C.L. Mummery

prof.dr.

  • 1776 Citations
  • 18 h-Index
20072019
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Research Output 2007 2019

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Article
2019
4 Citations (Scopus)
297 Downloads (Pure)

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A., 1 Feb 2019, In : Advanced drug delivery reviews. 140, p. 68-77 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Blood Vessels
Technology
Microfluidics
Pharmaceutical Preparations
10 Citations (Scopus)
11 Downloads (Pure)

Personalised organs-on-chips: functional testing for precision medicine

Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D., 21 Jan 2019, In : Lab on a chip. 19, 2, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Precision Medicine
Medicine
Physiology
Testing
Cell culture
1 Citation (Scopus)
4 Downloads (Pure)

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

van Meer, B. J., Krotenberg, A., Sala, L., Davis, R. P., Eschenhagen, T., Denning, C., Tertoolen, L. G. J. & Mummery, C. L., 20 Sep 2019, In : Nature communications. 10, 1, 9 p., 4325.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Excitation Contraction Coupling
Cardiac Myocytes
Action Potentials
contraction
2018
1 Citation (Scopus)

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2

Thalgott, J. H., Dos-Santos-Luis, D., Hosman, A. E., Martin, S., Lamandé, N., Bracquart, D., Srun, S., Galaris, G., de Boer, H. C., Tual-Chalot, S., Kroon, S., Arthur, H. M., Cao, Y., Snijder, R. J., Disch, F., Mager, J. J., Rabelink, T. J., Mummery, C. L., Raymond, K. & Lebrin, F., 4 Dec 2018, In : Circulation. 138, 23, p. 2698-2712 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vascular Endothelial Growth Factor Receptor-1
Blood Vessels
Mycoplasma pulmonis
Pathologic Neovascularization
Haploinsufficiency
12 Citations (Scopus)
53 Downloads (Pure)

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

Tertoolen, L. G. J., Braam, S. R., van Meer, B. J., Passier, R. & Mummery, C. L., 18 Mar 2018, In : Biochemical and biophysical research communications. 497, 4, p. 1135-1141 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Toxicity
Screening
18 Citations (Scopus)
27 Downloads (Pure)

Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., Mosqueira, D. & 7 othersOrlova, V. V., Passier, R., Catarino Ribeiro, M., Saleem, U., Smith, G. L., Burton, F. L. & Mummery, C. L., 2 Feb 2018, In : Circulation research. 122, 3, p. e5-e16

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Muscle Contraction
Cardiac Myocytes
Myocardium
Software
Pluripotent Stem Cells
12 Citations (Scopus)
4 Downloads (Pure)

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Anderson, D. J., Kaplan, D. I., Bell, K. M., Koutsis, K., Haynes, J. M., Mills, R. J., Phelan, D. G., Qian, E. L., Leitoguinho, A. R., Arasaratnam, D., Labonne, T., Ng, E. S., Davis, R. P., Casini, S., Passier, R., Hudson, J. E., Porrello, E. R., Costa, M. W., Rafii, A., Curl, C. L. & 9 othersDelbridge, L. M., Harvey, R. P., Oshlack, A., Cheung, M. M., Mummery, C. L., Petrou, S., Elefanty, A. G., Stanley, E. G. & Elliott, D. A., 10 Apr 2018, In : Nature communications. 9, 1, 1373.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stem cells
Gene Regulatory Networks
mutations
genes
Stem cells
2017
8 Citations (Scopus)
34 Downloads (Pure)

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes

Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1765-1779 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Ovalbumin
Stem cells
Cardiac Myocytes
Transcription Factors
Pluripotent Stem Cells
6 Citations (Scopus)
88 Downloads (Pure)

Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs)

Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M., 12 May 2017, In : Journal of visualized experiments. 2017, 123, e55587.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Electrodes
Induced Pluripotent Stem Cells
21 Citations (Scopus)
4 Downloads (Pure)

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, S., Arakawa, T., Fukuda, S., Furuno, M., Hasegawa, A., Hori, F., Ishikawa-Kato, S., Kaida, K., Kaiho, A., Kanamori-Katayama, M., Kawashima, T., Kojima, M., Kubosaki, A., Manabe, R. I., Murata, M., Nagao-Sato, S., Nakazato, K., Ninomiya, N., Nishiyori-Sueki, H., Noma, S. & 158 othersSaijyo, E., Saka, A., Sakai, M., Simon, C., Suzuki, N., Tagami, M., Watanabe, S., Yoshida, S., Arner, P., Axton, R. A., Babina, M., Kenneth Baillie, J., Barnett, T. C., Beckhouse, A. G., Blumenthal, A., Bodega, B., Bonetti, A., Briggs, J., Brombacher, F., Carlisle, A. J., Clevers, H. C., Davis, C. A., Detmar, M., Dohi, T., Edge, B. A. S., Edinger, M., Ehrlund, A., Ekwall, K., Endoh, M., Enomoto, H., Eslami, A., Fagiolini, M., Fairbairn, L., Farach-Carson, M. C., Faulkner, G. J., Ferrai, C., Fisher, M. E., Forrester, L. M., Fujita, R., Furusawa, J. I., Geijtenbeek, T. B., Gingeras, T., Goldowitz, D., Guhl, S., Guler, R., Gustincich, S., Ha, T. J., Hamaguchi, M., Hara, M., Hasegawa, Y., Herlyn, M., Heutink, P., Hitchens, K. J., Hume, D. A., Ikawa, T., Ishizu, Y., Kai, C., Kawamoto, H., Kawamura, Y. I., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L. M., Kitamura, T., Klein, S., Peter Klinken, S., Knox, A. J., Kojima, S., Koseki, H., Koyasu, S., Lee, W., Lennartsson, A., MacKay-Sim, A., Mejhert, N., Mizuno, Y., Morikawa, H., Morimoto, M., Moro, K., Morris, K. J., Motohashi, H., Mummery, C. L., Nakachi, Y., Nakahara, F., Nakamura, T., Nakamura, Y., Nozaki, T., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Okada-Hatakeyama, M., Okazaki, Y., Orlando, V., Ovchinnikov, D. A., Passier, R., Patrikakis, M., Pombo, A., Pradhan-Bhatt, S., Qin, X. Y., Rehli, M., Rizzu, P., Roy, S., Sajantila, A., Sakaguchi, S., Sato, H., Satoh, H., Savvi, S., Saxena, A., Schmidl, C., Schneider, C., Schulze-Tanzil, G. G., Schwegmann, A., Sheng, G., Shin, J. W., Sugiyama, D., Sugiyama, T., Summers, K. M., Takahashi, N., Takai, J., Tanaka, H., Tatsukawa, H., Tomoiu, A., Toyoda, H., Wetering, M., Berg, L. M. V. D., Verardo, R., Vijayan, DI., Wells, C. A., Winteringham, L. N., Wolvetang, E., Yamaguchi, Y., Yamamoto, M., Yanagi-Mizuochi, C., Yoneda, M., Yonekura, Y., Zhang, P. G., Zucchelli, S., Abugessaisa, I., Arner, E., Harshbarger, J., Kondo, A., Lassmann, T., Lizio, M., Sahin, S., Sengstag, T., Severin, J., Shimoji, H., Suzuki, M., Suzuki, H., Kawai, J., Kondo, N., Itoh, M., Daub, C. O., Kasukawa, T., Kawaji, H., Carninci, P., Forrest, A. R. R. & Hayashizaki, Y., 29 Aug 2017, In : Scientific Data. 4, 170112.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Gene Expression Profile
Gene expression
Mouse
Transcription
Cell
11 Citations (Scopus)
68 Downloads (Pure)

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R., 12 Dec 2017, In : Stem cell reports. 9, 6, p. 1754-1764 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Stem cells
Cell Differentiation
Stem Cells
Bone Morphogenetic Protein 4
46 Citations (Scopus)
46 Downloads (Pure)

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L., 2017, In : Biochemical and biophysical research communications. 482, 2, p. 323-328 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Bioassay
Lab-On-A-Chip Devices
Biological Assay
Molecules
Microfluidics
54 Citations (Scopus)
30 Downloads (Pure)

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L., 15 Mar 2017, In : Development (Cambridge). 144, 6, p. 1008-1017 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Pluripotent Stem Cells
Cardiac Myocytes
Endothelial Cells
Endothelium
Induced Pluripotent Stem Cells
1 Downloads (Pure)

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

Van Eldik, W., Den Adel, B., Monshouwer-Kloots, J. J., Salvatori, D., Maas, S., Van Der Made, I., Creemers, E. E., Frank, D., Frey, N., Boontje, N., Van Der Velden, J., Steendijk, P., Mummery, C., Passier, R. & Beqqali, A., 1 Dec 2017, In : PLoS ONE. 12, 12, e0189139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cardiomyopathy
Cardiomyopathies
actin
Actins
heart
2016
20 Citations (Scopus)
38 Downloads (Pure)

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors

den Hartogh, S. C., Wolstencroft, K., Mummery, C. L. & Passier, R., 19 Jan 2016, In : Scientific reports. 6, 19386.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mesoderm
Gene Expression
Pluripotent Stem Cells
Neoplastic Stem Cells
Gene Regulatory Networks
Biomedical Technology Assessment
Health
Technology
Pharmaceutical Preparations
Decision Support Techniques
30 Citations (Scopus)
44 Downloads (Pure)

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K-L. & Sinnecker, D., 2016, In : European heart journal. 38, 4, p. 292–301

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Drug Design
Cardiac Myocytes
Action Potentials
Romano-Ward Syndrome
21 Citations (Scopus)
8 Downloads (Pure)

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., Kutalik, Z. & 9 othersde Vries, A. A. F., Rivard, L., Wilde, A. A. M., Talajic, M., Verkerk, A. O., Al-Gazali, L., Rioux, J. D., Bhuiyan, Z. A. & Passier, R., 1 Dec 2016, In : EMBO molecular medicine. 8, 12, p. 1390-1408 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Induced Pluripotent Stem Cells
Cardiac Arrhythmias
Cardiac Myocytes
Genes
Flecainide
2015
11 Citations (Scopus)

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure

Kosmidis, G., Bellin, M., Ribeiro, M. C., van Meer, B., Ward-van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S., 27 Nov 2015, In : Biochemical and biophysical research communications. 467, 4, p. 998-1005 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stem cells
Cardiac Myocytes
Dexamethasone
Glucocorticoids
Calcium
52 Citations (Scopus)

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

Birket, M. J., Ribeiro, M. C., Kosmidis, G., Ward, D., Leitoguinho, A. R., van de Pol, V., Dambrot, C., Devalla, H. D., Davis, R. P., Mastroberardino, P. G., Atsma, D. E., Passier, R. & Mummery, C. L., 27 Oct 2015, In : Cell reports. 13, 4, p. 733-745 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Hypertrophic Cardiomyopathy
Stem cells
Cardiac Myocytes
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
94 Citations (Scopus)

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

Birket, M. J., Ribeiro, M. C., Verkerk, A. O., Ward, D., Leitoguinho, A. R., Den Hartogh, S. C., Orlova, V. V., Devalla, H. D., Schwach, V., Bellin, M., Passier, R. & Mummery, C. L., 10 Sep 2015, In : Nature biotechnology. 33, 9, p. 970-979 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pluripotent Stem Cells
Stem cells
Bearings (structural)
Stem Cells
Cardiac Myocytes
95 Citations (Scopus)
1 Downloads (Pure)

Functional maturation of human pluripotent stem cell derived cardiomyocytes invitro - Correlation between contraction force andelectrophysiology

Ribeiro, M. C., Tertoolen, L. G., Guadix, J. A., Bellin, M., Kosmidis, G., D'Aniello, C., Monshouwer-Kloots, J., Goumans, M. J., Wang, Y. L., Feinberg, A. W., Mummery, C. L. & Passier, R., 1 Jan 2015, In : Biomaterials. 51, p. 138-150 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Electrophysiology
Membranes
234 Citations (Scopus)

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

27 Feb 2015, In : Science. 347, 6225, p. 1010-1014 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Transcription Factors
Gene Regulatory Networks
Binding Sites
RNA
Messenger RNA
47 Citations (Scopus)
2 Downloads (Pure)

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

Van Den Berg, C. W., Okawa, S., Chuva De Sousa Lopes, S. M., Van Iperen, L., Passier, R., Braam, S. R., Tertoolen, L. G., Del Sol, A., Davis, R. P. & Mummery, C. L., 23 Sep 2015, In : Development (Cambridge). 142, 18, p. 3231-3238 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Fetal Heart
Pluripotent Stem Cells
Transcriptome
Cardiac Myocytes
Second Pregnancy Trimester
2010
29 Citations (Scopus)
4 Downloads (Pure)

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function

Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A., Mummery, C. & Passier, R., 1 Apr 2010, In : Journal of cell science. 123, 7, p. 1141-1150 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actins
Myocardium
Skeletal Muscle
Proteins
Muscle Development
50 Citations (Scopus)
4 Downloads (Pure)

Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes

Van Laake, L. W., Van Donselaar, E. G., Monshouwer-Kloots, J., Schreurs, C., Passier, R., Humbel, B. M., Doevendans, P. A., Sonnenberg, A., Verkleij, A. J. & Mummery, C. L., 1 Jan 2010, In : Cellular and Molecular Life Sciences. 67, 2, p. 277-290 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cardiac Myocytes
Extracellular Matrix
Transplantation
Fibronectins
Integrins
26 Citations (Scopus)
17 Downloads (Pure)

Sox2 Transduction enhances cardiovascular repair capacity of blood-derived mesoangioblasts

Koyanagi, M., Iwasaki, M., Rupp, S., Tedesco, F. S., Yoon, C. H., Boeckel, J. N., Trauth, J., Schütz, C., Ohtani, K., Goetz, R., Iekushi, K., Bushoven, P., Momma, S., Mummery, C., Passier, R., Henschler, R., Akintuerk, H., Schranz, D., Urbich, C., Galvez, B. G. & 3 othersCossu, G., Zeiher, A. M. & Dimmeler, S., 1 Apr 2010, In : Circulation research. 106, 7, p. 1290-1302 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cell- and Tissue-Based Therapy
Cardiac Myocytes
Endothelial Cells
Myocardial Infarction
Adult Stem Cells
2007
756 Citations (Scopus)

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

1 Jan 2007, In : Nature biotechnology. 25, 7, p. 803-816 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antigens
Stem cells
Stem Cells
Genes
Cell Line