H.B.J. Karperien

prof.dr.

  • 4995 Citations
  • 39 h-Index
20072019
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Research Output 2007 2019

2019
10 Citations (Scopus)
33 Downloads (Pure)

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells

Jooybar, E., Abdekhodaie, M. J., Alvi, M., Karperien, M. & Dijkstra, P. J., 1 Jan 2019, In : Acta biomaterialia. 83, p. 233-244 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrogenesis
Hyaluronic acid
Tyramine
Hydrogel
Hyaluronic Acid
56 Downloads (Pure)
Open Access
File
SOX9 Transcription Factor
Fluorescence Recovery After Photobleaching
Photobleaching
Transcription Factors
Fluorescence
2 Citations (Scopus)

Defining the baseline transcriptional fingerprint of rabbit hamstring autograft

Hevesi, M., Paradise, C. R., Paggi, C. A., Galeano-Garces, C., Dudakovic, A., Karperien, M., Kakar, S., Hewett, T. E., Krych, A. J., van Wijnen, A. J. & Saris, D. B. F., 1 Jun 2019, In : Gene Reports. 15, 100363.

Research output: Contribution to journalArticleAcademicpeer-review

Autografts
Dermatoglyphics
Decorin
Tendons
Rabbits
29 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Oxygen
Cartilage Diseases
Matrix Metalloproteinases
Cartilage
3 Downloads (Pure)

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 11 Dec 2019, In : Cellular Signalling.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Joints
Interleukin-1beta
Computer Simulation
Cartilage

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194

Research output: Contribution to journalMeeting AbstractAcademic

In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load

Spitters, T. W. G. M., Stamatialis, D., Petit, A., De Leeuw, M. G. W. & Karperien, M., 6 Jun 2019, In : Assay and Drug Development Technologies. 17, 4, p. 191-200 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Articular Cartilage
Bromphenol Blue
Pharmaceutical Preparations
Synovial Fluid
Bioreactors

MICROFABRICATION TECHNOLOGIES FOR CARTILAGE REPAIR

Karperien, M., Jun 2019, In : Annals of the rheumatic diseases. 78, Suppl 2, p. 46-46 SP0151.

Research output: Contribution to journalMeeting AbstractAcademic

1 Downloads (Pure)

Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets

Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Insulin
Laminin
Scaffolds (biology)
Collagen
Scaffolds
1 Citation (Scopus)

Mimicking the Articular Joint with In Vitro Models

Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., Leijten, J., van Weeren, R. & Malda, J., 1 Oct 2019, In : Trends in biotechnology. 37, 10, p. 1063-1077 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Joints
Joint Diseases
Animals
Animal Models
In Vitro Techniques
2 Downloads (Pure)

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lab-On-A-Chip Devices
Microfluidics
Nozzles
Oils
Microtechnology
7 Citations (Scopus)

Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers

Peng, H., Huang, X., Melle, A., Karperien, M. & Pich, A., 22 Mar 2019, In : Journal of colloid and interface science. 540, p. 612-622 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prodrugs
Drug delivery
Crosslinking
Amines
Copolymers
22 Downloads (Pure)

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
biotin
Avidin
Biotin
Complexation
Hydrogels

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Synovial Fluid
Osteoarthritis
Inflammation
Proteins
Fluids
2018

A new method for multiplex measurements of biomarkers in synovial fluid aspirates with high sensitivity and extensive quality control

Hendriks, J., Saris, D. & Karperien, M., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S193-S193 374.

Research output: Contribution to journalMeeting AbstractAcademic

4 Citations (Scopus)
22 Downloads (Pure)
Open Access
File
Endothelial cells
Endothelial Cells
Membranes
Equipment and Supplies
Human Umbilical Vein Endothelial Cells
1 Citation (Scopus)
29 Downloads (Pure)
Open Access
File
Microencapsulation
Drug Compounding
Stem cells
Mesenchymal Stromal Cells
Islets of Langerhans Transplantation
3 Citations (Scopus)
22 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Transforming Growth Factors
Chondrocytes
Osteoarthritis
Oxygen
Gene Expression
4 Citations (Scopus)
21 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Knee Injuries
Synovial Fluid
Osteoarthritis
Proteins
Fluids
7 Citations (Scopus)
21 Downloads (Pure)

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

Dudakovic, A., Camilleri, E. T., Paradise, C. R., Samsonraj, R. M., Gluscevic, M., Paggi, C. A., Begun, D. L., Khani, F., Pichurin, O., Ahmed, F. S., Elsayed, R., Elsalanty, M., McGee-Lawrence, M. E., Karperien, M., Riester, S. M., Thaler, R., Westendorf, J. J. & van Wijnen, A. J., 17 Aug 2018, In : Journal of biological chemistry. 293, 33, p. 12894-12907 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Osteogenesis
Cell Cycle
Bone
Cells
Osteoblasts
20 Downloads (Pure)

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Printing
Insulin
Fibronectins
Collagen
Extracellular Matrix
21 Downloads (Pure)

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6

Cabanas-Danés, J., Landman, E., Huskens, J., Karperien, M. & Jonkheijm, P., 7 Aug 2018, In : Langmuir. 34, 31, p. 9298-9306 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
activity (biology)
Bioactivity
bones
Bone
Siloxanes
27 Citations (Scopus)
66 Downloads (Pure)

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials

Visser, C. W., Kamperman, T., Karbaat, L. P., Lohse, D. & Karperien, M., 1 Jan 2018, In : Science advances. 4, 1, eaao1175.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Emulsions
Suspensions
Air
Cellular Microenvironment
3 Citations (Scopus)
7 Downloads (Pure)

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affectcartilage development

Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H-J., Karperien, M., Krych, A. J., Westendorf, J. J., Larson, A. N. & van Wijnen, A. J., 7 Dec 2018, In : Journal of biological chemistry. 293, p. 19001-19011 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Bone
Genes
Histology
Osteoblasts

Membranes for bioartificial pancreas: Macroencapsulation strategies

Skrzypek, K., Groot Nibbelink, M., Karperien, M., van Apeldoorn, A. & Stamatialis, D., Jan 2018, Biomedical Membranes And (Bio)artificial Organs. World Scientific Publishing Co. Pte Ltd, p. 211-244 34 p. (World Scientific Series in Membrane Science and Technology: Biological and Biomimetic Applications, Energy and the Environment).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Medical problems
Pancreas
Membranes
Equipment and Supplies

Mitochondrial changes of articular chondrocytes revealed by omics analyses

Bakker, B., Eijkel, G., Mohren, R., Heeren, R., Karperien, M., Post, J. & Cillero-Pastor, B., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S170-S171 332.

Research output: Contribution to journalMeeting AbstractAcademic

4 Citations (Scopus)

Molecular characterization of physis tissue by RNA sequencing

Paradise, C. R., Galeano-Garces, C., Galeano-Garces, D., Dudakovic, A., Milbrandt, T. A., Saris, D. B. F., Krych, A. J., Karperien, M., Ferguson, G. B., Evseenko, D., Riester, S. M., van Wijnen, A. J. & Noelle Larson, A., 20 Aug 2018, In : Gene. 668, p. 87-96 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

RNA Sequence Analysis
Growth Disorders
Growth Plate
Matrilin Proteins
Bone Development
3 Citations (Scopus)
11 Downloads (Pure)

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging

Hendriks, J., Stojanovic, I., Schasfoort, R. B. M., Saris, D. B. F. & Karperien, M., 5 Jun 2018, In : Analytical chemistry. 90, 11, p. 6563-6571 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Surface plasmon resonance
Biomarkers
Nanoparticles
Imaging techniques
Fluids
11 Citations (Scopus)

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds

Huang, X., Hou, Y., Zhong, L., Huang, D., Qian, H., Karperien, M. & Chen, W., 8 Jan 2018, In : Biomacromolecules. 19, 1, p. 94-102 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogel
Stem cells
Hydrogels
Scaffolds
Gene expression
5 Citations (Scopus)

RUNX2 and SOX9 protein mobility correlates to osteogenic and chondrogenic differentiation of mesenchymal stem cells

Khurana, S., Govindaraj, K., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S109-S110 201.

Research output: Contribution to journalMeeting AbstractAcademic

10 Citations (Scopus)
48 Downloads (Pure)

Single-Cell Microgels: Technology, Challenges, and Applications

Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Technology
Pharmacokinetics
Encapsulation
Screening
Mass transfer

SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes

Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S106-S107 195.

Research output: Contribution to journalMeeting AbstractAcademic

6 Citations (Scopus)
48 Downloads (Pure)

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stem cells
Stem cells
Mesenchymal Stromal Cells
Modulators
modulators
7 Citations (Scopus)
42 Downloads (Pure)

Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture

Pleumeekers, M. M., Nimeskern, L., Koevoet, J. L. M., Karperien, M., Stok, K. S. & van Osch, G. J. V. M., 28 Feb 2018, In : PLoS ONE. 13, 2, e0190744.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
chondrocytes
Cartilage
coculture
Chondrocytes
Coculture Techniques
8 Citations (Scopus)
64 Downloads (Pure)

Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics

Kamperman, T., Trikalitis, V. D., Karperien, M., Visser, C. W. & Leijten, J., 18 Jul 2018, In : ACS Applied Materials and Interfaces. 10, 28, p. 23433-23438 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Microfluidics
Throughput
Air
Gas generators
Consumer electronics
2017

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

27 Citations (Scopus)

A new highly sensitive method for multiplex measurements of biomarkers in synovial fluid aspirates

Hendriks, J., Stojanovic, I., Saris, D. B. & Karperien, M., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S99-S99 129.

Research output: Contribution to journalMeeting AbstractAcademic

2 Citations (Scopus)
1 Downloads (Pure)

Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles

Dijkstra, K., Hendriks, J., Karperien, M., Vonk, L. A. & Saris, D. B. F., 1 Sep 2017, In : Tissue engineering. Part C: Methods. 23, 9, p. 505-515 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
80 Downloads (Pure)

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Crosslinking
Microencapsulation
Cell Culture Techniques
Emulsification
Cell culture
77 Downloads (Pure)

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
File
Computational Modeling
Computer Simulation
Molecular interactions
Proteins
Protein
8 Citations (Scopus)

High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.

Research output: Contribution to journalMeeting AbstractAcademic

9 Citations (Scopus)
46 Downloads (Pure)

Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization

Marchioli, G., Zellner, L., Oliveira, C., Engelse, M., de Koning, E., Mano, J. F., Karperien, H. B. J., Apeldoorn, A. V. & Moroni, L., 1 Dec 2017, In : Journal of materials science. Materials in medicine. 28, 12, 195.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Hydrogel
Islets of Langerhans
Encapsulation
Hydrogels
Intercellular Signaling Peptides and Proteins
9 Citations (Scopus)
61 Downloads (Pure)

Micro-fabricated scaffolds lead to efficient remission of diabetes in mice

Buitinga, M., Assen, F., Hanegraaf, M., Wieringa, P., Hilderink, J., Moroni, L., Truckenmüller, R., van Blitterswijk, C., Römer, G-W., Carlotti, F., de Koning, E., Karperien, M. & van Apeldoorn, A., Aug 2017, In : Biomaterials. 135, p. 10-22

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Medical problems
Scaffolds
Transplantation
Islets of Langerhans
Blood Vessels
9 Citations (Scopus)
54 Downloads (Pure)

Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue–Derived Human Mesenchymal Stromal Cells

Galeano-Garces, C., Camilleri, E. T., Riester, S. M., Dudakovic, A., Larson, D. R., Qu, W., Smith, J., Dietz, A. B., Im, H-J., Krych, A. J., Larson, A. N., Karperien, M. & van Wijnen, A. J., 1 Jul 2017, In : Cartilage. 8, 3, p. 283-299 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Cartilage
Platelets
Mesenchymal Stromal Cells
Blood Platelets
Stem cells
6 Citations (Scopus)
57 Downloads (Pure)

Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets

Kamperman, T., Henke, S., Zoetebier, B., Ruiterkamp, N., Wang, R., Pouran, B., Weinans, H., Karperien, M. & Leijten, J., 2 May 2017, In : Journal of materials chemistry. B: materials for biology and medicine. 5, 25, p. 4835-4844 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Tyramine
Hydrogel
Gelation
Emulsions
Hydrogels
11 Citations (Scopus)
44 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
interleukins
Nitric oxide
nitric oxide
Chondrocytes
Crosstalk
12 Downloads (Pure)

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Welting, T. J. M., Karperien, M. & Post, J. N., 17 Jul 2017, In : Biotarget. 2, 11, 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Cartilage
Growth Plate
Articular Cartilage
Bone and Bones
1 Citation (Scopus)

O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models

Georgi, N., Landman, E. B. M., Klein, T. J., van Blitterswijk, C. A. & Karperien, M., 1 Mar 2017, In : Journal of tissue engineering and regenerative medicine. 11, 3, p. 724-732 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phenanthrolines
Cartilage
Tissue Engineering
Tissue engineering
Modulators
6 Citations (Scopus)
39 Downloads (Pure)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14 Citations (Scopus)
44 Downloads (Pure)

Pancreatic islet macroencapsulation using microwell porous membranes

Skrzypek, K., Groot Nibbelink, M., Van Lente, J., Buitinga, M., Engelse, M. A., De Koning, E. J. P., Karperien, M., Van Apeldoorn, A. & Stamatialis, D., 1 Dec 2017, In : Scientific reports. 7, 1, 9186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Islets of Langerhans
Islets of Langerhans Transplantation
Membranes
Glucose
Equipment and Supplies