• 1715 Citations
  • 14 h-Index
20012019
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Research Output 2001 2019

2019
49 Downloads (Pure)
Open Access
File
SOX9 Transcription Factor
Fluorescence Recovery After Photobleaching
Photobleaching
Transcription Factors
Fluorescence
19 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Oxygen
Cartilage Diseases
Matrix Metalloproteinases
Cartilage

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194

Research output: Contribution to journalMeeting AbstractAcademic

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Synovial Fluid
Osteoarthritis
Inflammation
Proteins
Fluids
2018
3 Citations (Scopus)
21 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Transforming Growth Factors
Chondrocytes
Osteoarthritis
Oxygen
Gene Expression
4 Citations (Scopus)
19 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Knee Injuries
Synovial Fluid
Osteoarthritis
Proteins
Fluids

Mitochondrial changes of articular chondrocytes revealed by omics analyses

Bakker, B., Eijkel, G., Mohren, R., Heeren, R., Karperien, M., Post, J. & Cillero-Pastor, B., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S170-S171 332.

Research output: Contribution to journalMeeting AbstractAcademic

5 Citations (Scopus)

RUNX2 and SOX9 protein mobility correlates to osteogenic and chondrogenic differentiation of mesenchymal stem cells

Khurana, S., Govindaraj, K., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S109-S110 201.

Research output: Contribution to journalMeeting AbstractAcademic

SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes

Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S106-S107 195.

Research output: Contribution to journalMeeting AbstractAcademic

6 Citations (Scopus)
45 Downloads (Pure)

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stem cells
Stem cells
Mesenchymal Stromal Cells
Modulators
modulators
2017

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

70 Downloads (Pure)

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
File
Computational Modeling
Computer Simulation
Molecular interactions
Proteins
Protein
8 Citations (Scopus)

High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.

Research output: Contribution to journalMeeting AbstractAcademic

2 Citations (Scopus)

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

Ghebes, C-A., van Lente, J., Post, J. N., Saris, D. B. F. & Fernandes, H., 1 Jan 2017, In : SLAS DISCOVERY: Advancing Life Sciences R&D. 22, 1, p. 40-50 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-Throughput Screening Assays
Bone Morphogenetic Protein 2
Assays
Intercellular Signaling Peptides and Proteins
Screening
51 Downloads (Pure)

Improving the Timed Automata Approach to Biological Pathway Dynamics

Langerak, R., van de Pol, J., Post, J. N. & Schivo, S., 19 Aug 2017, Models, Algorithms, Logics and Tools: Essays Dedicated to Kim Guldstrand Larsen on the Occasion of His 60th Birthday. Aceto, L., Bacci, G., Bacci, G., Ingólfsdóttir, A., Legay, A. & Mardare, R. (eds.). Springer, p. 96-111 16 p. (Lecture Notes in Computer Science; vol. 10460).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Computer science
Model checking
Biological systems
User interfaces
Genes
11 Citations (Scopus)
41 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
interleukins
Nitric oxide
nitric oxide
Chondrocytes
Crosstalk
8 Downloads (Pure)

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Welting, T. J. M., Karperien, M. & Post, J. N., 17 Jul 2017, In : Biotarget. 2, 11, 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Cartilage
Growth Plate
Articular Cartilage
Bone and Bones
4 Citations (Scopus)
37 Downloads (Pure)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2016
34 Downloads (Pure)

Ab intra extraque: how the kinome regulates cell fate

Scholma, J., 7 Jul 2016, Enschede: Universiteit Twente. 209 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

File
18 Downloads (Pure)

An ECHO in biology II: Insights in chondrocyte cell fate

Schivo, S., Scholma, J., Huang, X., Huang, X., Zhong, L., Zhong, L., van de Pol, J. C., Karperien, H. B. J., Langerak, R. & Post, J. N., Apr 2016, p. S176-S177. 1 p.

Research output: Contribution to conferenceAbstractOther research output

File
Chondrocytes
Computer Simulation
Joints
Cartilage Diseases
Ligands
5 Citations (Scopus)
30 Downloads (Pure)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
chondrocytes
Chondrocytes
hypertrophy
Dynamic analysis
Hypertrophy
26 Citations (Scopus)
77 Downloads (Pure)

Correlation between Gene Expression and Osteoarthritis Progression in Human

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 2016, In : International journal of molecular sciences. 17, 7, p. - 14 p., 1126.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cartilage
gene expression
Cartilage
Gene expression
progressions
44 Downloads (Pure)

DKK1AND FRZB are necessary for chondrocyte (RE) differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells

Zhong, L., Huang, X., Rodrigues, E., Leijten, J., Verrips, T., El Khattabi, M., Karperien, M. & Post, J., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S142 229.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Chondrocytes
Stem cells
Mesenchymal Stromal Cells
Cell culture
Hypertrophy
11 Citations (Scopus)
46 Downloads (Pure)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrogenesis
Chondrocytes
Mesenchymal Stromal Cells
Hypertrophy
Coculture Techniques
4 Citations (Scopus)
11 Downloads (Pure)

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots

Scholma, J., Fuhler, G. M., Joore, J., Hulsman, M., Schivo, S., List, A. F., Reinders, M. J. T., Peppelenbosch, M. P. & Post, J. N., 26 May 2016, In : Scientific reports. 6, 13 p., 26695.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Phosphorylation
Peptides
Phosphotransferases
Housekeeping
Gene Expression Profiling
61 Downloads (Pure)

Joint players: Endogenous WNT antagonists determine joint health

Zhong, L., 31 Aug 2016, Enschede: Universiteit Twente. 218 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

Open Access
File
Chondrocytes
Osteoarthritis
Joints
Health
Articular Cartilage
11 Citations (Scopus)
35 Downloads (Pure)

Lysozyme self-assembles into amyloid networks that support cartilage tissue formation

van Dalen, M., Post, J., Karperien, M. & Claessens, M. M. A. E., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S465 794.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Cartilage
Muramidase
Catalyst supports
Amyloid
Tissue Engineering
9 Citations (Scopus)
2 Downloads (Pure)

Modelling with ANIMO: between fuzzy logic and differential equations

Schivo, S., Scholma, J., van der Vet, P. E., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R., 27 Jul 2016, In : BMC systems biology. 10, p. 56 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
35 Downloads (Pure)

Oxygen regulates lipid profiles in human primary chondrocyte cultures

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero Pastor, B., 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S456-S457 779.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Chondrocytes
Lipids
Oxygen
Cartilage
Osteoarthritis
2015

Designer Peptide

Post, J. N., Karperien, H. B. J. & Scholma, J., 2015, (In preparation) Patent No. 62261676, Priority date 1 Dec 2015

Research output: PatentProfessional

14 Citations (Scopus)
1 Downloads (Pure)

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 5 Mar 2015, In : Analytical chemistry. 87, 7, p. 3981-3988 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Secondary ion mass spectrometry
Stem cells
Fibroblast Growth Factor 1
Oxygen
Lipids
4 Citations (Scopus)
59 Downloads (Pure)

Engineering Cartilage Tissue by Pellet Coculture of Chondrocytes and Mesenchymal Stromal Cells

Wu, L., Post, J. N. & Karperien, H. B. J., 2015, Osteoporosis and Osteoarthritis. Westendorf, J. J. & van Wijnen, A. J. (eds.). New York: Springer, p. 31-41 10 p. (Methods in molecular biology; vol. 1226, no. 1226).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

File
Tissue Engineering
Chondrocytes
Coculture Techniques
Mesenchymal Stromal Cells
Cartilage
3 Citations (Scopus)
56 Downloads (Pure)

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

Georgi, N., Taipaleenmaeki, H., Raiss, C. C., Groen, N., Portalska, K. K., van Blitterswijk, C., de Boer, J., Post, J. N., van Wijnen, A. & Karperien, H. B. J., 27 Apr 2015, In : Stem cells and development. 24, 16, p. 1946-1955 47 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
Differentiation Antigens
MicroRNAs
Mesenchymal Stromal Cells
Chondrogenesis
Messenger RNA

Synovial fluid concentration of Gremlin1 but not frizzled-related protein is increased in patients after acute knee injury

Zhong, L., Leijten, J. C. H., Post, J. N., Larsson, S., Karperien, H. B. J. & Struglics, A., Apr 2015, p. -.

Research output: Contribution to conferenceAbstractOther research output

Knee Injuries
Synovial Fluid
Cartilage
Wounds and Injuries
Knee
42 Citations (Scopus)
86 Downloads (Pure)

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 14 Aug 2015, In : International journal of molecular sciences. 16, 8, p. 19225-19247

Research output: Contribution to journalArticleAcademicpeer-review

File
stem cells
Chondrocytes
Crosstalk
Stem cells
crosstalk
2014
52 Downloads (Pure)

An echo in biology: validating the executable chondrocyte

Scholma, J., Schivo, S., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 1 Apr 2014, 2014 World Congress on Osteoarthritis. Supplement ed. Amsterdam: Elsevier, Vol. 22. p. S157-S157 1 p. (Osteoarthritis and Cartilage; vol. 22).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

File
Chondrocytes
Cartilage
Osteogenesis
Catenins
Osteoarthritis
44 Downloads (Pure)

ANIMO: a tool for modeling biological pathway dynamics

Schivo, S., Scholma, J., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 9 Jun 2014, p. 54-55. 2 p.

Research output: Contribution to conferenceAbstractOther research output

File
11 Citations (Scopus)

Biological networks 101: computational modeling for molecular biologists

Scholma, J., Schivo, S., Urquidi Camacho, R. A., van de Pol, J. C., Karperien, H. B. J. & Post, J. N., 1 Jan 2014, In : Gene. 533, 42, p. 379-384 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Models
Mathematics
Chondrocytes
Signal Transduction
Software
1 Citation (Scopus)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line

Landman, E., Periyasamy, P. C., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 2014, In : Cartilage. 5, 3, p. 181-189

Research output: Contribution to journalArticleAcademicpeer-review

Chondrocytes
Cells
Modulation
Cell Line
Gene expression
10 Downloads (Pure)

DKK1 FRZB GREM1 Prevent IL1 Induced Articular Cartilage Degradation

Zhong, L., Karperien, H. B. J. & Post, J. N., 24 Apr 2014, p. -.

Research output: Contribution to conferenceAbstractOther research output

File
22 Downloads (Pure)

ECHO: the executable chondrocyte

Scholma, J., Schivo, S., Kerkhofs, J., Langerak, R., Karperien, H. B. J., van de Pol, J. C., Geris, L. & Post, J. N., 9 Jun 2014, Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting. Malden: Wiley, p. 54-54 1 p. (s1; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

File

Lipids as mediators of chondrogenesis

Georgi, N., Cillero Pastor, B., Eijkel, G., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 24 Apr 2014, p. S46-S48.

Research output: Contribution to conferenceAbstractOther research output

58 Citations (Scopus)
34 Downloads (Pure)

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Leijten, J., Georgi, N., Moreira Teixeira, L., van Blitterswijk, C., Post, J. N. & Karperien, M., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13954-13959

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mesenchymal Stromal Cells
Cartilage
Articular Cartilage
Oxygen
Hyaline Cartilage
7 Citations (Scopus)

Modelling biological pathway dynamics with Timed Automata

Schivo, S., Scholma, J., Wanders, B., Urquidi Camacho, R. A., van der Vet, P. E., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., May 2014, In : IEEE journal of biomedical and health informatics. 18, 3, p. 832-839 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

42 Downloads (Pure)

Protein fibrils as scaffold material for cartilage tissue engineering - effects on cell viability and proliferation

van Dalen, M. C. E., Karperien, H. B. J., Subramaniam, V., Claessens, M. M. A. E. & Post, J. N., 24 Apr 2014, p. -.

Research output: Contribution to conferenceAbstractOther research output

File
6 Citations (Scopus)
35 Downloads (Pure)

Setting Parameters for Biological Models With ANIMO

Schivo, S., Scholma, J., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R., 8 Apr 2014, Proceedings 1st International Workshop on Synthesis of Continuous Parameters. André, É. & Frehse, G. (eds.). Open Publishing Association, p. 35-47 13 p. (Electronic Proceedings in Theoretical Computer Science; vol. 145).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

File
2013
10 Citations (Scopus)

Effect of radiation on the Notch signaling pathway in osteoblasts

Yang, B., Tang, Q., Post, J., Zhou, H., Huang, X-B., Zhang, X-D., Wang, Q., Sun, Y-M. & Fan, F-Y., 2013, In : International journal of molecular medicine. 31, 3, p. 698-706

Research output: Contribution to journalArticleAcademicpeer-review

Radiation Effects
Osteoblasts
Cell Differentiation
Radiation
Notch Receptors
42 Citations (Scopus)
39 Downloads (Pure)

Fibroblast growth factor-1 is a mesenchymal stromal cell secreted factor stimulating proliferation of Osteoarthritic chondrocytes

Ling, W., Leijten, J. C. H., Post, J. N. & Karperien, H. B. J., 18 Apr 2013, p. -. 2 p.

Research output: Contribution to conferenceAbstractOther research output

File