J.C.H. Leijten

dr.

  • 1549 Citations
  • 23 h-Index
20082020

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2020

Engineering 3D parallelized microfluidic droplet generators with equal flow profiles by computational fluid dynamics and stereolithographic printing

Kamperman, T., Teixeira, L. M., Salehi, S. S., Kerckhofs, G., Guyot, Y., Geven, M., Geris, L., Grijpma, D., Blanquer, S. & Leijten, J., 7 Feb 2020, In : Lab on a chip. 20, 3, p. 490-495 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation

van Loo, B., Salehi, S. S., Henke, S., Shamloo, A., Kamperman, T., Karperien, M. & Leijten, J., Mar 2020, In : Materials Today Bio. 6, 100047.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Downloads (Pure)
2019

3D Printed Cartilage-Like Tissue Constructs with Spatially Controlled Mechanical Properties

de Melo, B. A. G., Jodat, Y. A., Mehrotra, S., Calabrese, M. A., Kamperman, T., Mandal, B. B., Santana, M. H. A., Alsberg, E., Leijten, J. & Shin, S. R., 19 Dec 2019, In : Advanced functional materials. 29, 51, 1906330.

Research output: Contribution to journalArticleAcademicpeer-review

Bioionic Liquid Conjugation as Universal Approach to Engineer Hemostatic Bioadhesives

Krishnadoss, V., Melillo, A., Kanjilal, B., Hannah, T., Ellis, E., Kapetanakis, A., Hazelton, J., San Roman, J., Masoumi, A., Leijten, J. & Noshadi, I., 23 Oct 2019, In : ACS Applied Materials and Interfaces. 11, 42, p. 38373-38384 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Microwell scaffolds using collagen-IV and laminin-111 lead to improved insulin secretion of human islets

Hadavi, E., Leijten, J., Engelse, M., De Koning, E., Jonkheijm, P., Karperien, M. & Van Apeldoorn, A., 1 Feb 2019, In : Tissue Engineering - Part C: Methods. 25, 2, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Downloads (Pure)

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Kamperman, T., Van Loo, B., Gurian, M., Henke, S., Karperien, M. & Leijten, J., 7 Jun 2019, In : Lab on a chip. 19, 11, p. 1977-1984 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
3 Downloads (Pure)

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

Kamperman, T., Koerselman, M., Kelder, C., Hendriks, J., Crispim, J. F., de Peuter, X., Dijkstra, P. J., Karperien, M. & Leijten, J., 25 Sep 2019, In : Nature communications. 10, 1, 11 p., 4347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
41 Downloads (Pure)
2018

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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6 Citations (Scopus)
31 Downloads (Pure)

Fibronectin and Collagen IV Microcontact Printing Improves Insulin Secretion by INS1E Cells

Hadavi, E., Leijten, J., Brinkmann, J., Jonkheijm, P., Karperien, M. & van Apeldoorn, A., 15 Nov 2018, In : Tissue engineering. Part C, Methods. 24, 11, p. 628-636 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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1 Citation (Scopus)
36 Downloads (Pure)

Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions

Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Bal Öztürk, A., Rouwkema, J., Li, Y., Shin, S. R., Hajiali, H., Alsberg, E. & Khademhosseini, A., 25 Apr 2018, In : ACS applied materials & interfaces. 10, 16, p. 13293-13303 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Single-Cell Microgels: Technology, Challenges, and Applications

Kamperman, T., Karperien, M., Le Gac, S. & Leijten, J., Aug 2018, In : Trends in biotechnology. 36, 8, p. 850-865 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14 Citations (Scopus)
92 Downloads (Pure)
Open Access
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10 Citations (Scopus)
82 Downloads (Pure)
2017

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., Dokmeci, M. R., Nissan, X., Ferreira, L. & Khademhosseini, A., 17 Feb 2017, In : Small. 13, 15, 13 p., 1603737.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

Kamperman, T., Henke, S., Visser, C. W., Karperien, M. & Leijten, J., 13 Jun 2017, In : Small. 13, 22, 1603711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
100 Downloads (Pure)

Concise Review: Organ Engineering: Design, Technology, and Integration

Kaushik, G., Leijten, J. C. H. & Khademhosseini, A., Jan 2017, In : Stem cells. 35, 1, p. 51-60 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs

Zhu, K., Shin, S. R., van Kempen, T., Li, Y-C., Ponraj, V., Nasajpour, A., Mandla, S., Hu, N., Liu, X., Leijten, J. C. H., Lin, Y-D., Hussain, M. A., Zhang, Y. S., Tamayol, A. & Khademhosseini, A., 24 Mar 2017, In : Advanced functional materials. 27, 12, 1605352.

Research output: Contribution to journalArticleAcademicpeer-review

77 Citations (Scopus)
1 Downloads (Pure)

Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells

Bolander, J., Ji, W., Leijten, J., Moreira Teixeira, L., Bloemen, V., Lambrechts, D., Chaklader, M. & Luyten, F. P., 14 Mar 2017, In : Stem cell reports. 8, 3, p. 758–772

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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16 Citations (Scopus)
43 Downloads (Pure)

Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

Cha, B-H., Ryon Shin, S., Leijten, J., Li, Y-C., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., Ghaemmaghami, A. M. & Khademhosseini, A., 8 Nov 2017, In : Advanced healthcare materials. 6, 21, 1700289.

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets

Kamperman, T., Henke, S., Zoetebier, B., Ruiterkamp, N., Wang, R., Pouran, B., Weinans, H., Karperien, M. & Leijten, J., 2 May 2017, In : Journal of materials chemistry. B: materials for biology and medicine. 5, 25, p. 4835-4844 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
79 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
51 Downloads (Pure)

Oxygen-Generating Photo-Cross-Linkable Hydrogels Support Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis

Alemdar, N., Leijten, J. C. H., Camci-Unal, G., Hjortnaes, J., Ribas, J., Paul, A., Mostafalu, P., Gaharwar, A. K., Qiu, Y., Sonkusale, S., Liao, R. & Khademhosseini, A., 11 Sep 2017, In : ACS biomaterials science & engineering. 3, 9, p. 1964-1971

Research output: Contribution to journalArticleAcademic

17 Citations (Scopus)

Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macrenvironments

Kamperman, T., Henke, S. J., van den Berg, A., Shin, S. R., Tamayol, A., Khademhosseini, A., Karperien, H. B. J. & Leijten, J. C. H., 14 Dec 2017, In : Advanced healthcare materials. 6, 3, 9 p., 1600913.

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Spatially and temporally controlled hydrogels for tissue engineering

J., L., Seo, J., Yue, K., Trujillo-de Santiago, G., Tamayol, A., Ruiz-Esparza, G. U., Ryon Shin, S., Sharifi, R., Noshadi, I., Moises Alvarez, M., Shrike Zhang, Y. & Khademhosseini, A., 1 Sep 2017, In : Materials Science and Engineering R: Reports. 119, p. 1-35 35 p.

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives

Yue, K., Li, X., Schrobback, K., Sheikhi, A., Annabi, N., Leijten, J., Zhang, W., Zhang, Y. S., Hutmacher, D. W., Klein, T. J. & Khademhosseini, A., Sep 2017, In : Biomaterials. 139, p. 163-171

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)
2016

Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration

Leijten, J. C. H., Rouwkema, J., Zhang, Y. S., Nasajpour, A., Dokmeci, M. R. & Khademhosseini, A., 2016, In : Small. 12, 16, p. 2130-2145 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
43 Downloads (Pure)

Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions

Leijten, J., Moreira Teixeira, L. S., Bolander, J., Ji, W., Vanspauwen, B., Lammertyn, J., Schrooten, J. & Luyten, F. P., 3 Nov 2016, In : Scientific reports. 6, 36011, 36011.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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9 Citations (Scopus)
57 Downloads (Pure)

Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development

Ribas, J., Sadeghi, H., Manbachi, A., Leijten, J. C. H., Brinegar, K., Zhang, Y. S., Ferreira, L. & Khademhosseini, A., 2016, In : Applied in vitro toxicology. 2, 2, p. 82-96

Research output: Contribution to journalArticleAcademicpeer-review

Chondrocytes co-cultured with Stromal Vascular Fraction of adipose tissue present more intense chondrogenic characteristics than with Adipose Stem Cells

Wu, L., Prins, H-J., Leijten, J., Helder, M. N., Evseenko, D., Moroni, L., van Blitterswijk, C., Lin, Y. & Karperien, M., 6 Jan 2016, In : Tissue engineering. Part A. 22, 3-4, p. 336-348

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
65 Downloads (Pure)

Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels

Henke, S. J., Leijten, J. C. H., Kemna, E., Neubauer, M., Neubauer, M., Fery, A., Fery, A., van den Berg, A., van Apeldoorn, A. A. & Karperien, H. B. J., Oct 2016, In : Macromolecular bioscience. 16, 10, p. 1524-1532 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2 Downloads (Pure)

From Nano to Macro: Multiscale Materials for Improved Stem Cell Culturing and Analysis

Leijten, J. C. H. & Khademhosseini, A., 7 Jan 2016, In : Cell stem cell. 18, 1, p. 20-24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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23 Citations (Scopus)
38 Downloads (Pure)

Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

Masoudi, E. A., Ribas, J., Kaushik, G., Leijten, J. C. H. & Khademhosseini, A., 13 Feb 2016, In : Current stem cell reports. 2, 1, p. 33-42 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

The matrix reloaded: the evolution of regenerative hydrogels

Jabbari, E., Leijten, J. C. H., Xu, Q. & Khademhosseini, A., 2016, In : Materials today. 19, 4, p. 190-196 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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20 Citations (Scopus)
66 Downloads (Pure)
2015

Optimizing cell viability in droplet-based cell deposition

Hendriks, J., Visser, C. W., Henke, S. J., Leijten, J. C. H., Saris, D. B. F., Sun, C., Lohse, D. & Karperien, H. B. J., 2015, In : Scientific reports. 5, 10 p., 11304.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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42 Citations (Scopus)
43 Downloads (Pure)
2014

Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells

Portalska, K. K., Moreira Teixeira, L., Leijten, J. C. H., Jin, R., van Blitterswijk, C., de Boer, J. & Karperien, H. B. J., 26 Sep 2014, In : Tissue engineering. Part A. 20, 3-4, p. 819-829 35 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Leijten, J., Georgi, N., Moreira Teixeira, L., van Blitterswijk, C., Post, J. N. & Karperien, M., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13954-13959

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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65 Citations (Scopus)
45 Downloads (Pure)

Producing artificial chondrons for improved cartilage repair

Kamperman, T., Leijten, J. C. H., Henke, S. J. & Karperien, H. B. J., 2014, In : Osteoarthritis and cartilage. 22, Suppl., p. S485-S486

Research output: Contribution to journalArticleAcademicpeer-review

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55 Downloads (Pure)
2013

A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering

Spitters, T., Leijten, J. C. H., Deus, F. D., Costa, I. B. F., van Apeldoorn, A. A., van Blitterswijk, C. & Karperien, H. B. J., 15 Feb 2013, In : Tissue engineering. Part C: Methods. 19, 10, p. 774-783

Research output: Contribution to journalArticleAcademicpeer-review

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21 Citations (Scopus)
115 Downloads (Pure)

Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures

Leijten, J. C. H., Georgi, N., Wu, L., van Blitterswijk, C. & Karperien, H. B. J., 30 Jul 2013, In : Tissue engineering. Part B: Reviews. 19, 1, p. 31-40

Research output: Contribution to journalArticleAcademicpeer-review

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46 Citations (Scopus)
97 Downloads (Pure)

Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture

Wu, L., Leijten, J. C. H., van Blitterswijk, C. & Karperien, H. B. J., 2013, In : Stem cells and development. 22, 17, p. 2356-2367

Research output: Contribution to journalArticleAcademicpeer-review

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

Ma, B., Leijten, J. C. H., Wu, L., Kip, M. M. A., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 30 Jan 2013, In : Osteoarthritis and cartilage. 21, 4, p. 599-603 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

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90 Citations (Scopus)
51 Downloads (Pure)

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis associated factors

Leijten, J. C. H., Bos, S. D., Landman, E., Georgi, N., Jahr, H., Meulenbelt, I., Post, J. N., van Blitterswijk, C. & Karperien, H. B. J., 19 Sep 2013, In : Arthritis research & therapy. 15, 5, p. 1-11 R126.

Research output: Contribution to journalArticleAcademicpeer-review

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34 Citations (Scopus)
63 Downloads (Pure)

In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal.

Higuera, G. A., Hendriks, J. A. A., van Dalum, J., Wu, L., Schotel, R., Moreira-Teixeira, L., van den Doel, M., Leijten, J. C. H., Riesle, J., Karperien, M., van Blitterswijk, C. & Moroni, L., 2013, In : Integrative biology. 2013, 6, p. 889-898

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
45 Downloads (Pure)
2012

Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage

van Gool, S. A., Emons, J. A. M., Leijten, J. C. H., Decker, E., Sticht, C., van Houwelingen, J. C., Goeman, J. J., Kleijburg, C., Scherjon, S., Gretz, N., Wit, J. M., Rappold, G., Post, J. N. & Karperien, H. B. J., 2012, In : PLoS ONE. 7, 11, p. 1-11 11 p., e44561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
56 Downloads (Pure)

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

Leijten, J. C. H., Emons, J., Sticht, C., van Gool, S., Decker, E., Uitterlinden, A., Rappold, G., Hofman, A., Rivadeneira, F., Scherjon, S., Wit, J. M., van Meurs, J., van Blitterswijk, C. & Karperien, H. B. J., 2012, In : Arthritis & rheumatism. 64, 10, p. 3302-3312

Research output: Contribution to journalArticleAcademicpeer-review

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107 Downloads (Pure)

High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo

Moreira Teixeira, L., Leijten, J. C. H., Sobral, J., Jin, R., van Apeldoorn, A. A., Feijen, J., van Blitterswijk, C., Dijkstra, P. J. & Karperien, H. B. J., 2012, In : European cells & materials. 23, p. 387-399

Research output: Contribution to journalArticleAcademicpeer-review

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59 Citations (Scopus)
149 Downloads (Pure)

Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae

Leijten, J. C. H., Moreira Teixeira, L., Landman, E., van Blitterswijk, C. & Karperien, H. B. J., 2012, In : PLoS ONE. 7, 11, p. 1-7 7 p., e49896.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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30 Citations (Scopus)
55 Downloads (Pure)

Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

Periyasamy, P. C., Leijten, J. C. H., Dijkstra, P. J., Karperien, H. B. J. & Post, J. N., 2012, In : Journal of nanomaterials. 2012, 673968, p. - 13 p., 673968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
114 Downloads (Pure)