H.B.J. Karperien

prof.dr.

  • 5454 Citations
  • 40 h-Index
20072020

Research output per year

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Research Output

2020

Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

Jooybar, E., Abdekhodaie, M. J., Karperien, M., Mousavi, A., Alvi, M. & Dijkstra, P. J., 1 Feb 2020, In : International journal of biological macromolecules. 144, p. 837-846 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
24 Downloads (Pure)

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 1 Apr 2020, In : Cellular Signalling. 68, 109471.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Downloads (Pure)

Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation

van Loo, B., Salehi, S. S., Henke, S., Shamloo, A., Kamperman, T., Karperien, M. & Leijten, J., Mar 2020, In : Materials Today Bio. 6, 100047.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Downloads (Pure)

Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells

Gluscevic, M., Paradise, C. R., Dudakovic, A., Karperien, M., Dietz, A. B., van Wijnen, A. J. & Deyle, D. R., 5 May 2020, In : Gene. 737, 7 p., 144437.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

Dudakovic, A., Samsonraj, R. M., Paradise, C. R., Galeano-Garces, C., Mol, M. O., Galeano-Garces, D., Zan, P., Galvan, M. L., Hevesi, M., Pichurin, O., Thaler, R., Begun, D. L., Kloen, P., Karperien, M., Larson, A. N., Westendorf, J. J., Cool, S. M. & van Wijnen, A. J., 5 Jun 2020, In : The Journal of biological chemistry. 295, 23, p. 7877-7893 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation

Ooi, H. W., Kocken, J. M. M., Morgan, F. L. C., Malheiro, A., Zoetebier, B., Karperien, M., Wieringa, P. A., Dijkstra, P. J., Moroni, L. & Baker, M. B., 8 Jun 2020, In : Biomacromolecules. 21, 6, p. 2208-2217 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2019

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells

Jooybar, E., Abdekhodaie, M. J., Alvi, M., Karperien, M. & Dijkstra, P. J., 1 Jan 2019, In : Acta biomaterialia. 83, p. 233-244 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
17 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
81 Downloads (Pure)

Defining the baseline transcriptional fingerprint of rabbit hamstring autograft

Hevesi, M., Paradise, C. R., Paggi, C. A., Galeano-Garces, C., Dudakovic, A., Karperien, M., Kakar, S., Hewett, T. E., Krych, A. J., van Wijnen, A. J. & Saris, D. B. F., 1 Jun 2019, In : Gene Reports. 15, 100363.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
51 Downloads (Pure)

Ezh2 inhibition primes BMP2-mediated osteogenic differentiation and bone healing

Dudakovic, A., Samsonraj, R., Paradise, C., Galeano-Garces, C., Mol, M., Galeano-Garces, D., Galvan, M. L., Thaler, R., Larson, A. N., Westendorf, J., van Wijnen, A., Zan, P., Begun, D., Kloen, P. & Karperien, M., Dec 2019, In : Journal of bone and mineral research. 34, S1, p. 229-229 SUN-468.

Research output: Contribution to journalMeeting AbstractAcademic

1 Citation (Scopus)

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194

Research output: Contribution to journalMeeting AbstractAcademic

In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load

Spitters, T. W. G. M., Stamatialis, D., Petit, A., De Leeuw, M. G. W. & Karperien, M., 6 Jun 2019, In : Assay and Drug Development Technologies. 17, 4, p. 191-200 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

MICROFABRICATION TECHNOLOGIES FOR CARTILAGE REPAIR

Karperien, M., Jun 2019, In : Annals of the rheumatic diseases. 78, Suppl 2, p. 46-46 SP0151.

Research output: Contribution to journalMeeting AbstractAcademic

Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets

Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)

Mimicking the Articular Joint with In Vitro Models

Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., Leijten, J., van Weeren, R. & Malda, J., 1 Oct 2019, In : Trends in biotechnology. 37, 10, p. 1063-1077 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
3 Downloads (Pure)

Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers

Peng, H., Huang, X., Melle, A., Karperien, M. & Pich, A., 22 Mar 2019, In : Journal of colloid and interface science. 540, p. 612-622 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
54 Downloads (Pure)

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2018

A new method for multiplex measurements of biomarkers in synovial fluid aspirates with high sensitivity and extensive quality control

Hendriks, J., Saris, D. & Karperien, M., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S193-S193 374.

Research output: Contribution to journalMeeting AbstractAcademic

An important step towards a prevascularized islet macroencapsulation device: Effect of micropatterned membranes on development of endothelial cell network

Skrzypek, K., Nibbelink, M. G., Karbaat, L. P., Karperien, M., van Apeldoorn, A. & Stamatialis, D., 1 Jul 2018, In : Journal of Materials Science: Materials in Medicine. 29, 7, 91.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
30 Downloads (Pure)

An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes

Groot Nibbelink, M., Skrzypek, K., Karbaat, L., Both, S., Plass, J., Klomphaar, B., van Lente, J., Henke, S., Karperien, M., Stamatialis, D. & van Apeldoorn, A., 1 Nov 2018, In : Journal of Materials Science: Materials in Medicine. 29, 11, 174.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
39 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
31 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
34 Downloads (Pure)

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

Dudakovic, A., Camilleri, E. T., Paradise, C. R., Samsonraj, R. M., Gluscevic, M., Paggi, C. A., Begun, D. L., Khani, F., Pichurin, O., Ahmed, F. S., Elsayed, R., Elsalanty, M., McGee-Lawrence, M. E., Karperien, M., Riester, S. M., Thaler, R., Westendorf, J. J. & van Wijnen, A. J., 17 Aug 2018, In : Journal of biological chemistry. 293, 33, p. 12894-12907 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Citations (Scopus)
29 Downloads (Pure)

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
41 Downloads (Pure)

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6

Cabanas-Danés, J., Landman, E., Huskens, J., Karperien, M. & Jonkheijm, P., 7 Aug 2018, In : Langmuir. 34, 31, p. 9298-9306 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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29 Downloads (Pure)

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials

Visser, C. W., Kamperman, T., Karbaat, L. P., Lohse, D. & Karperien, M., 1 Jan 2018, In : Science advances. 4, 1, eaao1175.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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33 Citations (Scopus)
81 Downloads (Pure)

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affectcartilage development

Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H-J., Karperien, M., Krych, A. J., Westendorf, J. J., Larson, A. N. & van Wijnen, A. J., 7 Dec 2018, In : Journal of biological chemistry. 293, p. 19001-19011 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
6 Citations (Scopus)
15 Downloads (Pure)

Membranes for bioartificial pancreas: Macroencapsulation strategies

Skrzypek, K., Groot Nibbelink, M., Karperien, M., van Apeldoorn, A. & Stamatialis, D., Jan 2018, Biomedical Membranes And (Bio)artificial Organs. World Scientific Publishing Co. Pte Ltd, p. 211-244 34 p. (World Scientific Series in Membrane Science and Technology: Biological and Biomimetic Applications, Energy and the Environment; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Mitochondrial changes of articular chondrocytes revealed by omics analyses

Bakker, B., Eijkel, G., Mohren, R., Heeren, R., Karperien, M., Post, J. & Cillero-Pastor, B., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S170-S171 332.

Research output: Contribution to journalMeeting AbstractAcademic

Molecular characterization of physis tissue by RNA sequencing

Paradise, C. R., Galeano-Garces, C., Galeano-Garces, D., Dudakovic, A., Milbrandt, T. A., Saris, D. B. F., Krych, A. J., Karperien, M., Ferguson, G. B., Evseenko, D., Riester, S. M., van Wijnen, A. J. & Noelle Larson, A., 20 Aug 2018, In : Gene. 668, p. 87-96 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging

Hendriks, J., Stojanovic, I., Schasfoort, R. B. M., Saris, D. B. F. & Karperien, M., 5 Jun 2018, In : Analytical chemistry. 90, 11, p. 6563-6571 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
27 Downloads (Pure)

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds

Huang, X., Hou, Y., Zhong, L., Huang, D., Qian, H., Karperien, M. & Chen, W., 8 Jan 2018, In : Biomacromolecules. 19, 1, p. 94-102 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

RUNX2 and SOX9 protein mobility correlates to osteogenic and chondrogenic differentiation of mesenchymal stem cells

Khurana, S., Govindaraj, K., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S109-S110 201.

Research output: Contribution to journalMeeting AbstractAcademic

7 Citations (Scopus)

Single-Cell Microgels: Technology, Challenges, and Applications

Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
15 Citations (Scopus)
114 Downloads (Pure)

SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes

Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S106-S107 195.

Research output: Contribution to journalMeeting AbstractAcademic

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
57 Downloads (Pure)

Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture

Pleumeekers, M. M., Nimeskern, L., Koevoet, J. L. M., Karperien, M., Stok, K. S. & van Osch, G. J. V. M., 28 Feb 2018, In : PLoS ONE. 13, 2, e0190744.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
52 Downloads (Pure)
Open Access
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12 Citations (Scopus)
88 Downloads (Pure)
2017

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

A new highly sensitive method for multiplex measurements of biomarkers in synovial fluid aspirates

Hendriks, J., Stojanovic, I., Saris, D. B. & Karperien, M., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S99-S99 129.

Research output: Contribution to journalMeeting AbstractAcademic

33 Citations (Scopus)

Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles

Dijkstra, K., Hendriks, J., Karperien, M., Vonk, L. A. & Saris, D. B. F., 1 Sep 2017, In : Tissue engineering. Part C: Methods. 23, 9, p. 505-515 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
1 Downloads (Pure)

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
112 Downloads (Pure)

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
File
91 Downloads (Pure)

High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.

Research output: Contribution to journalMeeting AbstractAcademic

15 Citations (Scopus)

Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization

Marchioli, G., Zellner, L., Oliveira, C., Engelse, M., de Koning, E., Mano, J. F., Karperien, H. B. J., Apeldoorn, A. V. & Moroni, L., 1 Dec 2017, In : Journal of materials science. Materials in medicine. 28, 12, 195.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
12 Citations (Scopus)
55 Downloads (Pure)