• 1494 Citations
  • 16 h-Index
20082020
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Research Output 2008 2020

Abstract
38 Downloads (Pure)

Studying the blood-brain barrier on a microfluidic chip

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., Dec 2015, p. 313-314. 2 p.

Research output: Contribution to conferenceAbstract

File
Article
4 Citations (Scopus)
322 Downloads (Pure)

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Blood Vessels
Technology
Microfluidics
Pharmaceutical Preparations
92 Citations (Scopus)

A microfluidic wound-healing assay for quantifying endothelial cell migration

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Feb 2010, In : American journal of physiology : Heart and circulatory physiology. 298, 2, p. H719-H725

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)
1 Downloads (Pure)

Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay

van der Meer, A. D., Poot, A. A., Feijen, J. & Vermes, I., 2010, In : Biomicrofluidics. 4, 1, p. 11103-

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial cells
Microfluidics
shear stress
Actins
Shear stress
41 Citations (Scopus)
37 Downloads (Pure)

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Platelets
Point-of-Care Systems
Microfluidics
Endothelium
118 Citations (Scopus)
35 Downloads (Pure)

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

Westein, E., van der Meer, A. D., Kuijpers, M. J. E., Frimat, J-P., van den Berg, A. & Heemskerk, J. W. M., 22 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1357-1362 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
von Willebrand Factor
Thrombosis
Platelet Aggregation
Pathologic Constriction
Microfluidics
7 Downloads (Pure)
Open Access
File
Platelets
Microfluidics
Blood
Agglomeration
Image analysis
10 Citations (Scopus)
61 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
organs
chips
Tissue
Cells
Equipment Design
229 Citations (Scopus)
1 Downloads (Pure)

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. M., Weksler, B. B., Romero, A., Couraud, P. O., Vermes, I., van der Meer, A. D. & van den Berg, A., Feb 2013, In : Biomedical microdevices. 15, 1, p. 145-150 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
50 Downloads (Pure)
Open Access
File
Caco-2 Cells
Microfluidics
Hydrogel
Cell Culture Techniques
Perfusion

Development of double porous poly (ε - caprolactone)/chitosan polymer as tissue engineering scaffold

Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P., 14 Oct 2019, In : Materials Science and Engineering C. 107, 110257.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Scaffolds
tissue engineering
Chitosan
Scaffolds (biology)
Tissue engineering
30 Citations (Scopus)
188 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Microfluidics
Membranes
106 Citations (Scopus)
48 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pericytes
blood-brain barrier
astrocytes
Blood-Brain Barrier
Astrocytes
209 Citations (Scopus)

Engineered in vitro disease models

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., Musah, S., Torisawa, Y. S., Van Der Meer, A. D., Villenave, R., Yadid, M., Parker, K. K. & Ingber, D. E., 1 Jan 2015, In : Annual Review of Pathology: Mechanisms of Disease. 10, p. 195-262 68 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood Vessels
Microtechnology
Animal Disease Models
Musculoskeletal System
Pluripotent Stem Cells
6 Citations (Scopus)
74 Downloads (Pure)
Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Fabrication
Equipment and Supplies
9 Citations (Scopus)

Flow Cytometric Analysis of the Uptake of Low-Density Lipoprotein by Endothelial Cells in Microfluidic Channels

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Oct 2010, In : Cytometry. Part A. 77, 10, p. 971-975 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
24 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Hydrogel
Hydrogels
Gels
Technology
28 Downloads (Pure)

Lowering caveolin-1 expression in human vascular cells inhibits signal transduction in response to shear stress

van der Meer, A. D., Kamphuis, M., Poot, A. A., Feijen, J. & Vermes, I., 2009, In : Journal of cell biology. 532432, p. - 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
50 Citations (Scopus)
1 Downloads (Pure)

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., Frimat, J-P., Hamilton, G. A., Ingber, D. E. & van den Berg, A., 2015, In : Lab on a chip. 15, 3, p. 745-752 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
69 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Cells
Fabrication
Endothelial cells
Physiology
87 Citations (Scopus)
90 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Blood-Brain Barrier
Technology
Time and Motion Studies
Brain
60 Citations (Scopus)
40 Downloads (Pure)

Microfluidic technology in vascular research

van der Meer, A. D., Poot, A. A., Duits, M. H. G., Feijen, J. & Vermes, I., 2009, In : Journal of biomedicine and biotechnology. ID, 823148, p. - 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
24 Citations (Scopus)
86 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Angiography
Microfluidics
Tomography
Blood Vessels
Thrombosis
8 Citations (Scopus)
35 Downloads (Pure)

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dielectric Spectroscopy
Electric Impedance
Acoustic impedance
Cells
Spectroscopy
17 Citations (Scopus)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD40 Ligand
Thrombosis
Monoclonal Antibodies
Thrombin
Platelet Activation
170 Citations (Scopus)
3 Downloads (Pure)

Organs-on-chips: breaking the in vitro impasse

van der Meer, A. D. & van den Berg, A., 7 Feb 2012, In : Integrative biology. 4, 5, p. 461-470 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biomedical Technology Assessment
Health
Technology
Pharmaceutical Preparations
Decision Support Techniques
12 Citations (Scopus)
17 Downloads (Pure)

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Precision Medicine
Medicine
Physiology
Testing
Cell culture
44 Citations (Scopus)
18 Downloads (Pure)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Thrombosis
Lung
Microfluidics
Endothelium
Therapeutics
7 Citations (Scopus)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanocapsules
Thrombosis
Platelet Aggregation Inhibitors
Bleeding Time
Phosphatidylcholines
4 Citations (Scopus)

Shear stress induces a transient and VEGFR-2-dependent decrease in the motion of injected particles in endothelial cells

van der Meer, A. D., Li, Y., Duits, M. H. G., Poot, A. A., Feijen, J. & Vermes, I., 2010, In : Biorheology. 47, 3-4, p. 179-192 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vascular Endothelial Growth Factor Receptor-2
Endothelial Cells
Cytoskeleton
Blood Vessels
90 Citations (Scopus)

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

van der Meer, A. D., Orlova, V. V., tem Dijke, P., van den Berg, A. & Mummery, C. L., Aug 2013, In : Lab on a chip. 13, 18, p. 3562-3568 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance

Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P., Dec 2019, In : Tissue Engineering - Part A. 25, 23-24, p. 1635-1645 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydraulics
Membranes
Tissue Engineering
Tissue engineering
Chitosan
Chapter

Blood-brain barrier (BBB): an overview of the research of the blood-brain barrier using microfluidic devices

van der Meer, A. D., Wolbers, F. & Vermes, I., 2015, Microfluidics for medical applications. van den Berg, A., Segerink, L. & Segerink, L. I. (eds.). Cambridge: Royal Society of Chemistry, p. 40-53 14 p. (RSC Nanoscience & Nanotechnology; no. 36).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Membranes for Organs-on-Chips

Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D. & Segerink, L., 2018, Biomedical Membranes and (Bio)Artificial Organs. Stamatialis, D. (ed.). World Scientific, p. 295-321

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Conference contribution

A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array

Gümüscü Sefünc, B., Albers, H. J., van den Berg, A., Eijkel, J. C. T. & van der Meer, A., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 1013 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Cellular Microenvironment
Hydrogel
Caco-2 Cells
Coculture Techniques
Epithelial Cells

A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells

Komen, J., Westerbeek, E. Y., van der Meer, A. & van den Berg, A., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

12 Downloads (Pure)

A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R. & Sarro, P. M., 24 Apr 2018, 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. IEEE, Vol. 2018-January. p. 318-321 4 p. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Polydimethylsiloxane
organs
assembly
chips
Throughput

Chipholder-integrated 3d-printed pneumatic logic controllers for microfluidic chips

Loessberg-Zahl, J. T., Vollenbroek, J. C., van der Meer, A., Eijkel, J. C. T. & van den Berg, A., 22 Oct 2017, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & DeVoe, D. (eds.). The Chemical and Biological Microsystems Society, p. 645 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Microfluidics
Pneumatics
Controllers
Multilayers
Automation

Configurable gel geometry via flow patterning for angiogenisis assays

Loessberg-Zahl, J. T., Makkinga, D., van der Meer, A., Eijkel, J. C. T. & van den Berg, A., 22 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, A. & D. D. (eds.). The Chemical and Biological Microsystems Society, p. 1074- 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Assays
Gels
Oncology
Geometry
Proteins
11 Downloads (Pure)

Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip

van der Helm, M. W., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L., 24 Oct 2017, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. Savannah: Chemical and Biological Microstystems Society, p. 1114-1115 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

electrical resistance
alternating current
chips
electrodes
simulation

Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices

Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A. & Eijkel, J. C. T., 11 Nov 2018, MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Lee, G-B. & F-G. T. (eds.). The Chemical and Biological Microsystems Society, p. 2239-2241 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

solute
gel
collagen
laminar flow
dye
1 Downloads (Pure)

Standardized, modular microfluidic building blocks for automated cell culturing systems

Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A. & Odijk, M., 28 Oct 2019, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Diettrich, P., Delamarche, E. & Hierlemann, A. (eds.). 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society, p. 86-87 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Microfluidics
Fluidics
Encapsulation
Assays
Screening
62 Downloads (Pure)

Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips

Vollertsen, A. R., Dekker, S., Wesselink, B. A. M., Haverkate, R., Bomer, J. G., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., van der Meer, A., Passier, R., van den Berg, A. & Odijk, M., 11 Nov 2018, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences: MicroTAS. p. 2199-2201 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Microfluidics
Lab-On-A-Chip Devices
Human Umbilical Vein Endothelial Cells
Drug Industry
Cell Culture Techniques

The role of caveolin-1 in the endothelial cell response to shear stress

Van Der Meer, A., Kamphuis, M., Poot, A., Vermes, I. & Feijen, J., 1 Dec 2008, 8th World Biomaterials Congress 2008. Vol. 2. p. 1031 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Paper

A microfluidic device for monitoring siRNA delivery under fluid flow

van der Meer, A. D., Sam, A. P. (ed.), Kamphuis, M., Poot, A. A., Feijen, J. & Vermes, I., 2 Apr 2008, p. 181-184.

Research output: Contribution to conferencePaper

A microfluidic device for monitoring siRNA delivery under fluid now

van der Meer, A. D., Feijen, J. (ed.), Kamphuis, M., Hennink, W. E. (ed.), Poot, A. A., Sam, A. P. (ed.), Feijen, J. & Vermes, I., 2 Apr 2008, p. e42-e44.

Research output: Contribution to conferencePaper

Studying the blood-brain barrier on a microfluidic chip

McKim, J. M. (ed.), van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2015.

Research output: Contribution to conferencePaper

PhD Thesis - Research UT, graduation UT
39 Downloads (Pure)

Microfluidic technology in vascular research: the endothelial response to shear stress

van der Meer, A. D., 10 Mar 2010, Enschede: Universiteit Twente. 107 p.

Research output: ThesisPhD Thesis - Research UT, graduation UT

Open Access
File
Microfluidics
Blood Vessels
Technology
LDL Lipoproteins
Research