J.C.H. Leijten

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  • 1549 Citations
  • 23 h-Index
20082020

Research output per year

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Research Output

2020

Engineering 3D parallelized microfluidic droplet generators with equal flow profiles by computational fluid dynamics and stereolithographic printing

Kamperman, T., Teixeira, L. M., Salehi, S. S., Kerckhofs, G., Guyot, Y., Geven, M., Geris, L., Grijpma, D., Blanquer, S. & Leijten, J., 7 Feb 2020, In : Lab on a chip. 20, 3, p. 490-495 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation

van Loo, B., Salehi, S. S., Henke, S., Shamloo, A., Kamperman, T., Karperien, M. & Leijten, J., Mar 2020, In : Materials Today Bio. 6, 100047.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Downloads (Pure)
2019

3D Printed Cartilage-Like Tissue Constructs with Spatially Controlled Mechanical Properties

de Melo, B. A. G., Jodat, Y. A., Mehrotra, S., Calabrese, M. A., Kamperman, T., Mandal, B. B., Santana, M. H. A., Alsberg, E., Leijten, J. & Shin, S. R., 19 Dec 2019, In : Advanced functional materials. 29, 51, 1906330.

Research output: Contribution to journalArticleAcademicpeer-review

Bioionic Liquid Conjugation as Universal Approach to Engineer Hemostatic Bioadhesives

Krishnadoss, V., Melillo, A., Kanjilal, B., Hannah, T., Ellis, E., Kapetanakis, A., Hazelton, J., San Roman, J., Masoumi, A., Leijten, J. & Noshadi, I., 23 Oct 2019, In : ACS Applied Materials and Interfaces. 11, 42, p. 38373-38384 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets

Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)

Mimicking the Articular Joint with In Vitro Models

Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., Leijten, J., van Weeren, R. & Malda, J., 1 Oct 2019, In : Trends in biotechnology. 37, 10, p. 1063-1077 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Trujillo-de Santiago, G., Sharifi, R., Yue, K., Sani, E. S., Kashaf, S. S., Alvarez, M. M., Leijten, J., Khademhosseini, A., Dana, R. & Annabi, N., 1 Mar 2019, In : Biomaterials. 197, p. 345-367 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
6 Citations (Scopus)
15 Downloads (Pure)

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
3 Downloads (Pure)

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
41 Downloads (Pure)
2018

A cartilage-on-a-chip platform recapitulating joint motion

Paggi, C. A., Venzac, B., Leijten, J. & le Gac, S., 30 Oct 2018.

Research output: Contribution to conferencePoster

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
31 Downloads (Pure)

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
36 Downloads (Pure)

High-throughput approaches for screening and analysis of cell behaviors

Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., Brinegar, K., Ghaemmaghami, A. M., Alsberg, E. & Khademhosseini, A., 1 Jan 2018, In : Biomaterials. 153, p. 85-101 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
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17 Citations (Scopus)
9 Downloads (Pure)

Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions

Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Bal Öztürk, A., Rouwkema, J., Li, Y., Shin, S. R., Hajiali, H., Alsberg, E. & Khademhosseini, A., 25 Apr 2018, In : ACS applied materials & interfaces. 10, 16, p. 13293-13303 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

MICROFLUIDIC DEVICE FOR MECHANICALLY STIMULATING A MATERIAL

le Gac, S., J., L., Paggi, C. A. & Venzac, B., 2018, (Submitted) Patent No. EP18202998, 26 Oct 2018

Research output: Patent

Mimicking articular motion in a cartilage-on-a-chip model

Paggi, C. A., Venzac, B., Leijten, J. & le Gac, S., 11 Nov 2018.

Research output: Contribution to conferencePoster

Single-Cell Microgels: Technology, Challenges, and Applications

Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14 Citations (Scopus)
92 Downloads (Pure)
Open Access
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10 Citations (Scopus)
82 Downloads (Pure)
2017

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., Dokmeci, M. R., Nissan, X., Ferreira, L. & Khademhosseini, A., 17 Feb 2017, In : Small. 13, 15, 13 p., 1603737.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
20 Citations (Scopus)
100 Downloads (Pure)

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
File
87 Downloads (Pure)

Concise Review: Organ Engineering: Design, Technology, and Integration

Kaushik, G., Leijten, J. C. H. & Khademhosseini, A., Jan 2017, In : Stem cells. 35, 1, p. 51-60 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs

Zhu, K., Shin, S. R., van Kempen, T., Li, Y-C., Ponraj, V., Nasajpour, A., Mandla, S., Hu, N., Liu, X., Leijten, J. C. H., Lin, Y-D., Hussain, M. A., Zhang, Y. S., Tamayol, A. & Khademhosseini, A., 24 Mar 2017, In : Advanced functional materials. 27, 12, 1605352.

Research output: Contribution to journalArticleAcademicpeer-review

77 Citations (Scopus)
1 Downloads (Pure)

Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells

Bolander, J., Ji, W., Leijten, J., Moreira Teixeira, L., Bloemen, V., Lambrechts, D., Chaklader, M. & Luyten, F. P., 14 Mar 2017, In : Stem cell reports. 8, 3, p. 758–772

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
43 Downloads (Pure)

Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

Cha, B-H., Ryon Shin, S., Leijten, J., Li, Y-C., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., Ghaemmaghami, A. M. & Khademhosseini, A., 8 Nov 2017, In : Advanced healthcare materials. 6, 21, 1700289.

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Microfluidically generated single cell microgels for multi-scale tissue engineering

Leijten, J., 2017, p. 1.

Research output: Contribution to conferenceAbstract

Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets

Kamperman, T., Henke, S., Zoetebier, B., Ruiterkamp, N., Wang, R., Pouran, B., Weinans, H., Karperien, M. & Leijten, J., 2 May 2017, In : Journal of materials chemistry. B: materials for biology and medicine. 5, 25, p. 4835-4844 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
79 Downloads (Pure)

Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

Nasajpour, A., Mandla, S., Shree, S., Mostafavi, E., Sharifi, R., Khalilpour, A., Saghazadeh, S., Hassan, S., Mitchell, M. J., Leijten, J., Hou, X., Moshaverinia, A., Annabi, N., Adelung, R., Kumar Mishra, Y., Ryon Shin, S., Tamayol, A. & Khademhosseini, A., 11 Oct 2017, In : Nano letters. 17, 10, p. 6235-6240 6 p.

Research output: Contribution to journalLetterAcademicpeer-review

39 Citations (Scopus)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
51 Downloads (Pure)

Oxygen-Generating Photo-Cross-Linkable Hydrogels Support Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis

Alemdar, N., Leijten, J. C. H., Camci-Unal, G., Hjortnaes, J., Ribas, J., Paul, A., Mostafalu, P., Gaharwar, A. K., Qiu, Y., Sonkusale, S., Liao, R. & Khademhosseini, A., 11 Sep 2017, In : ACS biomaterials science & engineering. 3, 9, p. 1964-1971

Research output: Contribution to journalArticleAcademic

17 Citations (Scopus)

Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments

Kamperman, T., Henke, S. J., van den Berg, A., Shin, S. R., Tamayol, A., Khademhosseini, A., Karperien, H. B. J. & Leijten, J. C. H., 14 Dec 2017, In : Advanced healthcare materials. 6, 3, 9 p., 1600913.

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Spatially and temporally controlled hydrogels for tissue engineering

J., L., Seo, J., Yue, K., Trujillo-de Santiago, G., Tamayol, A., Ruiz-Esparza, G. U., Ryon Shin, S., Sharifi, R., Noshadi, I., Moises Alvarez, M., Shrike Zhang, Y. & Khademhosseini, A., 1 Sep 2017, In : Materials Science and Engineering R: Reports. 119, p. 1-35 35 p.

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives

Yue, K., Li, X., Schrobback, K., Sheikhi, A., Annabi, N., Leijten, J., Zhang, W., Zhang, Y. S., Hutmacher, D. W., Klein, T. J. & Khademhosseini, A., Sep 2017, In : Biomaterials. 139, p. 163-171

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration

Fu, Y., Karbaat, L., Wu, L., Leijten, J., Both, S. K. & Karperien, M., 1 Dec 2017, In : Tissue engineering. Part B: Reviews. 23, 6, p. 515-528 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

59 Citations (Scopus)
2016

Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration

Leijten, J. C. H., Rouwkema, J., Zhang, Y. S., Nasajpour, A., Dokmeci, M. R. & Khademhosseini, A., 2016, In : Small. 12, 16, p. 2130-2145 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
43 Downloads (Pure)

Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions

Leijten, J., Moreira Teixeira, L. S., Bolander, J., Ji, W., Vanspauwen, B., Lammertyn, J., Schrooten, J. & Luyten, F. P., 3 Nov 2016, In : Scientific reports. 6, 36011, 36011.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Citations (Scopus)
57 Downloads (Pure)

Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

Ribas, J., Sadeghi, H., Manbachi, A., Leijten, J. C. H., Brinegar, K., Zhang, Y. S., Ferreira, L. & Khademhosseini, A., 2016, In : Applied in vitro toxicology. 2, 2, p. 82-96

Research output: Contribution to journalArticleAcademicpeer-review

Chondrocytes co-cultured with Stromal Vascular Fraction of adipose tissue present more intense chondrogenic characteristics than with Adipose Stem Cells

Wu, L., Prins, H-J., Leijten, J., Helder, M. N., Evseenko, D., Moroni, L., van Blitterswijk, C., Lin, Y. & Karperien, M., 6 Jan 2016, In : Tissue engineering. Part A. 22, 3-4, p. 336-348

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

DKK1AND FRZB are necessary for chondrocyte (RE) differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells

Zhong, L., Huang, X., Rodrigues, E., Leijten, J., Verrips, T., El Khattabi, M., Karperien, M. & Post, J., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S142 229.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
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56 Downloads (Pure)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
65 Downloads (Pure)

Engineering 3D Single Stem Cell Microniches with Dynamically Tunable Stiffness

Kamperman, T., Henke, S. J., Neubauer, M., Fery, A., Karperien, H. B. J. & Leijten, J. C. H., 22 Mar 2016, p. -.

Research output: Contribution to conferencePoster

Engineering 3D Single Stem Cell Microniches with Dynamically Tunable Stiffness

Kamperman, T., Henke, S. J., Neubauer, M., Fery, A., Leijten, J. C. H. & Karperien, H. B. J., 28 Jun 2016, p. -.

Research output: Contribution to conferencePoster

Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels

Henke, S. J., Leijten, J. C. H., Kemna, E., Neubauer, M., Neubauer, M., Fery, A., Fery, A., van den Berg, A., van Apeldoorn, A. A. & Karperien, H. B. J., Oct 2016, In : Macromolecular bioscience. 16, 10, p. 1524-1532 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2 Downloads (Pure)

From Nano to Macro: Multiscale Materials for Improved Stem Cell Culturing and Analysis

Leijten, J. C. H. & Khademhosseini, A., 7 Jan 2016, In : Cell stem cell. 18, 1, p. 20-24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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23 Citations (Scopus)
38 Downloads (Pure)

Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

Masoudi, E. A., Ribas, J., Kaushik, G., Leijten, J. C. H. & Khademhosseini, A., 13 Feb 2016, In : Current stem cell reports. 2, 1, p. 33-42 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

The matrix reloaded: the evolution of regenerative hydrogels

Jabbari, E., Leijten, J. C. H., Xu, Q. & Khademhosseini, A., 2016, In : Materials today. 19, 4, p. 190-196 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
66 Downloads (Pure)