Research output per year
Research output per year
- 1 - 50 out of 391 results
Search results
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2025
Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model
Piluso, S., Li, Y., Texeira, L. M., Padmanaban, P., Rouwkema, J., Leijten, J., van Weeren, R., Karperien, M. & Malda, J., Jun 2025, In: Journal of Cartilage and Joint Preservation. 5, 2, 100233.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)26 Downloads (Pure) -
Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides
Zhong, L., Morshuis, L. C. M., Koerselman, M., Memelink, A., Kolecka, A., Heukers, R., Verrips, T., Karperien, M. & Zoetebier, B., 18 Jun 2025, In: Bioconjugate chemistry. 36, 6, p. 1319-1328 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure) -
Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications
Banigo, A. T., Nauta, L., Zoetebier, B. & Karperien, M., 28 Mar 2025, In: Polymers. 17, 7, 48 p., 917.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
The Modified Canine Groove Model of Osteoarthritis †
van der Weiden, G. S., Meij, B. P., van de Belt, A., Custers, R. J. H., Both, S. K., Karperien, M. & Mastbergen, S. C., 9 Apr 2025, In: Biomedicines. 13, 4, 15 p., 913.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
2024
Bioactive Hydrogels Based on Tyramine and Maleimide Functionalized Dextran for Tissue Engineering Applications
Zhong, L., Banigo, A. T., Zoetebier, B. & Karperien, M., 30 Aug 2024, In: Gels. 10, 9, 566.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)167 Downloads (Pure) -
Coaxial Bioprinting of Enzymatically Crosslinkable Hyaluronic Acid-Tyramine Bioinks for Tissue Regeneration
Banigo, A. T., Nauta, L., Zoetebier, B. & Karperien, M., Sept 2024, In: Polymers. 16, 17, 2470.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)146 Downloads (Pure) -
Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model
van der Weiden, G. S., Mastbergen, S. C., Both, S. K., Karperien, M., Lafeber, F. P., van Egmond, N. & Custers, R. J. H., Sept 2024, In: Osteoarthritis and Cartilage Open. 6, 3, 100492.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)138 Downloads (Pure) -
Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis
Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N., Dec 2024, In: Journal of cellular physiology. 239, 12, e31443.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile88 Downloads (Pure) -
Gelatin-tyramine addition and low hydrogel density improves cell attachment, migration, and metabolic activity in vitro and tissue response in vivo in enzymatically crosslinkable dextran-hyaluronic acid hydrogels
Hendriks, J., Zoetebier, B., Larrea, C. S., Le, N. X. T., Saris, D. B. F. & Karperien, M., Feb 2024, In: International journal of biological macromolecules. 259, 11 p., 128843.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)146 Downloads (Pure) -
Microfluidic Generation of Thin-Shelled Polyethylene Glycol-Tyramine Microgels for Non-Invasive Delivery of Immunoprotected β-Cells
Araújo-Gomes, N., Zoetebier-Liszka, B., van Loo, B., Becker, M., Nijhuis, S., Smink, A. M., de Haan, B. J., de Vos, P., Karperien, M. & Leijten, J., 7 Oct 2024, In: Advanced healthcare materials. 13, 25, 13 p., 2301552.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus)91 Downloads (Pure) -
Synthesis and Engineering of Hyaluronic Acid-Gelatin Hydrogels with Improved Cellular Attachment and Growth
Banigo, A. T., Konings, I. B. M., Nauta, L., Zoetebier, B. & Karperien, M., Dec 2024, In: Polymers. 16, 23, 3410.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Downloads (Pure) -
Towards single-cell bioprinting: micropatterning tools for organ-on-chip development
Bosmans, C., Ginés Rodriguez, N., Karperien, M., Malda, J., Moreira Teixeira, L., Levato, R. & Leijten, J., Jun 2024, In: Trends in biotechnology. 42, 6, p. 739-759 21 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile6 Citations (Scopus)130 Downloads (Pure) -
2023
Aggregation and Gelation Behavior of Stereocomplexed Four-Arm PLA-PEG Copolymers Containing Neutral or Cationic Linkers
Signori, F., Wennink, J. W. H., Bronco, S., Feijen, J., Karperien, M., Bizzarri, R. & Dijkstra, P. J., Feb 2023, In: International journal of molecular sciences. 24, 4, 3327.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)116 Downloads (Pure) -
Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging
Araújo-Gomes, N., Zambito, G., Johnbosco, C., Calejo, I., Leijten, J., Löwik, C., Karperien, M., Mezzanotte, L. & Teixeira, L. M., 1 Oct 2023, In: Biosensors and Bioelectronics. 237, 115510.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Citations (Scopus)159 Downloads (Pure) -
Chitosan and carboxymethyl cellulose-based 3D multifunctional bioactive hydrogels loaded with nano-curcumin for synergistic diabetic wound repair
Shah, S. A., Sohail, M., Karperien, M., Johnbosco, C., Mahmood, A. & Kousar, M., 1 Feb 2023, In: International journal of biological macromolecules. 227, p. 1203-1220 18 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile51 Citations (Scopus)823 Downloads (Pure) -
Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration
Dalen, M. C. E. V., Karperien, M., Claessens, M. M. A. E. & Post, J. N., 11 Jul 2023, In: ACS Omega. 8, 27, p. 24198-24209 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)115 Downloads (Pure) -
Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis
Spoelstra, L. R., Araújo-Gomes, N. (Contributor), Zakharova - Kolezhuk, M. (Contributor), Welting, T. J. M. (Contributor), Karperien, M. (Contributor), Segerink, L. (Contributor) & Le Gac, S. (Contributor), 14 Nov 2023.Research output: Contribution to conference › Poster › Academic
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Enzymatic co-crosslinking of star-shaped poly(ethylene glycol) tyramine and hyaluronic acid tyramine conjugates provides elastic biocompatible and biodegradable hydrogels
Wang, R., Huang, X., Zoetebier, B., Dijkstra, P. J. & Karperien, M., Feb 2023, In: Bioactive Materials. 20, p. 53-63 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile37 Citations (Scopus)259 Downloads (Pure) -
Mapping RUNX2 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells
Govindaraj, K., Kannan, S., Karperien, M. & Post, J. N., 30 Mar 2023, bioRxiv.Research output: Working paper › Preprint › Academic
Open AccessFile57 Downloads (Pure) -
Microencapsulated stem cells reduce cartilage damage in a material dependent manner following minimally invasive intra-articular injection in an OA rat model
Johnbosco, C., Karbaat, L., Korthagen, N. M., Warmink, K., Koerselman, M., Coeleveld, K., Becker, M., van Loo, B., Zoetebier, B., Both, S., Weinans, H., Karperien, M. & Leijten, J., Oct 2023, In: Materials Today Bio. 22, 100791.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)105 Downloads (Pure) -
Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli-Responsive Cell-Adhesive Micromaterials
Kamperman, T., Willemen, N. G. A., Kelder, C., Koerselman, M., Becker, M., Lins, L., Johnbosco, C., Karperien, M. & Leijten, J., 5 Apr 2023, In: Advanced science. 10, 10, 2205487.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)135 Downloads (Pure) -
The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine
Koerselman, M., Morshuis, L. C. M. & Karperien, M., 15 Oct 2023, In: Acta biomaterialia. 170, p. 1-14 14 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile7 Citations (Scopus)122 Downloads (Pure) -
2022
Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip
Paggi, C. A., Hendriks, J., Karperien, M. & Gac, S. L., 7 May 2022, In: Lab on a chip. 22, 9, p. 1815-1828 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile33 Citations (Scopus)192 Downloads (Pure) -
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease Severity
Hendriks, J., Schasfoort, R., Koerselman, M., Dannenberg, M., Cornet, A. D., Beishuizen, A., van der Palen, J., Krabbe, J., Mulder, A. H. L. & Karperien, M., 13 Apr 2022, In: Frontiers in Immunology. 13, 867716.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile23 Citations (Scopus)115 Downloads (Pure) -
Injectable Cell-Laden Polysaccharide Hydrogels: In Vivo Evaluation of Cartilage Regeneration
Fu, Y., Both, S. K., Plass, J. R. M., Dijkstra, P. J., Zoetebier, B. & Karperien, M., Oct 2022, In: Polymers. 14, 20, 4292.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)158 Downloads (Pure) -
Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects
Zoetebier, B., Schmitz, T. C., Ito, K., Karperien, M., Tryfonidou, M. A. & Paez, J. I., 16 Jun 2022, In: Tissue Engineering - Part A. 28, 11-12, p. 478-499 22 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open AccessFile16 Citations (Scopus)406 Downloads (Pure) -
Intra-articular drug depots for controlled release of heavy chain only antibodies blocking joint inflammation
Koerselman, M., Warmink, K., Korthagen, N. M., van Midwoud, P. M., Verrips, T., Weinans, H. & Karperien, M., Apr 2022, In: Osteoarthritis and cartilage. 29, suppl. 1, p. S12-S13 2 p.Research output: Contribution to journal › Meeting Abstract › Academic
Open AccessFile62 Downloads (Pure) -
Joint-on-chip platforms: entering a new era of in vitro models for arthritis
Paggi, C. A., Moreira Teixeira, L., le Gac, S. & Karperien, M., Apr 2022, In: Nature reviews rheumatology. 18, p. 217-231 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile54 Citations (Scopus)370 Downloads (Pure) -
Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application
Hendriks, J., Schasfoort, R. B. M., Huskens, J., Saris, D. B. F. & Karperien, M., 1 Dec 2022, In: Analytical biochemistry. 658, 114918.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Citations (Scopus)136 Downloads (Pure) -
2021
An ECHO of cartilage: In silico prediction of combinatorial treatments to switch between transient and permanent cartilage phenotypes with ex vivo validation
Khurana, S., Schivo, S., Plass, J. R. M., Mersinis, N., Scholma, J., Kerkhofs, J., Zhong, L., van de Pol, J., Langerak, R., Geris, L., Karperien, M. & Post, J. N., 15 Nov 2021, In: Frontiers in bioengineering and biotechnology. 9, 21 p., 732917.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Citations (Scopus)127 Downloads (Pure) -
A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system
Paggi, C. A., Araújo da Cunha Gomes, N. M., Zuchowska, A., Karperien, M. & le Gac, S., 10 Oct 2021.Research output: Contribution to conference › Poster › Academic
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A synovial membrane-on-chip studying the development of rheumatoid arthritis in a triple culture system
Paggi, C. A., Araújo da Cunha Gomes, N. M., Zuchowska, A., Karperien, M. & le Gac, S., 10 Oct 2021, MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, p. 485-486 2 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
1 Citation (Scopus) -
Autophagy is involved in mesenchymal stem cell death in coculture with chondrocytes
Paggi, C. A., Dudakovic, A., Fu, Y., Garces, C. G., Hevesi, M., Galeano Garces, D., Dietz, A. B., van Wijnen, A. & Karperien, M., 1 Dec 2021, In: Cartilage. 13, 2_suppl, p. 969S-979SResearch output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)113 Downloads (Pure) -
Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform
van Dorp, T., Paggi, C. A., Slaats, R. H., Schwach, V., le Gac, S., Passier, R. & Karperien, M., 10 Oct 2021.Research output: Contribution to conference › Poster › Academic
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Cyclic exposure to compressive forces increases the differentiation efficiency of hipscs towards chondrocytes in a cartilage-on-chip platform
van Dorp, T., Paggi, C. A., Slaats, R. H., Schwach, V., le Gac, S., Passier, R. & Karperien, M., 10 Oct 2021, Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021. p. 495-496Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
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Engineering cartilage tissue by co-culturing of chondrocytes and mesenchymal stromal cells
Fu, Y., Paggi, C. A., Dudakovic, A., van Wijnen, A. J., Post, J. N. & Karperien, M., 2021, Osteoporosis and Osteoarthritis. van Wijnen, A. J. & Ganshina, M. S. (eds.). Humana Press, p. 53-70 18 p. (Methods in Molecular Biology; vol. 2221).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
2 Citations (Scopus) -
Engineering of optimized hydrogel formulations for cartilage repair
Fu, Y., Zoetebier, B., Both, S., Dijkstra, P. J. & Karperien, M., 10 May 2021, In: Polymers. 13, 9, 1526.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile18 Citations (Scopus)142 Downloads (Pure) -
High throughput surface plasmon resonance imaging method for clinical detection of presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection
Schasfoort, R. B. M., van Weperen, J., van Amsterdam, M., Parisot, J., Hendriks, J., Koerselman, M., Karperien, M., Mentink - Leusink, A., Bennink, M., Krabbe, H., Terstappen, L. W. M. M. & Mulder, A. H. L., 29 Jun 2021, In: MethodsX. 8, 101432.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile153 Downloads (Pure) -
Injectable hydrogels functionalized with antibody fragments as intra-articular cytokine sinks neutralizing pro-catabolic cytokines
Zhong, L., Koerselman, M., Karbaat, L., Kamperman, T., Leijten, J., Zoetebier, B. & Karperien, M., Apr 2021, In: Osteoarthritis and cartilage. 29, Suppl. 1, p. S50-S50 1 p.Research output: Contribution to journal › Meeting Abstract › Academic
6 Downloads (Pure) -
Investigating end-stage osteaorthitic cartilage and chondrosarcoma response to mechanical stimulation
Paggi, C. A., Porsul, I., Plass, J. R. M., Karperien, M. & le Gac, S., 10 Oct 2021, Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021. p. 429-430Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
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In vitro degradation profiles and in vivo biomaterial–tissue interactions of microwell array delivery devices
Hadavi, E., de Vries, R. H. W., Smink, A. M., de Haan, B., Leijten, J., Schwab, L. W., Karperien, M. H. B. J., de Vos, P., Dijkstra, P. J. & van Apeldoorn, A. A., 1 Jan 2021, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 109, 1, p. 117-127 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)129 Downloads (Pure) -
Mapping SOX9 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells
Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., 29 Nov 2021, bioRxiv.Research output: Working paper › Preprint › Academic
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Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection
Schasfoort, R. B. M., van Weperen, J., van Amsterdam, M., Parisot, J., Hendriks, J., Koerselman, M., Karperien, M., Mentink, A., Bennink, M., Krabbe, H., Terstappen, L. W. M. M. & Mulder, A. H. L., 1 Jul 2021, In: Biosensors & bioelectronics. 183, 113165.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile26 Citations (Scopus)165 Downloads (Pure) -
Protein adsorption enhances energy dissipation in networks of lysozyme amyloid fibrils
van Dalen, M. C. E., Vaneyck, J., Semerdzhiev, S. A., Karperien, M., Post, J. N. & Claessens, M. M. A. E., 22 Jun 2021, In: Langmuir. 37, 24, p. 7349–7355 7 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Citations (Scopus)163 Downloads (Pure) -
Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non-Cell-Adhesive Materials
Kamperman, T., Henke, S., Crispim, J. F., Willemen, N. G. A., Dijkstra, P. J., Lee, W., Offerhaus, H. L., Neubauer, M., Smink, A. M., de Vos, P., de Haan, B. J., Karperien, M., Ryon Shin, S. & Leijten, J., 21 Oct 2021, In: Advanced materials. 33, 42, 2102660.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile19 Citations (Scopus)105 Downloads (Pure) -
The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity
Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 1 Oct 2021, In: Cartilage. 12, 4, p. 496-504Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile16 Citations (Scopus)103 Downloads (Pure) -
2020
A High Cell-Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans
Skrzypek, K., Groot Nibbelink, M., Liefers-Visser, J., Smink, A. M., Stoimenou, E., Engelse, M. A., de Koning, E. J. P., Karperien, M., de Vos, P., van Apeldoorn, A. & Stamatialis, D., 1 Aug 2020, In: Macromolecular bioscience. 20, 8, 2000021.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Citations (Scopus)78 Downloads (Pure) -
Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications
Jooybar, E., Abdekhodaie, M. J., Karperien, M., Mousavi, A., Alvi, M. & Dijkstra, P. J., 1 Feb 2020, In: International journal of biological macromolecules. 144, p. 837-846 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Citations (Scopus)185 Downloads (Pure) -
Droplet microfluidics to engineer smart building blocks for modular tissue engineering
Willemen, N. G. A., Kamperman, T., Kelder, C., Koerselman, M., Crispim, J., Hendriks, J., Henke, S., de Peuter, X., Dijkstra, P., Karperien, M. & Leijten, J., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, p. 721-722 2 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review
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ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease
Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 1 Apr 2020, In: Cellular Signalling. 68, 109471.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Citations (Scopus)201 Downloads (Pure)