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20082019
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Research Output 2008 2019

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Article
2019
1 Citation (Scopus)
11 Downloads (Pure)

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 206-213 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Hydrogel
Hydrogels
Gels
Technology
1 Citation (Scopus)
9 Downloads (Pure)

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I., 29 Jan 2019, In : Lab on a chip. 19, 3, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Dielectric Spectroscopy
Electric Impedance
Acoustic impedance
Cells
Spectroscopy
4 Citations (Scopus)
3 Downloads (Pure)

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Precision Medicine
Medicine
Physiology
Testing
Cell culture
2018
3 Citations (Scopus)
253 Downloads (Pure)
Open Access
File
Induced Pluripotent Stem Cells
Blood Vessels
Technology
Microfluidics
Pharmaceutical Preparations
3 Citations (Scopus)
33 Downloads (Pure)

Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D., 1 Jul 2018, In : Biomicrofluidics. 12, 4, 042218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
organs
chips
Tissue
Cells
Equipment Design
24 Downloads (Pure)

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M., 10 Sep 2018, In : Scientific reports. 8, 1, 13524.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Membranes
Cells
Fabrication
Endothelial cells
Physiology
10 Citations (Scopus)

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A., Dec 2018, In : Clinical pharmacology & therapeutics. 104, 6, p. 1240-1248 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

CD40 Ligand
Thrombosis
Monoclonal Antibodies
Thrombin
Platelet Activation
31 Citations (Scopus)
4 Downloads (Pure)

Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E., 1 Feb 2018, In : Clinical pharmacology & therapeutics. 103, 2, p. 332-340 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Thrombosis
Lung
Microfluidics
Endothelium
Therapeutics
2017
4 Citations (Scopus)
37 Downloads (Pure)
Open Access
File
Caco-2 Cells
Microfluidics
Hydrogel
Cell Culture Techniques
Perfusion
5 Citations (Scopus)
52 Downloads (Pure)
Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Fabrication
Equipment and Supplies
18 Citations (Scopus)
71 Downloads (Pure)

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D., 2017, In : Lab on a chip. 17, 16, p. 2785-2792 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Angiography
Microfluidics
Tomography
Blood Vessels
Thrombosis
5 Citations (Scopus)

Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation

Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E., 1 May 2017, In : Journal of thrombosis and haemostasis. 15, 5, p. 972-982 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nanocapsules
Thrombosis
Platelet Aggregation Inhibitors
Bleeding Time
Phosphatidylcholines
2016
33 Citations (Scopus)
27 Downloads (Pure)

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Jain, A., van der Meer, A. D., Papa, A-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E., 2016, In : Biomedical microdevices. 18, 73, p. 73- 7 p., 73.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Lab-On-A-Chip Devices
Platelets
Point-of-Care Systems
Microfluidics
Endothelium
25 Citations (Scopus)
62 Downloads (Pure)

Direct quantification of transendothelial electrical resistance in organs-on-chips

van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Biosensors and bioelectronics. 85, p. 924-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Acoustic impedance
Electric Impedance
Electrodes
Microfluidics
Membranes
91 Citations (Scopus)
38 Downloads (Pure)

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T-E., Sleeboom, J. J. F. & Ingber, D. E., 2016, In : PLoS ONE. 11, 3, p. - e0150360.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pericytes
blood-brain barrier
astrocytes
Blood-Brain Barrier
Astrocytes
76 Citations (Scopus)
63 Downloads (Pure)

Microfluidic organ-on-chip technology for blood-brain barrier research

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2016, In : Tissue barriers. 4, 1, p. e1142493- e1142493.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Blood-Brain Barrier
Technology
Time and Motion Studies
Brain
Biomedical Technology Assessment
Health
Technology
Pharmaceutical Preparations
Decision Support Techniques
2015
190 Citations (Scopus)

Engineered in vitro disease models

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., Musah, S., Torisawa, Y. S., Van Der Meer, A. D., Villenave, R., Yadid, M., Parker, K. K. & Ingber, D. E., 1 Jan 2015, In : Annual Review of Pathology: Mechanisms of Disease. 10, p. 195-262 68 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood Vessels
Microtechnology
Animal Disease Models
Musculoskeletal System
Pluripotent Stem Cells
44 Citations (Scopus)
1 Downloads (Pure)

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., Frimat, J-P., Hamilton, G. A., Ingber, D. E. & van den Berg, A., 2015, In : Lab on a chip. 15, 3, p. 745-752 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
112 Citations (Scopus)
24 Downloads (Pure)

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

Westein, E., van der Meer, A. D., Kuijpers, M. J. E., Frimat, J-P., van den Berg, A. & Heemskerk, J. W. M., 22 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1357-1362 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
von Willebrand Factor
Thrombosis
Platelet Aggregation
Pathologic Constriction
Microfluidics
215 Citations (Scopus)
1 Downloads (Pure)

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

Griep, L. M., Wolbers, F., de Wagenaar, B., ter Braak, P. M., Weksler, B. B., Romero, A., Couraud, P. O., Vermes, I., van der Meer, A. D. & van den Berg, A., Feb 2013, In : Biomedical microdevices. 15, 1, p. 145-150 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

89 Citations (Scopus)

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

van der Meer, A. D., Orlova, V. V., tem Dijke, P., van den Berg, A. & Mummery, C. L., Aug 2013, In : Lab on a chip. 13, 18, p. 3562-3568 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
165 Citations (Scopus)
3 Downloads (Pure)

Organs-on-chips: breaking the in vitro impasse

van der Meer, A. D. & van den Berg, A., 7 Feb 2012, In : Integrative biology. 4, 5, p. 461-470 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010
89 Citations (Scopus)

A microfluidic wound-healing assay for quantifying endothelial cell migration

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Feb 2010, In : American journal of physiology : Heart and circulatory physiology. 298, 2, p. H719-H725

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay

van der Meer, A. D., Poot, A. A., Feijen, J. & Vermes, I., 2010, In : Biomicrofluidics. 4, 1, p. 11103-

Research output: Contribution to journalArticleAcademicpeer-review

Microfluidics
Endothelial cells
Actin Cytoskeleton
shear stress
Actins
9 Citations (Scopus)

Flow Cytometric Analysis of the Uptake of Low-Density Lipoprotein by Endothelial Cells in Microfluidic Channels

van der Meer, A. D., Vermeul, K., Poot, A. A., Feijen, J. & Vermes, I., Oct 2010, In : Cytometry. Part A. 77, 10, p. 971-975 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Shear stress induces a transient and VEGFR-2-dependent decrease in the motion of injected particles in endothelial cells

van der Meer, A. D., Li, Y., Duits, M. H. G., Poot, A. A., Feijen, J. & Vermes, I., 2010, In : Biorheology. 47, 3-4, p. 179-192 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vascular Endothelial Growth Factor Receptor-2
Endothelial Cells
Cytoskeleton
Blood Vessels
2009
20 Downloads (Pure)

Lowering caveolin-1 expression in human vascular cells inhibits signal transduction in response to shear stress

van der Meer, A. D., Kamphuis, M., Poot, A. A., Feijen, J. & Vermes, I., 2009, In : Journal of cell biology. 532432, p. - 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
59 Citations (Scopus)
33 Downloads (Pure)

Microfluidic technology in vascular research

van der Meer, A. D., Poot, A. A., Duits, M. H. G., Feijen, J. & Vermes, I., 2009, In : Journal of biomedicine and biotechnology. ID, 823148, p. - 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

File