H.B.J. Karperien

prof.dr.

  • 5564 Citations
  • 40 h-Index
20072020

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2020

Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

Jooybar, E., Abdekhodaie, M. J., Karperien, M., Mousavi, A., Alvi, M. & Dijkstra, P. J., 1 Feb 2020, In : International journal of biological macromolecules. 144, p. 837-846 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
29 Downloads (Pure)

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 1 Apr 2020, In : Cellular Signalling. 68, 109471.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Downloads (Pure)

Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation

van Loo, B., Salehi, S. S., Henke, S., Shamloo, A., Kamperman, T., Karperien, M. & Leijten, J., Mar 2020, In : Materials Today Bio. 6, 100047.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Downloads (Pure)

Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells

Gluscevic, M., Paradise, C. R., Dudakovic, A., Karperien, M., Dietz, A. B., van Wijnen, A. J. & Deyle, D. R., 5 May 2020, In : Gene. 737, 7 p., 144437.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

Dudakovic, A., Samsonraj, R. M., Paradise, C. R., Galeano-Garces, C., Mol, M. O., Galeano-Garces, D., Zan, P., Galvan, M. L., Hevesi, M., Pichurin, O., Thaler, R., Begun, D. L., Kloen, P., Karperien, M., Larson, A. N., Westendorf, J. J., Cool, S. M. & van Wijnen, A. J., 5 Jun 2020, In : The Journal of biological chemistry. 295, 23, p. 7877-7893 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation

Ooi, H. W., Kocken, J. M. M., Morgan, F. L. C., Malheiro, A., Zoetebier, B., Karperien, M., Wieringa, P. A., Dijkstra, P. J., Moroni, L. & Baker, M. B., 8 Jun 2020, In : Biomacromolecules. 21, 6, p. 2208-2217 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Downloads (Pure)
2019

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells

Jooybar, E., Abdekhodaie, M. J., Alvi, M., Karperien, M. & Dijkstra, P. J., 1 Jan 2019, In : Acta biomaterialia. 83, p. 233-244 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
131 Downloads (Pure)
Open Access
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1 Citation (Scopus)
83 Downloads (Pure)

Defining the baseline transcriptional fingerprint of rabbit hamstring autograft

Hevesi, M., Paradise, C. R., Paggi, C. A., Galeano-Garces, C., Dudakovic, A., Karperien, M., Kakar, S., Hewett, T. E., Krych, A. J., van Wijnen, A. J. & Saris, D. B. F., 1 Jun 2019, In : Gene Reports. 15, 100363.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
10 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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52 Downloads (Pure)

In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load

Spitters, T. W. G. M., Stamatialis, D., Petit, A., De Leeuw, M. G. W. & Karperien, M., 6 Jun 2019, In : Assay and Drug Development Technologies. 17, 4, p. 191-200 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets

Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
1 Downloads (Pure)

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
3 Downloads (Pure)

Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers

Peng, H., Huang, X., Melle, A., Karperien, M. & Pich, A., 22 Mar 2019, In : Journal of colloid and interface science. 540, p. 612-622 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
57 Downloads (Pure)

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

An important step towards a prevascularized islet macroencapsulation device: Effect of micropatterned membranes on development of endothelial cell network

Skrzypek, K., Nibbelink, M. G., Karbaat, L. P., Karperien, M., van Apeldoorn, A. & Stamatialis, D., 1 Jul 2018, In : Journal of Materials Science: Materials in Medicine. 29, 7, 91.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
31 Downloads (Pure)

An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes

Groot Nibbelink, M., Skrzypek, K., Karbaat, L., Both, S., Plass, J., Klomphaar, B., van Lente, J., Henke, S., Karperien, M., Stamatialis, D. & van Apeldoorn, A., 1 Nov 2018, In : Journal of Materials Science: Materials in Medicine. 29, 11, 174.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
40 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
32 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
35 Downloads (Pure)

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

Dudakovic, A., Camilleri, E. T., Paradise, C. R., Samsonraj, R. M., Gluscevic, M., Paggi, C. A., Begun, D. L., Khani, F., Pichurin, O., Ahmed, F. S., Elsayed, R., Elsalanty, M., McGee-Lawrence, M. E., Karperien, M., Riester, S. M., Thaler, R., Westendorf, J. J. & van Wijnen, A. J., 17 Aug 2018, In : Journal of biological chemistry. 293, 33, p. 12894-12907 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
30 Downloads (Pure)

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2 Citations (Scopus)
53 Downloads (Pure)

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6

Cabanas-Danés, J., Landman, E., Huskens, J., Karperien, M. & Jonkheijm, P., 7 Aug 2018, In : Langmuir. 34, 31, p. 9298-9306 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
30 Downloads (Pure)

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials

Visser, C. W., Kamperman, T., Karbaat, L. P., Lohse, D. & Karperien, M., 1 Jan 2018, In : Science advances. 4, 1, eaao1175.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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36 Citations (Scopus)
82 Downloads (Pure)

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affectcartilage development

Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H-J., Karperien, M., Krych, A. J., Westendorf, J. J., Larson, A. N. & van Wijnen, A. J., 7 Dec 2018, In : Journal of biological chemistry. 293, p. 19001-19011 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
15 Downloads (Pure)

Molecular characterization of physis tissue by RNA sequencing

Paradise, C. R., Galeano-Garces, C., Galeano-Garces, D., Dudakovic, A., Milbrandt, T. A., Saris, D. B. F., Krych, A. J., Karperien, M., Ferguson, G. B., Evseenko, D., Riester, S. M., van Wijnen, A. J. & Noelle Larson, A., 20 Aug 2018, In : Gene. 668, p. 87-96 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging

Hendriks, J., Stojanovic, I., Schasfoort, R. B. M., Saris, D. B. F. & Karperien, M., 5 Jun 2018, In : Analytical chemistry. 90, 11, p. 6563-6571 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
27 Downloads (Pure)

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds

Huang, X., Hou, Y., Zhong, L., Huang, D., Qian, H., Karperien, M. & Chen, W., 8 Jan 2018, In : Biomacromolecules. 19, 1, p. 94-102 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Single-Cell Microgels: Technology, Challenges, and Applications

Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
124 Downloads (Pure)

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
57 Downloads (Pure)

Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture

Pleumeekers, M. M., Nimeskern, L., Koevoet, J. L. M., Karperien, M., Stok, K. S. & van Osch, G. J. V. M., 28 Feb 2018, In : PLoS ONE. 13, 2, e0190744.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
53 Downloads (Pure)
Open Access
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13 Citations (Scopus)
99 Downloads (Pure)
2017

Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles

Dijkstra, K., Hendriks, J., Karperien, M., Vonk, L. A. & Saris, D. B. F., 1 Sep 2017, In : Tissue engineering. Part C: Methods. 23, 9, p. 505-515 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
1 Downloads (Pure)

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
121 Downloads (Pure)

Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization

Marchioli, G., Zellner, L., Oliveira, C., Engelse, M., de Koning, E., Mano, J. F., Karperien, H. B. J., Apeldoorn, A. V. & Moroni, L., 1 Dec 2017, In : Journal of materials science. Materials in medicine. 28, 12, 195.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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12 Citations (Scopus)
55 Downloads (Pure)

Micro-fabricated scaffolds lead to efficient remission of diabetes in mice

Buitinga, M., Assen, F., Hanegraaf, M., Wieringa, P., Hilderink, J., Moroni, L., Truckenmüller, R., van Blitterswijk, C., Römer, G-W., Carlotti, F., de Koning, E., Karperien, M. & van Apeldoorn, A., Aug 2017, In : Biomaterials. 135, p. 10-22

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
96 Downloads (Pure)

Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue–Derived Human Mesenchymal Stromal Cells

Galeano-Garces, C., Camilleri, E. T., Riester, S. M., Dudakovic, A., Larson, D. R., Qu, W., Smith, J., Dietz, A. B., Im, H-J., Krych, A. J., Larson, A. N., Karperien, M. & van Wijnen, A. J., 1 Jul 2017, In : Cartilage. 8, 3, p. 283-299 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
112 Downloads (Pure)

Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets

Kamperman, T., Henke, S., Zoetebier, B., Ruiterkamp, N., Wang, R., Pouran, B., Weinans, H., Karperien, M. & Leijten, J., 2 May 2017, In : Journal of materials chemistry. B: materials for biology and medicine. 5, 25, p. 4835-4844 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Citations (Scopus)
86 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14 Citations (Scopus)
60 Downloads (Pure)

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Welting, T. J. M., Karperien, M. & Post, J. N., 17 Jul 2017, In : Biotarget. 2, 11, 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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26 Downloads (Pure)

O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models

Georgi, N., Landman, E. B. M., Klein, T. J., van Blitterswijk, C. A. & Karperien, M., 1 Mar 2017, In : Journal of tissue engineering and regenerative medicine. 11, 3, p. 724-732 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
49 Downloads (Pure)

Pancreatic islet macroencapsulation using microwell porous membranes

Skrzypek, K., Groot Nibbelink, M., Van Lente, J., Buitinga, M., Engelse, M. A., De Koning, E. J. P., Karperien, M., Van Apeldoorn, A. & Stamatialis, D., 1 Dec 2017, In : Scientific reports. 7, 1, 9186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
55 Downloads (Pure)

Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments

Kamperman, T., Henke, S. J., van den Berg, A., Shin, S. R., Tamayol, A., Khademhosseini, A., Karperien, H. B. J. & Leijten, J. C. H., 14 Dec 2017, In : Advanced healthcare materials. 6, 3, 9 p., 1600913.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L., 2017, In : Biochemical and biophysical research communications. 482, 2, p. 323-328 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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63 Citations (Scopus)
71 Downloads (Pure)
2016

A facile approach for thermal and reduction dual-responsive prodrug nanogels for intracellular doxorubicin delivery

Peng, H., Huang, X., Oppermann, A., Melle, A., Weger, L., Karperien, M., Wöll, D. & Pich, A., 2016, In : Journal of materials chemistry. B: materials for biology and medicine. 4, 47, p. 7572-7583 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

A microfluidic device with continuous ligand gradients in supported lipid bilayers to probe effects of ligand surface density and solution shear stress on pathogen adhesion

van Weerd, J., Sankaran, S., Roling, O., Sukas, S., Krabbenborg, S., Huskens, J., le Gac, S., Ravoo, B. J., Karperien, H. B. J. & Jonkheijm, P., 2016, In : Advanced materials interfaces. 3, 9, p. - 6 p., 1600055.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)

A Protocol to Enhance INS1E and MIN6 Functionality—The Use of Theophylline

Groot Nibbelink, M., Marchioli, G., Moroni, L., Karperien, H. B. J. & van Apeldoorn, A. A., 2016, In : International journal of molecular sciences. 17, 1532, p. - 9 p., 1532.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
57 Downloads (Pure)

Chondrocytes co-cultured with Stromal Vascular Fraction of adipose tissue present more intense chondrogenic characteristics than with Adipose Stem Cells

Wu, L., Prins, H-J., Leijten, J., Helder, M. N., Evseenko, D., Moroni, L., van Blitterswijk, C., Lin, Y. & Karperien, M., 6 Jan 2016, In : Tissue engineering. Part A. 22, 3-4, p. 336-348

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)