• 1733 Citations
  • 17 h-Index
20082020

Research output per year

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Research Output

2020

Development of double porous poly (ε - caprolactone)/chitosan polymer as tissue engineering scaffold

Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P., 1 Feb 2020, In : Materials Science and Engineering C. 107, 110257.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2019

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
12 Citations (Scopus)
427 Downloads (Pure)

A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells

Komen, J., Westerbeek, E. Y., van der Meer, A. & van den Berg, A., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood

Albers, H. J., Passier, R., van den Berg, A. & van der Meer, A. D., 14 Nov 2019, In : Micromachines. 10, 11, 781.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
21 Downloads (Pure)

Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion

Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T., 31 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019. Basel, Switzerland: Chemical and Biological Microssytems Society, p. 1530-1531

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
32 Downloads (Pure)

Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function

Zakharova, M., van der Helm, M., Palma Do Carmo, M., Le The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L., 2019.

Research output: Contribution to conferencePoster

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)
57 Downloads (Pure)

Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis

Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A. & Barrile, R., 1 Oct 2019, In : Current Opinion in Toxicology. 17, p. 1-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
23 Citations (Scopus)
27 Downloads (Pure)

Scalable microphysiological system to model three-dimensional blood vessels

de Graf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., Mummery, C. L. & Orlova, V. V., 21 Jun 2019, In : APL Bioengineering. 3, 2, 026105.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
12 Downloads (Pure)

Standardized, modular microfluidic building blocks for automated cell culturing systems

Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A. & Odijk, M., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Diettrich, P., Delamarche, E. & Hierlemann, A. (eds.). 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society, p. 86-87 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

5 Downloads (Pure)

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance

Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P., Dec 2019, In : Tissue Engineering - Part A. 25, 23-24, p. 1635-1645 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R. & Sarro, P. M., 24 Apr 2018, 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. IEEE, Vol. 2018-January. p. 318-321 4 p. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
58 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14 Citations (Scopus)
132 Downloads (Pure)

Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices

Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A. & Eijkel, J. C. T., 11 Nov 2018, MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, G-B. & F-G. T. (eds.). The Chemical and Biological Microsystems Society, p. 2239-2241 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
11 Downloads (Pure)

Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices

Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., Orlova, V. V. & van der Meer, A. D., 11 Nov 2018, MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Tseng, F-G. & Lee, G-B. (eds.). The Chemical and Biological Microsystems Society, p. 2392-2393

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
9 Downloads (Pure)

Membranes for Organs-on-Chips

Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D. & Segerink, L., 2018, Biomedical Membranes and (Bio)Artificial Organs. Stamatialis, D. (ed.). World Scientific, p. 295-321

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
4 Citations (Scopus)
127 Downloads (Pure)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
61 Citations (Scopus)
36 Downloads (Pure)

Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips

Vollertsen, A. R., Dekker, S., Wesselink, B. A. M., Haverkate, R., Bomer, J. G., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., van der Meer, A., Passier, R., van den Berg, A. & Odijk, M., 11 Nov 2018, MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Tseng, F-G. & Lee, G-B. (eds.). The Chemical and Biological Microsystems Society, p. 2199-2201 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
74 Downloads (Pure)
2017

A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array

Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J. & van der Meer, A. D., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 1013 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
15 Downloads (Pure)

A multiplexed organ-on-chip device with individually addressable channels

Palma Do Carmo, M., van der Helm, M. W., van der Meer, A., van den Berg, A., Eijkel, J. C. T. & Segerink, L., May 2017.

Research output: Contribution to conferencePoster

Chipholder-integrated 3d-printed pneumatic logic controllers for microfluidic chips

Loessberg-Zahl, J., Vollenbroek, J., van der Meer, A., Eijkel, J. & van den Berg, A., 22 Oct 2017, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 645 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS(; vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
7 Downloads (Pure)

Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery

Gümüscü, B., Albers, H. J., Van Den Berg, A., Eijkel, J. C. T. & Van Der Meer, A. D., 1 Dec 2017, In : Scientific reports. 7, 3381.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
10 Citations (Scopus)
62 Downloads (Pure)

Configurable gel geometry via flow patterning for angiogenisis assays

Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J. & van den Berg, A., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & D. D. (eds.). The Chemical and Biological Microsystems Society, p. 1074- 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
3 Downloads (Pure)

Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip

van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., van der Meer, A., Eijkel, J., Ingber, D. E., van den Berg, A. & Segerink, L., 24 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). Chemical and Biological Microstystems Society, p. 1114-1115 2 p. (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); vol. 2017).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
23 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
101 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
32 Citations (Scopus)
99 Downloads (Pure)

Organs-on-chips for vascular function

van der Meer, A., 20 Oct 2017, In : Toxicology Letters. 280, 1, p. S29 1 p.

Research output: Contribution to journalSpecial issueAcademicpeer-review

7 Citations (Scopus)
1 Downloads (Pure)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
2016

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
49 Citations (Scopus)
51 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
36 Citations (Scopus)
398 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
134 Citations (Scopus)
58 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
100 Citations (Scopus)
188 Downloads (Pure)
2015

Blood-brain barrier (BBB): an overview of the research of the blood-brain barrier using microfluidic devices

van der Meer, A. D., Wolbers, F. & Vermes, I., 2015, Microfluidics for medical applications. van den Berg, A., Segerink, L. & Segerink, L. I. (eds.). Cambridge: Royal Society of Chemistry, p. 40-53 14 p. (RSC Nanoscience & Nanotechnology; no. 36).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Engineered in vitro disease models

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., Musah, S., Torisawa, Y. S., Van Der Meer, A. D., Villenave, R., Yadid, M., Parker, K. K. & Ingber, D. E., 1 Jan 2015, In : Annual Review of Pathology: Mechanisms of Disease. 10, p. 195-262 68 p.

Research output: Contribution to journalArticleAcademicpeer-review

242 Citations (Scopus)

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., Frimat, J-P., Hamilton, G. A., Ingber, D. E. & van den Berg, A., 2015, In : Lab on a chip. 15, 3, p. 745-752 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

61 Citations (Scopus)
1 Downloads (Pure)

Studying the blood-brain barrier on a microfluidic chip

McKim, J. M. (ed.), van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2015.

Research output: Contribution to conferencePaper

Studying the blood-brain barrier on a microfluidic chip

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., Dec 2015, p. 313-314. 2 p.

Research output: Contribution to conferenceAbstract

File
51 Downloads (Pure)
2013

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

Westein, E., van der Meer, A. D., Kuijpers, M. J. E., Frimat, J-P., van den Berg, A. & Heemskerk, J. W. M., 22 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1357-1362 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
135 Citations (Scopus)
44 Downloads (Pure)

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. M., Weksler, B. B., Romero, A., Couraud, P. O., Vermes, I., van der Meer, A. D. & van den Berg, A., Feb 2013, In : Biomedical microdevices. 15, 1, p. 145-150 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

251 Citations (Scopus)
1 Downloads (Pure)

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

van der Meer, A. D., Orlova, V. V., tem Dijke, P., van den Berg, A. & Mummery, C. L., Aug 2013, In : Lab on a chip. 13, 18, p. 3562-3568 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

94 Citations (Scopus)
2012

Organs-on-chips: breaking the in vitro impasse

van der Meer, A. D. & van den Berg, A., 7 Feb 2012, In : Integrative biology. 4, 5, p. 461-470 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

175 Citations (Scopus)
3 Downloads (Pure)
2010

A microfluidic wound-healing assay for quantifying endothelial cell migration

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Feb 2010, In : American journal of physiology : Heart and circulatory physiology. 298, 2, p. H719-H725

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay

van der Meer, A. D., Poot, A. A., Feijen, J. & Vermes, I., 2010, In : Biomicrofluidics. 4, 1, p. 11103-

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)
1 Downloads (Pure)

Flow Cytometric Analysis of the Uptake of Low-Density Lipoprotein by Endothelial Cells in Microfluidic Channels

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Oct 2010, In : Cytometry. Part A. 77, 10, p. 971-975 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)