J.N. Post

dr.ing.

  • 1732 Citations
  • 14 h-Index
20012019
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Research Output 2001 2019

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

55 Downloads (Pure)

An echo in biology: validating the executable chondrocyte

Scholma, J., Schivo, S., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 1 Apr 2014, 2014 World Congress on Osteoarthritis. Supplement ed. Amsterdam: Elsevier, Vol. 22. p. S157-S157 1 p. (Osteoarthritis and Cartilage; vol. 22).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

File
Chondrocytes
Cartilage
Osteogenesis
Catenins
Osteoarthritis
18 Downloads (Pure)

An ECHO in biology II: Insights in chondrocyte cell fate

Schivo, S., Scholma, J., Huang, X., Huang, X., Zhong, L., Zhong, L., van de Pol, J. C., Karperien, H. B. J., Langerak, R. & Post, J. N., Apr 2016, p. S176-S177. 1 p.

Research output: Contribution to conferenceAbstract

File
Chondrocytes
Computer Simulation
Joints
Cartilage Diseases
Ligands
46 Downloads (Pure)

ANIMO: a tool for modeling biological pathway dynamics

Schivo, S., Scholma, J., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., 9 Jun 2014, p. 54-55. 2 p.

Research output: Contribution to conferenceAbstract

File
5 Citations (Scopus)
36 Downloads (Pure)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
chondrocytes
Chondrocytes
hypertrophy
Dynamic analysis
Hypertrophy
11 Citations (Scopus)

Biological networks 101: computational modeling for molecular biologists

Scholma, J., Schivo, S., Urquidi Camacho, R. A., van de Pol, J. C., Karperien, H. B. J. & Post, J. N., 1 Jan 2014, In : Gene. 533, 42, p. 379-384 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Models
Mathematics
Chondrocytes
Signal Transduction
Software
55 Downloads (Pure)
Open Access
File
SOX9 Transcription Factor
Fluorescence Recovery After Photobleaching
Photobleaching
Transcription Factors
Fluorescence

Chromatin remodeling during stem cell differentiation

de Boer, F., Kruijer, W. & Post, J. N., 2005, Enschede: Werkeenheid Polymeerchemie en Biomaterialen.

Research output: Book/ReportReportProfessional

75 Downloads (Pure)

Computational Modeling of Complex Protein Activity Networks

Schivo, S., Leijten, J., Karperien, M. & Post, J. N., 29 Nov 2017, Protein Phosphorylation. Prignet, C. (ed.). IntechOpen, p. 155-178 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Open Access
File
Computational Modeling
Computer Simulation
Molecular interactions
Proteins
Protein
26 Citations (Scopus)
81 Downloads (Pure)

Correlation between Gene Expression and Osteoarthritis Progression in Human

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 2016, In : International journal of molecular sciences. 17, 7, p. - 14 p., 1126.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cartilage
gene expression
Cartilage
Gene expression
progressions
3 Citations (Scopus)
22 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Transforming Growth Factors
Chondrocytes
Osteoarthritis
Oxygen
Gene Expression

Designer Peptide

Post, J. N., Karperien, H. B. J. & Scholma, J., 2015, (In preparation) Patent No. 62261676, Priority date 1 Dec 2015

Research output: Patent

Developmentally regulated cytoplasmic retention of the transcription factor XMI-ER1 requires sequence in the acidic activation domain

Post, J. N., Luchman, H. A., Mercer, F. C., Paterno, G. D. & Gillespie, L. L., 2005, In : International journal of biochemistry & cell biology. 37, 2, p. 463-477

Research output: Contribution to journalArticleAcademic

4 Citations (Scopus)
21 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Knee Injuries
Synovial Fluid
Osteoarthritis
Proteins
Fluids
14 Citations (Scopus)
1 Downloads (Pure)

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 5 Mar 2015, In : Analytical chemistry. 87, 7, p. 3981-3988 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Secondary ion mass spectrometry
Stem cells
Fibroblast Growth Factor 1
Oxygen
Lipids
28 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Oxygen
Cartilage Diseases
Matrix Metalloproteinases
Cartilage
1 Citation (Scopus)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line

Landman, E., Periyasamy, P. C., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 2014, In : Cartilage. 5, 3, p. 181-189

Research output: Contribution to journalArticleAcademicpeer-review

Chondrocytes
Cells
Modulation
Cell Line
Gene expression
47 Downloads (Pure)

DKK1AND FRZB are necessary for chondrocyte (RE) differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells

Zhong, L., Huang, X., Rodrigues, E., Leijten, J., Verrips, T., El Khattabi, M., Karperien, M. & Post, J., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S142 229.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Chondrocytes
Stem cells
Mesenchymal Stromal Cells
Cell culture
Hypertrophy
10 Downloads (Pure)

DKK1 FRZB GREM1 Prevent IL1 Induced Articular Cartilage Degradation

Zhong, L., Karperien, H. B. J. & Post, J. N., 24 Apr 2014, p. -.

Research output: Contribution to conferenceAbstract

File
8 Citations (Scopus)

Dynamic and static fluorescence anisotropy in biological microscopy (rFLIM and emFRET)

Jovin, T. M., Lidke, D. S. & Post, J. N., 2004, In : Progress in Biomedical Optics and Imaging. 5323, p. 1-12

Research output: Contribution to journalArticleAcademic

2 Downloads (Pure)

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., Pol, J. V. D., Langerak, R., Wijnen, A. J. V., Geris, L., Karperien, M. & Post, J. N., 11 Dec 2019, In : Cellular Signalling.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Joints
Interleukin-1beta
Computer Simulation
Cartilage
25 Downloads (Pure)

ECHO: the executable chondrocyte

Scholma, J., Schivo, S., Kerkhofs, J., Langerak, R., Karperien, H. B. J., van de Pol, J. C., Geris, L. & Post, J. N., 9 Jun 2014, Tissue Engineering & Regenerative Medicine International Society, European Chapter Meeting. Malden: Wiley, p. 54-54 1 p. (s1; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

File
10 Citations (Scopus)

Effect of radiation on the Notch signaling pathway in osteoblasts

Yang, B., Tang, Q., Post, J., Zhou, H., Huang, X-B., Zhang, X-D., Wang, Q., Sun, Y-M. & Fan, F-Y., 2013, In : International journal of molecular medicine. 31, 3, p. 698-706

Research output: Contribution to journalArticleAcademicpeer-review

Radiation Effects
Osteoblasts
Cell Differentiation
Radiation
Notch Receptors

Efficiente cel transfectie met microchip electroporatie

Bömer, N., Post, J. N., Lüttge, R. & Kruijer, W., 2005, Enschede: Werkeenheid Polymeerchemie en Biomaterialen. 41 p.

Research output: Book/ReportReportProfessional

11 Citations (Scopus)
50 Downloads (Pure)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrogenesis
Chondrocytes
Mesenchymal Stromal Cells
Hypertrophy
Coculture Techniques
5 Citations (Scopus)
66 Downloads (Pure)

Engineering Cartilage Tissue by Pellet Coculture of Chondrocytes and Mesenchymal Stromal Cells

Wu, L., Post, J. N. & Karperien, H. B. J., 2015, Osteoporosis and Osteoarthritis. Westendorf, J. J. & van Wijnen, A. J. (eds.). New York: Springer, p. 31-41 10 p. (Methods in molecular biology; vol. 1226, no. 1226).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

File
Tissue Engineering
Chondrocytes
Coculture Techniques
Mesenchymal Stromal Cells
Cartilage
65 Citations (Scopus)
43 Downloads (Pure)

ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation

Lidke, D. S., Huang, F., Post, J. N., Rieger, B., Wilsbacher, J., Thomas, J. L., Pouyssegur, J., Jovin, T. M. & Lenormand, P., 2010, In : Journal of biological chemistry. 285, 5, p. 3092-3102

Research output: Contribution to journalArticleAcademicpeer-review

File
10 Citations (Scopus)
47 Downloads (Pure)

Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage

van Gool, S. A., Emons, J. A. M., Leijten, J. C. H., Decker, E., Sticht, C., van Houwelingen, J. C., Goeman, J. J., Kleijburg, C., Scherjon, S., Gretz, N., Wit, J. M., Rappold, G., Post, J. N. & Karperien, H. B. J., 2012, In : PLoS ONE. 7, 11, p. 1-11 11 p., e44561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
growth plate
Growth Plate
human growth
stromal cells
chondrocytes
43 Citations (Scopus)
40 Downloads (Pure)
File
83 Citations (Scopus)
45 Downloads (Pure)

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

Ma, B., Leijten, J. C. H., Wu, L., Kip, M. M. A., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 30 Jan 2013, In : Osteoarthritis and cartilage. 21, 4, p. 599-603 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
Gene Expression Profiling
Chondrocytes
Gene expression
Monolayers
Joints
2 Citations (Scopus)

Gene transfer and characterization of protein dynamcis in stem cells using single cell electroporation in a microfluidic device

Valero, A., Post, J. N., Van Nieuwkasteele, J. W., Kruijer, W., Andersson, H. & Van Den Berg, A., 1 Jan 2006, p. 22-24. 3 p.

Research output: Contribution to conferencePaper

Gene transfer
Stem cells
Microfluidics
Genes
Proteins

Gene transfer and characterization of protein dynamics in stem cells using single cell electroporation in a microfluidic device

Valero, A., Post, J. N., van Nieuwkasteele, J. W., Kruijer, W., Andersson, H. & van den Berg, A., Nov 2006, Proceedings of microTAS 2006 Conference. Kitamori, T., Fujita, H. & Hasebe, S. (eds.). Tokyo, Japan: Japan Academic Association Inc, p. 22-24 3 p. (Micro Total Analysis Systems; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

125 Citations (Scopus)
1 Downloads (Pure)

Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Valero, A., Post, J. N., van Nieuwkasteele, J. W., ter Braak, P. M., Kruijer, W. & van den Berg, A., Jan 2008, In : Lab on a chip. 8, 1, p. 62-67 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

Emons, J., Dutilh, B. E., Decker, E., Pirzer, H., Sticht, C., Gretz, N., Rappold, G., Cameron, E. R., Neil, J. C., Stein, G. S., van Wijnen, A. J., Wit, J. M., Post, J. N. & Karperien, H. B. J., 2011, In : Journal of endocrinology. 209, 2, p. 245-254

Research output: Contribution to journalArticleAcademicpeer-review

Growth Plate
Puberty
Genome
Genes
Estrogen Receptors
30 Citations (Scopus)
54 Downloads (Pure)

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis associated factors

Leijten, J. C. H., Bos, S. D., Landman, E., Georgi, N., Jahr, H., Meulenbelt, I., Post, J. N., van Blitterswijk, C. & Karperien, H. B. J., 19 Sep 2013, In : Arthritis research & therapy. 15, 5, p. 1-11 R126.

Research output: Contribution to journalArticleAcademicpeer-review

File
Bone Morphogenetic Proteins
Osteoarthritis
Cartilage
Bone Morphogenetic Protein 1
Articular Cartilage
8 Citations (Scopus)

High oxygen levels increase mitochondrial lipids in human osteoarthritic chondrocytes

Bakker, B., Eijkel, G. B., Heeren, R. M., Karperien, M., Post, J. N. & Cillero-Pastor, B., Apr 2017, In : Osteoarthritis and cartilage. 25, p. S146-S147 212.

Research output: Contribution to journalMeeting AbstractAcademic

2 Citations (Scopus)

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

Ghebes, C-A., van Lente, J., Post, J. N., Saris, D. B. F. & Fernandes, H., 1 Jan 2017, In : SLAS DISCOVERY: Advancing Life Sciences R&D. 22, 1, p. 40-50 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-Throughput Screening Assays
Bone Morphogenetic Protein 2
Assays
Intercellular Signaling Peptides and Proteins
Screening
126 Citations (Scopus)

Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET)

Lidke, D. S., Nagy, P., Barisas, B. G., Heintzmann, R., Post, J. N., Lidke, K. A., Clayton, A. H. A., Arndt-jovin, D. J. & Jovin, T. M., 2003, In : Biochemical Society transactions. 31, p. 1020-1027

Research output: Contribution to journalArticleAcademic

4 Citations (Scopus)
15 Downloads (Pure)

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots

Scholma, J., Fuhler, G. M., Joore, J., Hulsman, M., Schivo, S., List, A. F., Reinders, M. J. T., Peppelenbosch, M. P. & Post, J. N., 26 May 2016, In : Scientific reports. 6, 13 p., 26695.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Phosphorylation
Peptides
Phosphotransferases
Housekeeping
Gene Expression Profiling
52 Downloads (Pure)

Improving the Timed Automata Approach to Biological Pathway Dynamics

Langerak, R., van de Pol, J., Post, J. N. & Schivo, S., 19 Aug 2017, Models, Algorithms, Logics and Tools: Essays Dedicated to Kim Guldstrand Larsen on the Occasion of His 60th Birthday. Aceto, L., Bacci, G., Bacci, G., Ingólfsdóttir, A., Legay, A. & Mardare, R. (eds.). Springer, p. 96-111 16 p. (Lecture Notes in Computer Science; vol. 10460).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Open Access
File
Computer science
Model checking
Biological systems
User interfaces
Genes

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

Khurana, S., Bokkers, A., Geijs, D. J., Schivo, S., Karperien, M. & Post, J. N., Apr 2019, In : Osteoarthritis and cartilage. 27, suppl. 1, p. S193-S194

Research output: Contribution to journalMeeting AbstractAcademic

Investigation of nanoparticle drug delivery systems for the inhibition of p38-MAPK signaling in osteoarthritis

Periyasamy, P. C., Karperien, H. B. J. & Post, J. N., 13 Oct 2011, p. -.

Research output: Contribution to conferencePoster

Kinome analysis of stem cells

Koopman, H. F. J. M. (ed.), Scholma, J., Joore, J. T., Kanger, J. S. (ed.), Engbersen, J. F. J. (ed.), Post, J. N. & Kruijer, W., 20 Nov 2008, p. 67-69.

Research output: Contribution to conferencePaper

Lipids as mediators of chondrogenesis

Georgi, N., Cillero Pastor, B., Eijkel, G., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 24 Apr 2014, p. S46-S48.

Research output: Contribution to conferenceAbstract

12 Citations (Scopus)
36 Downloads (Pure)

Lysozyme self-assembles into amyloid networks that support cartilage tissue formation

van Dalen, M., Post, J., Karperien, M. & Claessens, M. M. A. E., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S465 794.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Cartilage
Muramidase
Catalyst supports
Amyloid
Tissue Engineering

Mathematical modeling of signaling pathways in osteoarthritis

Scholma, J., Kerkhofs, J., Schivo, S., Langerak, R., van der Vet, P. E., Karperien, H. B. J., van de Pol, J. C., Geris, L. & Post, J. N., 19 Apr 2013, 2013 Osteoarthritis Research Society International (OARSI) World Congress. Lohmander, S. (ed.). Amsterdam: Elsevier, p. - 1 p. (S123; vol. 21, no. Suppl.).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic