Research Output per year
Research Output
2020
Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications
Jooybar, E., Abdekhodaie, M. J., Karperien, M., Mousavi, A., Alvi, M. & Dijkstra, P. J., 1 Feb 2020, In : International journal of biological macromolecules. 144, p. 837-846 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
1
Citation
(Scopus)
24
Downloads
(Pure)
ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease
Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 1 Apr 2020, In : Cellular Signalling. 68, 109471.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation
van Loo, B., Salehi, S. S., Henke, S., Shamloo, A., Kamperman, T., Karperien, M. & Leijten, J., Mar 2020, In : Materials Today Bio. 6, 100047.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells
Gluscevic, M., Paradise, C. R., Dudakovic, A., Karperien, M., Dietz, A. B., van Wijnen, A. J. & Deyle, D. R., 5 May 2020, In : Gene. 737, 7 p., 144437.Research output: Contribution to journal › Article › Academic › peer-review
1
Citation
(Scopus)
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2
Dudakovic, A., Samsonraj, R. M., Paradise, C. R., Galeano-Garces, C., Mol, M. O., Galeano-Garces, D., Zan, P., Galvan, M. L., Hevesi, M., Pichurin, O., Thaler, R., Begun, D. L., Kloen, P., Karperien, M., Larson, A. N., Westendorf, J. J., Cool, S. M. & van Wijnen, A. J., 5 Jun 2020, In : The Journal of biological chemistry. 295, 23, p. 7877-7893 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage
Paggi, C. A., Venzac, B., Karperien, M., J., L. & le Gac, S., 13 Mar 2020, In : Sensors and actuators. B: Chemical. 315, 127917.Research output: Contribution to journal › Article › Academic › peer-review
Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation
Ooi, H. W., Kocken, J. M. M., Morgan, F. L. C., Malheiro, A., Zoetebier, B., Karperien, M., Wieringa, P. A., Dijkstra, P. J., Moroni, L. & Baker, M. B., 8 Jun 2020, In : Biomacromolecules. 21, 6, p. 2208-2217 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
2019
An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells
Jooybar, E., Abdekhodaie, M. J., Alvi, M., Karperien, M. & Dijkstra, P. J., 1 Jan 2019, In : Acta biomaterialia. 83, p. 233-244 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Cartilage-on-chip: a physiologically inspired platform to reproduce articular joint compression and shear strain
Paggi, C. A., Venzac, B., J., L., Moreira Teixeira Leijten, L. S., Karperien, M. & le Gac, S., 27 Oct 2019.Research output: Contribution to conference › Poster
Changes in Fluorescence Recovery After Photobleaching (FRAP) as an indicator of SOX9 transcription factor activity
Govindaraj, K., Hendriks, J., Lidke, D. S., Karperien, M. & Post, J. N., Jan 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 1, p. 107-117 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
1
Citation
(Scopus)
81
Downloads
(Pure)
Defining the baseline transcriptional fingerprint of rabbit hamstring autograft
Hevesi, M., Paradise, C. R., Paggi, C. A., Galeano-Garces, C., Dudakovic, A., Karperien, M., Kakar, S., Hewett, T. E., Krych, A. J., van Wijnen, A. J. & Saris, D. B. F., 1 Jun 2019, In : Gene Reports. 15, 100363.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
2
Citations
(Scopus)
8
Downloads
(Pure)
Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension
Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Ezh2 inhibition primes BMP2-mediated osteogenic differentiation and bone healing
Dudakovic, A., Samsonraj, R., Paradise, C., Galeano-Garces, C., Mol, M., Galeano-Garces, D., Galvan, M. L., Thaler, R., Larson, A. N., Westendorf, J., van Wijnen, A., Zan, P., Begun, D., Kloen, P. & Karperien, M., Dec 2019, In : Journal of bone and mineral research. 34, S1, p. 229-229 SUN-468.Research output: Contribution to journal › Meeting Abstract › Academic
In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression
Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194Research output: Contribution to journal › Meeting Abstract › Academic
In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load
Spitters, T. W. G. M., Stamatialis, D., Petit, A., De Leeuw, M. G. W. & Karperien, M., 6 Jun 2019, In : Assay and Drug Development Technologies. 17, 4, p. 191-200 10 p.Research output: Contribution to journal › Article › Academic › peer-review
1
Citation
(Scopus)
MICROFABRICATION TECHNOLOGIES FOR CARTILAGE REPAIR
Karperien, M., Jun 2019, In : Annals of the rheumatic diseases. 78, Suppl 2, p. 46-46 SP0151.Research output: Contribution to journal › Meeting Abstract › Academic
Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets
Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.Research output: Contribution to journal › Article › Academic › peer-review
1
Citation
(Scopus)
1
Downloads
(Pure)
Mimicking the Articular Joint with In Vitro Models
Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., Leijten, J., van Weeren, R. & Malda, J., 1 Oct 2019, In : Trends in biotechnology. 37, 10, p. 1063-1077 15 p.Research output: Contribution to journal › Review article › Academic › peer-review
2
Citations
(Scopus)
On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials
Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.Research output: Contribution to journal › Article › Academic › peer-review
2
Citations
(Scopus)
3
Downloads
(Pure)
Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers
Peng, H., Huang, X., Melle, A., Karperien, M. & Pich, A., 22 Mar 2019, In : Journal of colloid and interface science. 540, p. 612-622 11 p.Research output: Contribution to journal › Article › Academic › peer-review
11
Citations
(Scopus)
Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs
Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
1
Citation
(Scopus)
54
Downloads
(Pure)
The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity
Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.Research output: Contribution to journal › Article › Academic › peer-review
1
Citation
(Scopus)
2018
A new method for multiplex measurements of biomarkers in synovial fluid aspirates with high sensitivity and extensive quality control
Hendriks, J., Saris, D. & Karperien, M., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S193-S193 374.Research output: Contribution to journal › Meeting Abstract › Academic
An important step towards a prevascularized islet macroencapsulation device: Effect of micropatterned membranes on development of endothelial cell network
Skrzypek, K., Nibbelink, M. G., Karbaat, L. P., Karperien, M., van Apeldoorn, A. & Stamatialis, D., 1 Jul 2018, In : Journal of Materials Science: Materials in Medicine. 29, 7, 91.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
8
Citations
(Scopus)
30
Downloads
(Pure)
An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes
Groot Nibbelink, M., Skrzypek, K., Karbaat, L., Both, S., Plass, J., Klomphaar, B., van Lente, J., Henke, S., Karperien, M., Stamatialis, D. & van Apeldoorn, A., 1 Nov 2018, In : Journal of Materials Science: Materials in Medicine. 29, 11, 174.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
3
Citations
(Scopus)
39
Downloads
(Pure)
Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments
Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
3
Citations
(Scopus)
31
Downloads
(Pure)
Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis
Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice
Dudakovic, A., Camilleri, E. T., Paradise, C. R., Samsonraj, R. M., Gluscevic, M., Paggi, C. A., Begun, D. L., Khani, F., Pichurin, O., Ahmed, F. S., Elsayed, R., Elsalanty, M., McGee-Lawrence, M. E., Karperien, M., Riester, S. M., Thaler, R., Westendorf, J. J. & van Wijnen, A. J., 17 Aug 2018, In : Journal of biological chemistry. 293, 33, p. 12894-12907 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
9
Citations
(Scopus)
29
Downloads
(Pure)
Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells
Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
1
Citation
(Scopus)
41
Downloads
(Pure)
Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6
Cabanas-Danés, J., Landman, E., Huskens, J., Karperien, M. & Jonkheijm, P., 7 Aug 2018, In : Langmuir. 34, 31, p. 9298-9306 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials
Visser, C. W., Kamperman, T., Karbaat, L. P., Lohse, D. & Karperien, M., 1 Jan 2018, In : Science advances. 4, 1, eaao1175.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
33
Citations
(Scopus)
81
Downloads
(Pure)
Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affectcartilage development
Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H-J., Karperien, M., Krych, A. J., Westendorf, J. J., Larson, A. N. & van Wijnen, A. J., 7 Dec 2018, In : Journal of biological chemistry. 293, p. 19001-19011 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
Membranes for bioartificial pancreas: Macroencapsulation strategies
Skrzypek, K., Groot Nibbelink, M., Karperien, M., van Apeldoorn, A. & Stamatialis, D., Jan 2018, Biomedical Membranes And (Bio)artificial Organs. World Scientific Publishing Co. Pte Ltd, p. 211-244 34 p. (World Scientific Series in Membrane Science and Technology: Biological and Biomimetic Applications, Energy and the Environment; vol. 2).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
Mitochondrial changes of articular chondrocytes revealed by omics analyses
Bakker, B., Eijkel, G., Mohren, R., Heeren, R., Karperien, M., Post, J. & Cillero-Pastor, B., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S170-S171 332.Research output: Contribution to journal › Meeting Abstract › Academic
Molecular characterization of physis tissue by RNA sequencing
Paradise, C. R., Galeano-Garces, C., Galeano-Garces, D., Dudakovic, A., Milbrandt, T. A., Saris, D. B. F., Krych, A. J., Karperien, M., Ferguson, G. B., Evseenko, D., Riester, S. M., van Wijnen, A. J. & Noelle Larson, A., 20 Aug 2018, In : Gene. 668, p. 87-96 10 p.Research output: Contribution to journal › Article › Academic › peer-review
6
Citations
(Scopus)
Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging
Hendriks, J., Stojanovic, I., Schasfoort, R. B. M., Saris, D. B. F. & Karperien, M., 5 Jun 2018, In : Analytical chemistry. 90, 11, p. 6563-6571 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
3
Citations
(Scopus)
27
Downloads
(Pure)
Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds
Huang, X., Hou, Y., Zhong, L., Huang, D., Qian, H., Karperien, M. & Chen, W., 8 Jan 2018, In : Biomacromolecules. 19, 1, p. 94-102 9 p.Research output: Contribution to journal › Article › Academic › peer-review
15
Citations
(Scopus)
RUNX2 and SOX9 protein mobility correlates to osteogenic and chondrogenic differentiation of mesenchymal stem cells
Khurana, S., Govindaraj, K., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S109-S110 201.Research output: Contribution to journal › Meeting Abstract › Academic
Single-Cell Microgels: Technology, Challenges, and Applications
Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
15
Citations
(Scopus)
114
Downloads
(Pure)
SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes
Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S106-S107 195.Research output: Contribution to journal › Meeting Abstract › Academic
The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells
Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
7
Citations
(Scopus)
57
Downloads
(Pure)
Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture
Pleumeekers, M. M., Nimeskern, L., Koevoet, J. L. M., Karperien, M., Stok, K. S. & van Osch, G. J. V. M., 28 Feb 2018, In : PLoS ONE. 13, 2, e0190744.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
11
Citations
(Scopus)
52
Downloads
(Pure)
Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics
Kamperman, T., Trikalitis, V. D., Karperien, M., Visser, C. W. & Leijten, J., 18 Jul 2018, In : ACS Applied Materials and Interfaces. 10, 28, p. 23433-23438 6 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
12
Citations
(Scopus)
88
Downloads
(Pure)
2017
Amyloid micronetworks for cartilage repair
van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.Research output: Contribution to journal › Meeting Abstract › Academic
A new highly sensitive method for multiplex measurements of biomarkers in synovial fluid aspirates
Hendriks, J., Stojanovic, I., Saris, D. B. & Karperien, M., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S99-S99 129.Research output: Contribution to journal › Meeting Abstract › Academic
Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles
Dijkstra, K., Hendriks, J., Karperien, M., Vonk, L. A. & Saris, D. B. F., 1 Sep 2017, In : Tissue engineering. Part C: Methods. 23, 9, p. 505-515 11 p.Research output: Contribution to journal › Article › Academic › peer-review
4
Citations
(Scopus)
1
Downloads
(Pure)
Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape
Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
20
Citations
(Scopus)
112
Downloads
(Pure)
Computational Modeling of Complex Protein Activity Networks
Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
Open Access
File
High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes
Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.Research output: Contribution to journal › Meeting Abstract › Academic
Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization
Marchioli, G., Zellner, L., Oliveira, C., Engelse, M., de Koning, E., Mano, J. F., Karperien, H. B. J., Apeldoorn, A. V. & Moroni, L., 1 Dec 2017, In : Journal of materials science. Materials in medicine. 28, 12, 195.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
File
12
Citations
(Scopus)
55
Downloads
(Pure)