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2020

Development of double porous poly (ε - caprolactone)/chitosan polymer as tissue engineering scaffold

Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P., 1 Feb 2020, In : Materials Science and Engineering C. 107, 110257.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2019

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

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7 Citations (Scopus)
355 Downloads (Pure)

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

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1 Citation (Scopus)
24 Downloads (Pure)

Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood

Albers, H. J., Passier, R., van den Berg, A. & van der Meer, A. D., 14 Nov 2019, In : Micromachines. 10, 11, 781.

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1 Citation (Scopus)
13 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

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1 Citation (Scopus)
26 Downloads (Pure)

Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications

de Pinho, A. R. G., Odila, I., Leferink, A., van Blitterswijk, C., Camarero-Espinosa, S. & Moroni, L., 25 Sep 2019, In : Frontiers in bioengineering and biotechnology. 7, SEP, 231.

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1 Citation (Scopus)
11 Downloads (Pure)

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

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12 Citations (Scopus)
43 Downloads (Pure)

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

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17 Citations (Scopus)
21 Downloads (Pure)

Scalable microphysiological system to model three-dimensional blood vessels

de Graf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., Mummery, C. L. & Orlova, V. V., 21 Jun 2019, In : APL Bioengineering. 3, 2, 026105.

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Shape-defined solid micro-objects from poly(D,L-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering

Leferink, A. M., Tibbe, M. P., Bossink, E. G. B. M., de Heus, L. E., van Vossen, H., van den Berg, A., Moroni, L. & Truckenmüller, R. K., Sep 2019, In : Materials Today Bio. 4, 100025.

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1 Citation (Scopus)
18 Downloads (Pure)

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

van Meer, B. J., Krotenberg, A., Sala, L., Davis, R. P., Eschenhagen, T., Denning, C., Tertoolen, L. G. J. & Mummery, C. L., 20 Sep 2019, In : Nature communications. 10, 1, 9 p., 4325.

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3 Citations (Scopus)
13 Downloads (Pure)

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance

Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P., Dec 2019, In : Tissue Engineering - Part A. 25, 23-24, p. 1635-1645 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems

Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., 9 Jul 2018, In : Alternatives to Animal Experimentation. 35, 3, p. 353-378 26 p.

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12 Citations (Scopus)
46 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

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13 Citations (Scopus)
93 Downloads (Pure)

Evolution of the Proximal Sealing Rings of the Anaconda Stent-Graft After Endovascular Aneurysm Repair

Koenrades, M. A., Klein, A., Leferink, A. M., Slump, C. H. & Geelkerken, R. H., 1 Aug 2018, In : Journal of Endovascular Therapy. 25, 4, p. 480-491 12 p.

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5 Citations (Scopus)
77 Downloads (Pure)

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

Tertoolen, L. G. J., Braam, S. R., van Meer, B. J., Passier, R. & Mummery, C. L., 18 Mar 2018, In : Biochemical and biophysical research communications. 497, 4, p. 1135-1141 7 p.

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15 Citations (Scopus)
64 Downloads (Pure)

Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes

Le-The, H., Tibbe, M., Loessberg-Zahl, J., Palma Do Carmo, M., van der Helm, M., Bomer, J., Van Den Berg, A., Leferink, A., Segerink, L. & Eijkel, J., 28 Apr 2018, In : Nanoscale. 10, 16, p. 7711-7718 8 p.

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12 Citations (Scopus)
99 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

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3 Citations (Scopus)
95 Downloads (Pure)

Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., Mosqueira, D. & 7 others, Orlova, V. V., Passier, R., Catarino Ribeiro, M., Saleem, U., Smith, G. L., Burton, F. L. & Mummery, C. L., 2 Feb 2018, In : Circulation research. 122, 3, p. e5-e16

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27 Citations (Scopus)
56 Downloads (Pure)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

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50 Citations (Scopus)
22 Downloads (Pure)
2017

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1765-1779 15 p.

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12 Citations (Scopus)
40 Downloads (Pure)

Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery

Gümüscü, B., Albers, H. J., Van Den Berg, A., Eijkel, J. C. T. & Van Der Meer, A. D., 1 Dec 2017, In : Scientific reports. 7, 3381.

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7 Citations (Scopus)
55 Downloads (Pure)

Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M., 12 May 2017, In : Journal of visualized experiments. 2017, 123, e55587.

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7 Citations (Scopus)
128 Downloads (Pure)
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6 Citations (Scopus)
88 Downloads (Pure)

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1754-1764 11 p.

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13 Citations (Scopus)
76 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

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27 Citations (Scopus)
91 Downloads (Pure)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L., 2017, In : Biochemical and biophysical research communications. 482, 2, p. 323-328 6 p.

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54 Citations (Scopus)
60 Downloads (Pure)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L., 15 Mar 2017, In : Development (Cambridge). 144, 6, p. 1008-1017 10 p.

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63 Citations (Scopus)
40 Downloads (Pure)
2016

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors

den Hartogh, S. C., Wolstencroft, K., Mummery, C. L. & Passier, R., 19 Jan 2016, In : Scientific reports. 6, 19386.

Research output: Contribution to journalArticleAcademicpeer-review

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21 Citations (Scopus)
45 Downloads (Pure)

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

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47 Citations (Scopus)
44 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

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34 Citations (Scopus)
277 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

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119 Citations (Scopus)
51 Downloads (Pure)

Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity

den Hartogh, S. C. & Passier, P. C. J. J., 23 Nov 2016, In : Stem cells. 34, 1, p. 13-26

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
11 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

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93 Citations (Scopus)
113 Downloads (Pure)

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K-L. & Sinnecker, D., 2016, In : European heart journal. 38, 4, p. 292–301

Research output: Contribution to journalArticleAcademicpeer-review

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34 Citations (Scopus)
50 Downloads (Pure)

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., Kutalik, Z. & 9 others, de Vries, A. A. F., Rivard, L., Wilde, A. A. M., Talajic, M., Verkerk, A. O., Al-Gazali, L., Rioux, J. D., Bhuiyan, Z. A. & Passier, R., 1 Dec 2016, In : EMBO molecular medicine. 8, 12, p. 1390-1408 19 p.

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28 Citations (Scopus)
16 Downloads (Pure)
2015

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure

Kosmidis, G., Bellin, M., Ribeiro, M. C., van Meer, B., Ward-van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S., 27 Nov 2015, In : Biochemical and biophysical research communications. 467, 4, p. 998-1005 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)