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Research Output 2003 2019

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Article
2019
4 Downloads (Pure)

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates

Deegan, A. J., Hendrikson, W. J., El Haj, A. J., Yang, Y. & Rouwkema, J., 1 Jun 2019, In : Biomedical Journal. 42, 3, p. 166-177 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Endothelial Cells
Suspensions
Bone and Bones
Transplants
Culture Techniques
2018
1 Downloads (Pure)

Glaucoma-on-a-chip: An in vitro model for glaucoma drug discovery based on mimicking the mechanical stress of high eye pressure

Gorgels, T. G. M. F., Vroemen, P. A. M. M., Sinha, R., Rouwkema, J., Moroni, L., de Boer, J. & Webers, C. A. B., Mar 2018, In : Acta Ophthalmologica. 96, p. 19-19

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three Dimensions

Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Bal Öztürk, A., Rouwkema, J., Li, Y., Shin, S. R., Hajiali, H., Alsberg, E. & Khademhosseini, A., 25 Apr 2018, In : ACS applied materials & interfaces. 10, 16, p. 13293-13303 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bioreactors
Screening
Hydrogels
Stem cells
Hydrogel
2 Citations (Scopus)
Open Access
File
Glutaral
Carbon Dioxide
Surgery
Carbon dioxide
Mechanical properties
2017
8 Citations (Scopus)

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., Dokmeci, M. R., Nissan, X., Ferreira, L. & Khademhosseini, A., 17 Feb 2017, In : Small. 13, 15, 13 p., 1603737.

Research output: Contribution to journalArticleAcademicpeer-review

Progeria
Vascular Diseases
Aging of materials
Inflammation
Drug Discovery
24 Citations (Scopus)
48 Downloads (Pure)

Engineering Photocrosslinkable Bicomponent Hydrogel Constructs for Creating 3D Vascularized Bone

Kazemzadeh-Narbat, M., Rouwkema, J., Annabi, N., Cheng, H., Ghaderi, M., Cha, B-H., Aparnathi, M., Khalilpour, A., Byambaa, B., Jabbari, E., Tamayol, A. & Khademhosseini, A., 27 Feb 2017, In : Advanced healthcare materials. 6, 10, 1601122.

Research output: Contribution to journalArticleAcademicpeer-review

File
Hydrogel
Hydrogels
Bone
Osteogenesis
Bone and Bones
12 Citations (Scopus)
40 Downloads (Pure)

Influence of Additive Manufactured Scaffold Architecture on the Distribution of Surface Strains and Fluid Flow Shear Stresses and Expected Osteochondral Cell Differentiation

Hendrikson, W. J., Deegan, A., Yang, Y., van Blitterswijk, C., Verdonschot, N. J. J., Moroni, L. & Rouwkema, J., 10 Feb 2017, In : Frontiers in bioengineering and biotechnology. 5, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
22 Citations (Scopus)

Towards 4D Printed Scaffolds for Tissue Engineering: Exploiting 3D Shape Memory Polymers to Deliver Time-Controlled Stimulus on Cultured Cells

Hendrikson, W. J., Rouwkema, J., Clementi, F., van Blitterswijk, C., Farè, S. & Moroni, L., 2 Aug 2017, In : Biofabrication. 9, 3, 031001.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Engineering
Scaffolds (biology)
Shape memory effect
Tissue engineering
Scaffolds
2016
28 Citations (Scopus)

Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration

Leijten, J. C. H., Rouwkema, J., Zhang, Y. S., Nasajpour, A., Dokmeci, M. R. & Khademhosseini, A., 2016, In : Small. 12, 16, p. 2130-2145 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Microtechnology
Nanotechnology
Tissue Engineering
Tissue engineering
Cellular Microenvironment
4 Citations (Scopus)
1 Downloads (Pure)

Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration

Hendrikson, W. J., Zeng, X., Rouwkema, J., van Blitterswijk, C., van der Heide, E. & Moroni, L., 2016, In : Advanced healthcare materials. 5, 2, p. 232-243

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Scaffolds
Ethylene Oxide
Tissue regeneration
Polycaprolactone
Lactic acid
13 Citations (Scopus)

Directed Assembly and Development of Material-Free Tissues with Complex Architectures

Vrij, E., Rouwkema, J., LaPointe, V., van Blitterswijk, C., Truckenmüller, R. K. & Rivron, N. C., 2016, In : Advanced materials. 28, 21, p. 4032-4039 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
16 Downloads (Pure)

Endothelial cell alignment as a result of anisotropic strain and flow induced shear stress combinations

Sinha, R., le Gac, S., Verdonschot, N. J. J., van den Berg, A., Koopman, H. F. J. M. & Rouwkema, J., 12 Jul 2016, In : Scientific reports. 6, 12 p., 29510.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
shear stress
endothelial cells
in vitro studies
blood flow
cells
93 Citations (Scopus)

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., Vrana, N. E. & Khademhosseini, A., 2016, In : Trends in biotechnology. 34, 6, p. 470-482 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biocompatible Materials
Biomaterials
Immunomodulation
Tissue Engineering
Tissue engineering
17 Citations (Scopus)
22 Downloads (Pure)

Increased cell seeding efficiency in bioplotted three-dimensional PEOT/PBT scaffolds

Leferink, A. M., Hendrikson, W. J., Rouwkema, J., Karperien, H. B. J., van Blitterswijk, C. & Moroni, L., 1 Aug 2016, In : Journal of tissue engineering and regenerative medicine. 10, 8, p. 679-689 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Scaffolds
Cell Count
Biocompatible Materials
Scaffolds (biology)
Stem cells
5 Citations (Scopus)
2 Downloads (Pure)

Mold-based application of laser-induced periodic surface structures (LIPPS) on biomaterials for nanoscale patterning

Hendrikson, W. J., Masman-Bakker, W., van Bochove, B., Skolski, J. Z. P., Eichstädt, J., Koopman, H. F. J. M., van Blitterswijk, C., Grijpma, D. W., Römer, G. R. B. E., Moroni, L. & Rouwkema, J., 3 Sep 2016, In : Macromolecular bioscience. 16, 1, p. 43-49 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biocompatible Materials
Biomaterials
Surface structure
Lasers
Fungi
136 Citations (Scopus)

Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

Rouwkema, J. & Khademhosseini, A., 2016, In : Trends in biotechnology. 34, 9, p. 733-745 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Engineering
Tissue engineering
Nutrients
Blood Vessels
Tissue
2015
17 Citations (Scopus)

A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells

Sinha, R., le Gac, S., Verdonschot, N. J. J., van den Berg, A., Koopman, H. F. J. M. & Rouwkema, J., 31 Oct 2015, In : Lab on a chip. 15, 2, p. 429-439 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Shear stress
Flow of fluids
Throughput
Equipment and Supplies
Myoblasts
12 Citations (Scopus)
24 Downloads (Pure)

Influence of PCL molecular weight on mesenchymal stromal cell differentiation

Hendrikson, W. J., Rouwkema, J., van Blitterswijk, C. & Moroni, L., 2015, In : RSC advances. 5, p. 54510-54516 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polycaprolactone
Scaffolds
Molecular weight
Tissue engineering
Mechanical properties
13 Citations (Scopus)

Modeling mechanical signals on the surface of µCT and CAD based rapid prototype scaffold models to predict (early stage) tissue development

Hendrikson, W. J., van Blitterswijk, C., Verdonschot, N. J. J., Moroni, L. & Rouwkema, J., 13 May 2014, In : Biotechnology and bioengineering. 111, 9, p. 1864-1875 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue Engineering
Scaffolds
Cell Differentiation
Computer aided design
Biocompatible Materials
2013
364 Citations (Scopus)

Spheroid culture as a tool for creating 3D complex tissues

Fennema, E. M., Rivron, N. C., Rouwkema, J., van Blitterswijk, C. & de Boer, J., 2013, In : Trends in biotechnology. 31, 2, p. 108-115 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cell culture
Cell Culture Techniques
Tissue
Extracellular Matrix
Screening
2012
44 Citations (Scopus)
43 Downloads (Pure)

Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

Rivron, N. C., Raiss, C. C., Liu, J., Nandakumar, A., Sticht, C., Gretz, N., Truckenmüller, R., Rouwkema, J. & van Blitterswijk, C., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 12, p. 4413-4418 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Osteogenesis
Blood Vessels
Bone and Bones
Bony Callus
Tissue Engineering
73 Citations (Scopus)
41 Downloads (Pure)

Tissue deformation spatially modulates VEGF signaling and angiogenesis

Rivron, N. C., Vrij, E. J., Rouwkema, J., le Gac, S., van den Berg, A., Truckenmüller, R. K. & van Blitterswijk, C. A., 1 May 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 18, p. 6886-6891 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Vascular Endothelial Growth Factor A
Blood Vessels
Vascular Endothelial Growth Factor Receptor-2
Endothelial Cells
Cell Proliferation
2011
33 Citations (Scopus)

In vitro platforms for tissue engineering: implications for basic research and clinical translation.

Rouwkema, J., Gibbs, S., Lutolf, M. P., Martin, I., Vunjak-Novakovic, G. & Malda, J., 2011, In : Journal of tissue engineering and regenerative medicine. 5, 8, p. e164-e167 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010

Materiomics: Dealing with complexity in tissue engineering

van Blitterswijk, C. A., Stamatialis, D., Unadkat, H., Papenburg, B., Rouwkema, J., Truckenmuller, R., van Apeldoorn, A., Wessling, M. & de Boer, J., 1 Jan 2010, In : European Cells and Materials. 20, SUPPL. 1, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Supply of nutrients to cells in engineered tissues

Rouwkema, J., Koopman, H. F. J. M., van Blitterswijk, C., Dhert, W. J. A. & Malda, J., 2010, In : Biotechnology & genetic engineering reviews. 26, p. 163-178 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009
77 Citations (Scopus)

The use of endothelial progenitor cells for prevascularized bone tissue engineering

Rouwkema, J., Westerweel, P. E., de Boer, J., Verhaar, M. C. & van Blitterswijk, C., 2009, In : Tissue engineering. Part A. 15, 8, p. 2015-2027 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

93 Citations (Scopus)

Tissue assembly and organization: Developmental mechanisms in microfabricated tissues

Rivron, N. C., Rouwkema, J., Truckenmüller, R., Karperien, M., de Boer, J. & van Blitterswijk, C., 2009, In : Biomaterials. 30, 28, p. 4851-4858 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tissue
Morphogenesis
Cues
Microtechnology
Microfabrication
2008
41 Citations (Scopus)

Analysis of the Dynamics of Bone Formation, Effect of Cell Seeding Density, and Potential of Allogeneic Cells in Cell-Based Bone Tissue Engineering in Goats.

Kruyt, M. C., de Bruijn, J. D., Rouwkema, J., van Blitterswijk, C., Oner, C., Verbout, A. & Dhert, W., 2008, In : Tissue engineering. Part A. 14, 6, p. 1081-1088 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Crossing frontiers in biomaterials and regenerative medicine

Malda, J., Rouwkema, J., Leeuwenburgh, S. C. G., Dhert, W. J. A. & Kirkpatrick, C. J., 2008, In : Regenerative medicine. 3, 5, p. 765-768 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

118 Citations (Scopus)
80 Downloads (Pure)

Engineering vascularised tissues in vitro

Rivron, N. C., Rivron, N. C., Liu, J., Rouwkema, J., de Boer, J. & van Blitterswijk, C., 2008, In : European cells & materials. 15, p. 27-40

Research output: Contribution to journalArticleAcademicpeer-review

File
25 Citations (Scopus)

Trends in biomaterials research: An analysis of the scientific programma of the World Biomaterials Congress 2008

Leeuwenburgh, S. C. G., Jansen, J. A., Malda, J., Dhert, W. A., Rouwkema, J., van Blitterswijk, C., Kirkpatrick, C. J. & Williams, D. F., 2008, In : Biomaterials. 29, 21, p. 3047-3052 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

612 Citations (Scopus)

Vascularization Tissue Engineering

Rouwkema, J., Rivron, N. C. & van Blitterswijk, C., 2008, In : Trends in biotechnology. 26, 8, p. 434-441 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2007

Engineering vascularized microtissues for bone tissue engineering.

Rivron, N. C., Rouwkema, J., de Boer, J., van Blitterswijk, C., Bettahalli Narasimha, M. S., Stamatialis, D. & Wessling, M., 2007, In : Tissue engineering. 13, 7, p. 1689-

Research output: Contribution to journalArticleAcademicpeer-review

Hollow fiber membrane to reduce necrosis in tissue engineered constructs.

Narasimha, M. S. B., Rivron, N. C., Rouwkema, J., Stamatialis, D., van Blitterswijk, C. & Wessling, M., 2007, In : Tissue engineering. 13, 7, p. 1704-

Research output: Contribution to journalArticleAcademicpeer-review

2006
242 Citations (Scopus)

Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct

Rouwkema, J., de Boer, J. & van Blitterswijk, C., 2006, In : Tissue engineering. 12, 9, p. 2685-2693

Research output: Contribution to journalArticleAcademicpeer-review

2005
855 Citations (Scopus)

Engineering vascularized skeletal muscle tissue

Levenberg, S., Rouwkema, J., Macdonald, M., Garfein, E. S., Kohane, D. S., Darland, D. C., Marini, R., van Blitterswijk, C., Mulligan, R. C., D'Amore, P. A. & Langer, R., 2005, In : Nature biotechnology. 23, 7, p. 879-884

Research output: Contribution to journalArticleAcademicpeer-review

2004
224 Citations (Scopus)

Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling

Malda, J., Rouwkema, J., Martens, D. E., le Comte, EP., Kooy, F. K., Tramper, J., van Blitterswijk, C. & Riesle, J. U., 2004, In : Biotechnology and bioengineering. 86, 1, p. 9-18

Research output: Contribution to journalArticleAcademicpeer-review