Christian Blum

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  • 1165 Citations
  • 17 h-Index
20022019
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Research Output 2002 2019

2019
2 Citations (Scopus)
14 Downloads (Pure)

Cooperation of Helix Insertion and Lateral Pressure to Remodel Membranes

Fakhree, M. A. A., Engelbertink, S. A. J., Van Leijenhorst-Groener, K. A., Blum, C. & Claessens, M. M. A. E., 11 Mar 2019, In : Biomacromolecules. 20, 3, p. 1217-1223 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Proteins
Membranes
Synucleins
Compaction
Fusion reactions
12 Downloads (Pure)

Photonic emitter manipulation to sample nanoscale topography

Mateos, N., Molenaar, R., Claessens, M. M. A. E. & Blum, C., 15 Apr 2019, In : Optics express. 27, 8, p. 11698-11708 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
manipulators
topography
emitters
photonics
probes
5 Downloads (Pure)

Shaping membranes with disordered proteins

Fakhree, M. A. A., Blum, C. & Claessens, M. M. A. E., 30 Nov 2019, In : Archives of biochemistry and biophysics. 677, 108163.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Membranes
Membrane Proteins
Proteins
Intrinsically Disordered Proteins
Eukaryota
2018
6 Citations (Scopus)
45 Downloads (Pure)

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells

Fakhree, M. A. A., Nolten, I. S., Blum, C. & Claessens, M. M. A. E., 15 Mar 2018, In : Journal of physical chemistry letters. 9, 6, p. 1249-1253 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Intrinsically Disordered Proteins
Energy transfer
proteins
Proteins
71 Downloads (Pure)

Functional Insights into Membrane Bound α-Synuclein: Surface Density, Conformation, and Localization inside Cells

Abolghassemi Fakhree, M. A., 7 Nov 2018, Enschede: University of Twente. 160 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

Open Access
File
Synucleins
Membranes
Intrinsically Disordered Proteins
Photobleaching
alpha-Synuclein
3 Citations (Scopus)
35 Downloads (Pure)

Polymorph-specific distribution of binding sites determines thioflavin-T fluorescence intensity in α-synuclein fibrils

Sidhu, A., Vaneyck, J., Blum, C., Segers-Nolten, I. & Subramaniam, V., 3 Jul 2018, In : Amyloid. 25, 3, p. 189-196 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Fluorescence
Binding Sites
Amyloid
thioflavin T
2017
7 Citations (Scopus)
47 Downloads (Pure)

Controlling Protein Surface Orientation by Strategic Placement of Oligo-Histidine Tags

Wasserberg, D., Cabanas-Danés, J., Prangsma, J., O'Mahony, S., Cazade, P. A., Tromp, E., Blum, C., Thompson, D., Huskens, J., Subramaniam, V. & Jonkheijm, P., 26 Sep 2017, In : ACS nano. 11, 9, p. 9068-9083 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
His-His-His-His-His-His
histidine
Histidine
Membrane Proteins
proteins
2016
2 Citations (Scopus)

Monitoring the Switching of Single BSA-ATTO 488 Molecules Covalently End-Attached to a pH-Responsive PAA Brush

Akkilic, N., Molenaar, R., Claessens, M. M. A. E., Blum, C. & de Vos, W. M., 2016, In : Langmuir. 32, 35, p. 8803-8811

Research output: Contribution to journalArticleAcademicpeer-review

brushes
Brushes
Bovine Serum Albumin
albumins
serums
1 Citation (Scopus)
47 Downloads (Pure)

Size-selective analyte detection with a Young Interferometer sensor using multiple wavelenghts

Mulder, H., Blum, C., Subramaniam, V. & Kanger, J. S., 2016, In : Optics express. 24, 8, p. 8594-8619 26 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
interferometers
sensors
beads
proteins
optical measuring instruments
11 Citations (Scopus)
Synucleins
Membranes
R-SNARE Proteins
Proteins
Protein S
56 Downloads (Pure)

The number of α-synuclein proteins per vesicle gives insights into its physiological function

Abolghassemi Fakhree, M. A., Zijlstra, N., Raiss, C. C., Siero, R., Grabmayr, H., Bausch, A. R., Blum, C. & Claessens, M. M. A. E., 2016, In : Scientific reports. 6, 30658, 30658.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Membranes
Proteins
Protein S
R-SNARE Proteins
2015
6 Citations (Scopus)

Alpha-Synuclein Amyloid Oligomers Act as Multivalent Nanoparticles to Cause Hemifusion in Negatively Charged Vesicles

Stefanovic, A., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 15 Jan 2015, In : Small. 11, 19, p. 2257-2262

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Direct patterning of nanoparticles and biomolecules by liquid nanodispensing

Fabie, L., Agostini, P., Stopel, M. H. W., Blum, C., Lassagne, B., Subramaniam, V. & Ondarcuhua, T., 2015, In : Nanoscale. 7, 10, p. 4497-4504 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Microcantilever based distance control between a probe and a surface

Molenaar, R., Prangsma, J., van der Werf, K., Bennink, M. L., Blum, C. & Subramaniam, V., 2015, In : Review of scientific instruments. 86, 063706, p. - 8 p., 063706.

Research output: Contribution to journalArticleAcademicpeer-review

6 Downloads (Pure)

Nanophotonic measurement of the dark fraction in red fluorescent proteins

Prangsma, J. C., Molenaar, R., Subramaniam, V. & Blum, C., 31 Mar 2015. 1 p.

Research output: Contribution to conferenceAbstractAcademic

Open Access
File
1 Citation (Scopus)

Non-invasive imaging through opaque scattering layers

Bertolotti, J., van Putten, E. G., Blum, C., Lagendijk, A., Vos, W. L. & Mosk, A. P., 7 Feb 2015, Adaptive Optics and Wavefront Control for Biological Systems. Bifano, T. G., Kubby, J. & Gigan, S. (eds.). Bellingham, WA, USA: SPIE, p. 1-7 (Proceedings of SPIE; vol. 9335).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

blurring
halos
light scattering
scattering

Photonic effects on the fluorescence lifetimes of dyes in thin PVA layers

Prangsma, J. C., Molenaar, R., Subramaniam, V. & Blum, C., 26 Aug 2015, Nanoimaging and Nanospectroscopy III. SPIE, Vol. 9554. 95540G

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Fluorescence Lifetime
Fluorophores
Thin Layer
Dyes
Photonics
2014

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, N., Blum, C. & Claessens, M. M. A. E., 29 Sep 2014, p. -.

Research output: Contribution to conferencePosterOther research output

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, J., Blum, C. & Claessens, M. M. A. E., 22 Sep 2014, p. -.

Research output: Contribution to conferencePosterOther research output

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, J., Blum, C. & Claessens, M. M. A. E., 17 Nov 2014, p. -.

Research output: Contribution to conferencePosterOther research output

13 Citations (Scopus)
7 Downloads (Pure)

Elucidating the Aggregation Number of Dopamine-Induced alpha-Synuclein Oligomeric Assemblies

Zijlstra, N., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 2014, In : Biophysical journal. 106, 2, p. 440-446 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
alpha-Synuclein
Dopamine
Photobleaching
Amyloid
14 Citations (Scopus)

Excitation Spectra and Stokes Shift Measurements of Single Organic Dyes at Room Temperature

Stopel, M. H. W., Blum, C. & Subramaniam, V., 2014, In : Journal of physical chemistry letters. 5, 18, p. 3259-3264 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Multimodal fluorescence imaging spectroscopy

Stopel, M. H. W., Blum, C. & Subramaniam, V., 2014, Fluorescence Spectroscopy and Microscopy: Methods and Protocols. Engelborghs, Y. & Visser, A. J. W. G. (eds.). Humana Press, p. 521-536 16 p. (Methods in Molecular Biology ; vol. 1076).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Multimodal Imaging
Optical Imaging
Fluorescence Spectrometry
37 Downloads (Pure)

Multimodal spectroscopy of single fluorescent nanoprobes: photophysics and characterization

Stopel, M. H. W., 25 Sep 2014, Enschede: Universiteit Twente. 130 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

File
Nanoprobes
Fluorophores
Spectroscopy
Fluorescence microscopy
Fluorescence

Nanophotonic measurement of the dark fraction in red fluorescent proteins

Prangsma, J. C., Molenaar, R., Subramaniam, V. & Blum, C., 21 Jul 2014, European Conference on Lasers and Electro-Optics, CLEO 2015. Optical Society of America

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

49 Downloads (Pure)

Parkinson's disease in the spotlight: unraveling nanoscale α-Synuclein oligomers using ultrasensitive single-molecule spectroscopy

Zijlstra, N., 17 Oct 2014, Enschede: Universiteit Twente. 161 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

File
Synucleins
Oligomers
Spectroscopy
Agglomeration
Molecules
3 Citations (Scopus)

Photosynthesis in a different light: Spectro-microscopy for in vivo characterization of chloroplasts

Peter, S., Zell, M. B., Blum, C., Stuhl, A., Elgass, K., Sackrow, M., Subramaniam, V., Meixner, A. J., Harter, K., Maurino, V. G. & Schleifenbaum, F. E., 30 Jun 2014, In : Frontiers in Plant Science. 5, JUN, 292.

Research output: Contribution to journalArticleAcademicpeer-review

microscopy
chloroplasts
photosynthesis
energy conversion
light quality
31 Citations (Scopus)
63 Downloads (Pure)

Predicting the Loading of Virus-Like Particles with Fluorescent Proteins

Rurup, W. F., Verbij, F., Koay, M. S. T., Blum, C., Subramaniam, V. & Cornelissen, J. J. L. M., 2014, In : Biomacromolecules. 15, 2, p. 558-563 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

File

Single-Molecule Spectroscopy

Schleifenbaum, F., Blum, C., Brecht, M. & Meixner, A. J., 2014, Handbook of Spectroscopy. Gauglitz, G. & Moore, D. S. (eds.). Wiley-VCH Verlag, p. 821-876 56 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2013

Aggregation conditions strongly influence the molecular composition of alpha-synuclein oligomers

Zijlstra, N., Blum, C. & Subramaniam, V., 2013, In : European biophysics journal. 42, Suppl. 1, p. S200-S200

Research output: Contribution to journalMeeting AbstractOther research output

alpha-Synuclein
Photobleaching
Parkinson Disease
Dopamine
Protein Aggregates
5 Citations (Scopus)
12 Downloads (Pure)

Blinking statistics of colloidal quantum dots at different excitation wavelengths

Stopel, M. H. W., Prangsma, J. C., Blum, C. & Subramaniam, V., 14 Oct 2013, In : RSC advances. 3, 38, p. 17440-17445 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Semiconductor quantum dots
Statistics
Wavelength
Imaging techniques
Microscopic examination

Can nanophotonics control the Förster resonance energy transfer efficiency?

Blum, C., Zijlstra, N., Lagendijk, A., Wubs, M., Mosk, A. P., Subramaniam, V. & Vos, W. L., 1 Jan 2013.

Research output: Contribution to conferencePaperAcademicpeer-review

Nanophotonics
Energy transfer
Fluorophores
Bacteria
Lighting

Imaging Through Scattering Media

Bertolotti, J., van Putten, E. G., Blum, C., Lagendijk, A., Vos, W. L. & Mosk, A., 23 Jun 2013, Optics InfoBase Conference Papers 2013. Arlington, VA: Optical Society of America, p. P1-3 104495

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

scattering
autocorrelation
illumination
inversions
detectors

Nanophotonic control of the Foerster resonance energy transfer efficiency

Zijlstra, N., Lagendijk, A., Wubs, M., Mosk, A., Subramaniam, V., Vos, W. L. & Blum, C., 22 Jan 2013, p. -.

Research output: Contribution to conferencePosterOther research output

Noninvasive fluorescence imaging through strongly scattering layers

Bertolotti, J., Putten, E. G., Blum, C., Lagendijk, A., Vos, W. L. & Mosk, A. P., 1 Jan 2013.

Research output: Contribution to conferencePaperAcademicpeer-review

Fluorescence
Scattering
Imaging techniques
Ballistics
Optical tomography

Optical nanoscopy to study protein aggregation: function versus toxicity

Zijlstra, N., Raiss, C. C., Siemerink-Konings, I., Chaudhary, H., Subramaniam, V., Blum, C. & Claessens, M. M. A. E., 16 Sep 2013, p. -.

Research output: Contribution to conferencePosterOther research output

3 Downloads (Pure)

Retrieving the fluorescence quantum yield using a controlled photonic environment

Prangsma, J. C., Meijer, L., Subramaniam, V. & Blum, C., 25 Mar 2013. 1 p.

Research output: Contribution to conferencePosterOther research output

Open Access
File
38 Downloads (Pure)

Shining light on amyloid protein aggregates: Single-molecule photobleaching of sub-stoichiometrically labeled α-synuclein oligomers reveals molecular composition

Zijlstra, N., Segers-Nolten, I., Claessens, M., Blum, C. & Subramaniam, V., 2013, In : Microscopy and analysis (E MEA edition). 2013, 7, p. 24-24 1 p.

Research output: Contribution to journalConference articleAcademicpeer-review

2012

Answer to energy transfer debate could impact areas from photovoltaics to quantum information

Blum, C., 2012

Research output: Non-textual formWeb publication/siteOther research output

Establishing the composition of α-synuclein amyloid oligomers using single-molecule photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, I., Claessens, M. & Subramaniam, V., 1 Oct 2012.

Research output: Contribution to conferencePosterOther research output

Establishing the molecular composition of alpha-synuclein oligomers by sub-stoichiometric labeling and single-molecule photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 17 Jan 2012, p. -.

Research output: Contribution to conferencePosterOther research output

Establishing the molecular composition of alpha-synuclein oligomers by sub-stoichiometric labeling and single-molecule photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 25 Feb 2012, p. -.

Research output: Contribution to conferencePosterOther research output

Molecular composition of sub-stoichiometrically labeled alpha-synuclein oligomers determined by single-molecule photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 1 Oct 2012, p. -.

Research output: Contribution to conferencePosterOther research output

46 Citations (Scopus)

Molecular Composition of Sub-stoichiometrically Labeled alpha-Synuclein Oligomers Determined by Single-Molecule Photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 13 Jul 2012, In : Angewandte Chemie (international edition). 51, 35, p. 8821-8824 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Composition of Sub-stoichiometrically Labeled alpha-Synuclein Oligomers Determined by Single-Molecule Photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 2012, In : Angewandte Chemie. 124, 35, p. 8951-8954 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multi-dimensional blinking statistics of CdSe core-shell quantum dots

Stopel, M. H. W., Blum, C. & Subramaniam, V., 14 Aug 2012, p. -.

Research output: Contribution to conferencePosterOther research output

94 Citations (Scopus)
36 Downloads (Pure)

Nanophotonic control of the Forster resonance energy transfer efficiency

Blum, C., Zijlstra, N., Lagendijk, A., Wubs, M., Mosk, A. P., Subramaniam, V. & Vos, W. L., 2012, In : Physical review letters. 109, 20, 5 p., 203601.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
energy transfer
strands
positioning
deoxyribonucleic acid
dyes
417 Citations (Scopus)

Non-invasive imaging through opaque scattering layers

Bertolotti, J., van Putten, E. G., Blum, C., Lagendijk, A., Vos, W. L. & Mosk, A., 2012, In : Nature. 491, p. 232-234 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Patterning perylenes on surfaces using thiol-ene chemistry

Wasserberg, D., Steentjes, T., Stopel, M. H. W., Huskens, J., Blum, C., Subramaniam, V. & Jonkheijm, P., 2012, In : Journal of materials chemistry. 22, p. 16606-16610 5 p.

Research output: Contribution to journalArticleAcademicpeer-review