: Contribution to conferenceAbstract

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44 Downloads (Pure)