Research Output 2015 2019

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2019
3 Citations (Scopus)
263 Downloads (Pure)

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Induced Pluripotent Stem Cells
Blood Vessels
Technology
Microfluidics
Pharmaceutical Preparations
2 Downloads (Pure)

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Apolipoproteins E
HDL Lipoproteins
Agglomeration
Apolipoprotein E4
Lipids
1 Citation (Scopus)
12 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Hydrogel
Hydrogels
Gels
Technology
1 Citation (Scopus)
11 Downloads (Pure)

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dielectric Spectroscopy
Electric Impedance
Acoustic impedance
Cells
Spectroscopy
6 Citations (Scopus)
5 Downloads (Pure)

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Precision Medicine
Medicine
Physiology
Testing
Cell culture
2018
8 Citations (Scopus)
21 Downloads (Pure)

Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems

Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., 9 Jul 2018, In : Alternatives to Animal Experimentation. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
39 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
organs
chips
Tissue
Cells
Equipment Design
1 Citation (Scopus)
60 Downloads (Pure)

Evolution of the Proximal Sealing Rings of the Anaconda Stent-Graft After Endovascular Aneurysm Repair

Koenrades, M. A., Klein, A., Leferink, A. M., Slump, C. H. & Geelkerken, R. H., 1 Aug 2018, In : Journal of Endovascular Therapy. 25, 4, p. 480-491 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Boidae
Stents
Aneurysm
Transplants
Endoleak
11 Citations (Scopus)
46 Downloads (Pure)

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

Tertoolen, L. G. J., Braam, S. R., van Meer, B. J., Passier, R. & Mummery, C. L., 18 Mar 2018, In : Biochemical and biophysical research communications. 497, 4, p. 1135-1141 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Toxicity
Screening
8 Citations (Scopus)
26 Downloads (Pure)

Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes

Le-The, H., Tibbe, M., Loessberg-Zahl, J., Palma Do Carmo, M., Van Der Helm, M., Bomer, J., Van Den Berg, A., Leferink, A., Segerink, L. & Eijkel, J., 28 Apr 2018, In : Nanoscale. 10, 16, p. 7711-7718 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polydimethylsiloxane
Membranes
Fabrication
Photoresists
Sulfur Hexafluoride
32 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Cells
Fabrication
Endothelial cells
Physiology
13 Citations (Scopus)
22 Downloads (Pure)

Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., Mosqueira, D. & 7 othersOrlova, V. V., Passier, R., Catarino Ribeiro, M., Saleem, U., Smith, G. L., Burton, F. L. & Mummery, C. L., 2 Feb 2018, In : Circulation research. 122, 3, p. e5-e16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Muscle Contraction
Cardiac Myocytes
Myocardium
Software
Pluripotent Stem Cells
11 Citations (Scopus)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD40 Ligand
Thrombosis
Monoclonal Antibodies
Thrombin
Platelet Activation
32 Citations (Scopus)
4 Downloads (Pure)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Thrombosis
Lung
Microfluidics
Endothelium
Therapeutics
2017
8 Citations (Scopus)
28 Downloads (Pure)

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1765-1779 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ovalbumin
Stem cells
Cardiac Myocytes
Transcription Factors
Pluripotent Stem Cells
4 Citations (Scopus)
38 Downloads (Pure)
Open Access
File
Caco-2 Cells
Microfluidics
Hydrogel
Cell Culture Techniques
Perfusion
5 Citations (Scopus)
65 Downloads (Pure)

Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M., 12 May 2017, In : Journal of visualized experiments. 2017, 123, e55587.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Electrodes
Induced Pluripotent Stem Cells
5 Citations (Scopus)
54 Downloads (Pure)
Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Fabrication
Equipment and Supplies
10 Citations (Scopus)
61 Downloads (Pure)

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1754-1764 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cell Differentiation
Stem Cells
Bone Morphogenetic Protein 4
19 Citations (Scopus)
71 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Angiography
Microfluidics
Tomography
Blood Vessels
Thrombosis
5 Citations (Scopus)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanocapsules
Thrombosis
Platelet Aggregation Inhibitors
Bleeding Time
Phosphatidylcholines
40 Citations (Scopus)
43 Downloads (Pure)

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L., 2017, In : Biochemical and biophysical research communications. 482, 2, p. 323-328 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bioassay
Lab-On-A-Chip Devices
Biological Assay
Molecules
Microfluidics
51 Citations (Scopus)
29 Downloads (Pure)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L., 15 Mar 2017, In : Development (Cambridge). 144, 6, p. 1008-1017 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Cardiac Myocytes
Endothelial Cells
Endothelium
Induced Pluripotent Stem Cells
2016
18 Citations (Scopus)
34 Downloads (Pure)

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors

den Hartogh, S. C., Wolstencroft, K., Mummery, C. L. & Passier, R., 19 Jan 2016, In : Scientific reports. 6, 19386.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mesoderm
Gene Expression
Pluripotent Stem Cells
Neoplastic Stem Cells
Gene Regulatory Networks
34 Citations (Scopus)
29 Downloads (Pure)

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Platelets
Point-of-Care Systems
Microfluidics
Endothelium
25 Citations (Scopus)
78 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Microfluidics
Membranes
92 Citations (Scopus)
39 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pericytes
blood-brain barrier
astrocytes
Blood-Brain Barrier
Astrocytes
9 Citations (Scopus)
9 Downloads (Pure)

Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity

den Hartogh, S. C. & Passier, P. C. J. J., 23 Nov 2016, In : Stem cells. 34, 1, p. 13-26

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)
64 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Blood-Brain Barrier
Technology
Time and Motion Studies
Brain
Biomedical Technology Assessment
Health
Technology
Pharmaceutical Preparations
Decision Support Techniques
29 Citations (Scopus)
35 Downloads (Pure)

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K-L. & Sinnecker, D., 2016, In : European heart journal. 38, 4, p. 292–301

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Drug Design
Cardiac Myocytes
Action Potentials
Romano-Ward Syndrome
16 Citations (Scopus)
4 Downloads (Pure)

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., Kutalik, Z. & 9 othersde Vries, A. A. F., Rivard, L., Wilde, A. A. M., Talajic, M., Verkerk, A. O., Al-Gazali, L., Rioux, J. D., Bhuiyan, Z. A. & Passier, R., 1 Dec 2016, In : EMBO molecular medicine. 8, 12, p. 1390-1408 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Cardiac Arrhythmias
Cardiac Myocytes
Genes
Flecainide
2015
9 Citations (Scopus)

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure

Kosmidis, G., Bellin, M., Ribeiro, M. C., Van Meer, B., Ward-Van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S., 27 Nov 2015, In : Biochemical and biophysical research communications. 467, 4, p. 998-1005 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stem cells
Cardiac Myocytes
Dexamethasone
Glucocorticoids
Calcium