J.N. Post

dr.ing.

  • 1842 Citations
  • 15 h-Index
20012020

Research output per year

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Research Output

2020

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 1 Apr 2020, In : Cellular Signalling. 68, 109471.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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5 Downloads (Pure)
2019
Open Access
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1 Citation (Scopus)
83 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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52 Downloads (Pure)

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194

Research output: Contribution to journalMeeting AbstractAcademic

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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3 Citations (Scopus)
32 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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8 Citations (Scopus)
35 Downloads (Pure)

Mitochondrial changes of articular chondrocytes revealed by omics analyses

Bakker, B., Eijkel, G., Mohren, R., Heeren, R., Karperien, M., Post, J. & Cillero-Pastor, B., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S170-S171 332.

Research output: Contribution to journalMeeting AbstractAcademic

RUNX2 and SOX9 protein mobility correlates to osteogenic and chondrogenic differentiation of mesenchymal stem cells

Khurana, S., Govindaraj, K., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S109-S110 201.

Research output: Contribution to journalMeeting AbstractAcademic

7 Citations (Scopus)

SOX9 transcriptional activity is differentially regulated in healthy and osteoarthritic chondrocytes

Govindaraj, K., Khurana, S., Karperien, M. & Post, J. N., Apr 2018, In : Osteoarthritis and cartilage. 26, supplement 1, p. S106-S107 195.

Research output: Contribution to journalMeeting AbstractAcademic

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
57 Downloads (Pure)
2017

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
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92 Downloads (Pure)

High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.

Research output: Contribution to journalMeeting AbstractAcademic

16 Citations (Scopus)

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

Ghebes, C-A., van Lente, J., Post, J. N., Saris, D. B. F. & Fernandes, H., 1 Jan 2017, In : SLAS DISCOVERY: Advancing Life Sciences R&D. 22, 1, p. 40-50 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Improving the Timed Automata Approach to Biological Pathway Dynamics

Langerak, R., van de Pol, J., Post, J. N. & Schivo, S., 19 Aug 2017, Models, Algorithms, Logics and Tools: Essays Dedicated to Kim Guldstrand Larsen on the Occasion of His 60th Birthday. Aceto, L., Bacci, G., Bacci, G., Ingólfsdóttir, A., Legay, A. & Mardare, R. (eds.). Springer, p. 96-111 16 p. (Lecture Notes in Computer Science; vol. 10460).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
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1 Citation (Scopus)
66 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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14 Citations (Scopus)
60 Downloads (Pure)

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Welting, T. J. M., Karperien, M. & Post, J. N., 17 Jul 2017, In : Biotarget. 2, 11, 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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26 Downloads (Pure)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
49 Downloads (Pure)
2016

An ECHO in biology II: Insights in chondrocyte cell fate

Schivo, S., Scholma, J., Huang, X., Huang, X., Zhong, L., Zhong, L., van de Pol, J. C., Karperien, H. B. J., Langerak, R. & Post, J. N., Apr 2016, p. S176-S177. 1 p.

Research output: Contribution to conferenceAbstract

File
21 Downloads (Pure)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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7 Citations (Scopus)
45 Downloads (Pure)

Correlation between Gene Expression and Osteoarthritis Progression in Human

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 2016, In : International journal of molecular sciences. 17, 7, p. - 14 p., 1126.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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37 Citations (Scopus)
92 Downloads (Pure)

DKK1AND FRZB are necessary for chondrocyte (RE) differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells

Zhong, L., Huang, X., Rodrigues, E., Leijten, J., Verrips, T., El Khattabi, M., Karperien, M. & Post, J., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S142 229.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
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60 Downloads (Pure)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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13 Citations (Scopus)
75 Downloads (Pure)

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots

Scholma, J., Fuhler, G. M., Joore, J., Hulsman, M., Schivo, S., List, A. F., Reinders, M. J. T., Peppelenbosch, M. P. & Post, J. N., 26 May 2016, In : Scientific reports. 6, 13 p., 26695.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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4 Citations (Scopus)
17 Downloads (Pure)

Lysozyme self-assembles into amyloid networks that support cartilage tissue formation

van Dalen, M., Post, J., Karperien, M. & Claessens, M. M. A. E., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S465 794.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
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12 Citations (Scopus)
57 Downloads (Pure)

Modelling with ANIMO: between fuzzy logic and differential equations

Schivo, S., Scholma, J., van der Vet, P. E., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R., 27 Jul 2016, In : BMC systems biology. 10, p. 56 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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10 Citations (Scopus)
2 Downloads (Pure)

Oxygen regulates lipid profiles in human primary chondrocyte cultures

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero Pastor, B., 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S456-S457 779.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
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53 Downloads (Pure)
2015

Designer Peptide

Post, J. N., Karperien, H. B. J. & Scholma, J., 2015, (In preparation) Patent No. 62261676, Priority date 1 Dec 2015

Research output: Patent

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 5 Mar 2015, In : Analytical chemistry. 87, 7, p. 3981-3988 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2 Downloads (Pure)

Engineering Cartilage Tissue by Pellet Coculture of Chondrocytes and Mesenchymal Stromal Cells

Wu, L., Post, J. N. & Karperien, H. B. J., 2015, Osteoporosis and Osteoarthritis. Westendorf, J. J. & van Wijnen, A. J. (eds.). New York: Springer, p. 31-41 10 p. (Methods in molecular biology; vol. 1226, no. 1226).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

File
5 Citations (Scopus)
78 Downloads (Pure)

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

Georgi, N., Taipaleenmaeki, H., Raiss, C. C., Groen, N., Portalska, K. K., van Blitterswijk, C., de Boer, J., Post, J. N., van Wijnen, A. & Karperien, H. B. J., 27 Apr 2015, In : Stem cells and development. 24, 16, p. 1946-1955 47 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
3 Citations (Scopus)
68 Downloads (Pure)

Synovial fluid concentration of Gremlin1 but not frizzled-related protein is increased in patients after acute knee injury

Zhong, L., Leijten, J. C. H., Post, J. N., Larsson, S., Karperien, H. B. J. & Struglics, A., Apr 2015, p. -.

Research output: Contribution to conferenceAbstract

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 14 Aug 2015, In : International journal of molecular sciences. 16, 8, p. 19225-19247

Research output: Contribution to journalArticleAcademicpeer-review

File
54 Citations (Scopus)
124 Downloads (Pure)
2014

An echo in biology: validating the executable chondrocyte

Scholma, J., Schivo, S., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 1 Apr 2014, 2014 World Congress on Osteoarthritis. Supplement ed. Amsterdam: Elsevier, Vol. 22. p. S157-S157 1 p. (Osteoarthritis and Cartilage; vol. 22).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

File
65 Downloads (Pure)

ANIMO: a tool for modeling biological pathway dynamics

Schivo, S., Scholma, J., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 9 Jun 2014, p. 54-55. 2 p.

Research output: Contribution to conferenceAbstract

File
62 Downloads (Pure)

Biological networks 101: computational modeling for molecular biologists

Scholma, J., Schivo, S., Urquidi Camacho, R. A., van de Pol, J. C., Karperien, H. B. J. & Post, J. N., 1 Jan 2014, In : Gene. 533, 42, p. 379-384 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line

Landman, E., Periyasamy, P. C., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 2014, In : Cartilage. 5, 3, p. 181-189

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

DKK1 FRZB GREM1 Prevent IL1 Induced Articular Cartilage Degradation

Zhong, L., Karperien, H. B. J. & Post, J. N., 24 Apr 2014, p. -.

Research output: Contribution to conferenceAbstract

File
13 Downloads (Pure)

ECHO: the executable chondrocyte

Scholma, J., Schivo, S., Kerkhofs, J., Langerak, R., Karperien, H. B. J., van de Pol, J. C., Geris, L. & Post, J. N., 9 Jun 2014, Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting. Malden: Wiley, p. 54-54 1 p. (s1; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

File
37 Downloads (Pure)

Lipids as mediators of chondrogenesis

Georgi, N., Cillero Pastor, B., Eijkel, G., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 24 Apr 2014, p. S46-S48.

Research output: Contribution to conferenceAbstract

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Leijten, J., Georgi, N., Moreira Teixeira, L., van Blitterswijk, C., Post, J. N. & Karperien, M., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13954-13959

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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65 Citations (Scopus)
50 Downloads (Pure)

Modelling biological pathway dynamics with Timed Automata

Schivo, S., Scholma, J., Wanders, B., Urquidi Camacho, R. A., van der Vet, P. E., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., May 2014, In : IEEE journal of biomedical and health informatics. 18, 3, p. 832-839 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Protein fibrils as scaffold material for cartilage tissue engineering - effects on cell viability and proliferation

van Dalen, M. C. E., Karperien, H. B. J., Subramaniam, V., Claessens, M. M. A. E. & Post, J. N., 24 Apr 2014, p. -.

Research output: Contribution to conferenceAbstract

File
52 Downloads (Pure)

Setting Parameters for Biological Models With ANIMO

Schivo, S., Scholma, J., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R., 8 Apr 2014, Proceedings 1st International Workshop on Synthesis of Continuous Parameters. André, É. & Frehse, G. (eds.). Open Publishing Association, p. 35-47 13 p. (Electronic Proceedings in Theoretical Computer Science; vol. 145).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

File
6 Citations (Scopus)
50 Downloads (Pure)
2013

Amyloid Scaffolds for Cartilage Tissue Engineering: The Effect of Amyloid Structures on Cell Viability and Proliferation

van Dalen, M. C. E., Karperien, H. B. J., Subramaniam, V., Post, J. N. & Claessens, M. M. A. E., 30 Sep 2013, p. -.

Research output: Contribution to conferencePoster

Effect of radiation on the Notch signaling pathway in osteoblasts

Yang, B., Tang, Q., Post, J., Zhou, H., Huang, X-B., Zhang, X-D., Wang, Q., Sun, Y-M. & Fan, F-Y., 2013, In : International journal of molecular medicine. 31, 3, p. 698-706

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
49 Citations (Scopus)
48 Downloads (Pure)

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

Ma, B., Leijten, J. C. H., Wu, L., Kip, M. M. A., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 30 Jan 2013, In : Osteoarthritis and cartilage. 21, 4, p. 599-603 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
96 Citations (Scopus)
56 Downloads (Pure)