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Research Output 2001 2019

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Article
2019
48 Downloads (Pure)
Open Access
File
SOX9 Transcription Factor
Fluorescence Recovery After Photobleaching
Photobleaching
Transcription Factors
Fluorescence
17 Downloads (Pure)

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 1 Jan 2019, In : Journal of orthopaedic research. 37, 1, p. 84-93 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Oxygen
Cartilage Diseases
Matrix Metalloproteinases
Cartilage

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., Post, J. N. & Karperien, M., 4 Apr 2019, In : Cartilage.

Research output: Contribution to journalArticleAcademicpeer-review

Synovial Fluid
Osteoarthritis
Inflammation
Proteins
Fluids
2018
3 Citations (Scopus)
20 Downloads (Pure)

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments

Huang, X., Zhong, L., Post, J. N. & Karperien, M., 1 Dec 2018, In : Scientific reports. 8, 1, 10251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Transforming Growth Factors
Chondrocytes
Osteoarthritis
Oxygen
Gene Expression
4 Citations (Scopus)
17 Downloads (Pure)

Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M. & Struglics, A., Jun 2018, In : Osteoarthritis and cartilage. 26, 6, p. 834-843 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Knee Injuries
Synovial Fluid
Osteoarthritis
Proteins
Fluids
6 Citations (Scopus)
44 Downloads (Pure)

The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells

Huang, X., Zhong, L., Hendriks, J., Post, J. N. & Karperien, M., 13 Feb 2018, In : International journal of molecular sciences. 19, 2, 561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stem cells
Stem cells
Mesenchymal Stromal Cells
Modulators
modulators
2017
2 Citations (Scopus)

High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-β1 Signaling Pathway

Ghebes, C-A., van Lente, J., Post, J. N., Saris, D. B. F. & Fernandes, H., 1 Jan 2017, In : SLAS DISCOVERY: Advancing Life Sciences R&D. 22, 1, p. 40-50 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-Throughput Screening Assays
Bone Morphogenetic Protein 2
Assays
Intercellular Signaling Peptides and Proteins
Screening
11 Citations (Scopus)
40 Downloads (Pure)

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Zhong, L., Schivo, S., Huang, X., Leijten, J., Karperien, M. & Post, J. N., 22 Nov 2017, In : International journal of molecular sciences. 18, 11, 18 p., 2491.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
interleukins
Nitric oxide
nitric oxide
Chondrocytes
Crosstalk
7 Downloads (Pure)

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Welting, T. J. M., Karperien, M. & Post, J. N., 17 Jul 2017, In : Biotarget. 2, 11, 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrocytes
Cartilage
Growth Plate
Articular Cartilage
Bone and Bones
4 Citations (Scopus)
35 Downloads (Pure)

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI

Bakker, B., Eijkel, G. B., Heeren, R. M. A., Karperien, M., Post, J. N. & Cillero-Pastor, B., 5 Sep 2017, In : Analytical chemistry. 89, 17, p. 9438-9444 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2016
5 Citations (Scopus)
29 Downloads (Pure)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy

Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N. & Geris, L., 2016, In : PLoS ONE. 11, 8, 27 p., e0162052.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
chondrocytes
Chondrocytes
hypertrophy
Dynamic analysis
Hypertrophy
26 Citations (Scopus)
77 Downloads (Pure)

Correlation between Gene Expression and Osteoarthritis Progression in Human

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 2016, In : International journal of molecular sciences. 17, 7, p. - 14 p., 1126.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
cartilage
gene expression
Cartilage
Gene expression
progressions
11 Citations (Scopus)
44 Downloads (Pure)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Zhong, L., Huang, X., Rodrigues, E. D., Leijten, J. C. H., Verrips, T., El Khattabi, M., Karperien, H. B. J. & Post, J. N., 27 Oct 2016, In : Stem cells and development. 25, 23, p. 1808-1817

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Chondrogenesis
Chondrocytes
Mesenchymal Stromal Cells
Hypertrophy
Coculture Techniques
4 Citations (Scopus)
11 Downloads (Pure)

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots

Scholma, J., Fuhler, G. M., Joore, J., Hulsman, M., Schivo, S., List, A. F., Reinders, M. J. T., Peppelenbosch, M. P. & Post, J. N., 26 May 2016, In : Scientific reports. 6, 13 p., 26695.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Phosphorylation
Peptides
Phosphotransferases
Housekeeping
Gene Expression Profiling
9 Citations (Scopus)
2 Downloads (Pure)

Modelling with ANIMO: between fuzzy logic and differential equations

Schivo, S., Scholma, J., van der Vet, P. E., Karperien, H. B. J., Post, J. N., van de Pol, J. C. & Langerak, R., 27 Jul 2016, In : BMC systems biology. 10, p. 56 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2015
14 Citations (Scopus)
1 Downloads (Pure)

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, H. B. J., 5 Mar 2015, In : Analytical chemistry. 87, 7, p. 3981-3988 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Secondary ion mass spectrometry
Stem cells
Fibroblast Growth Factor 1
Oxygen
Lipids
3 Citations (Scopus)
56 Downloads (Pure)

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

Georgi, N., Taipaleenmaeki, H., Raiss, C. C., Groen, N., Portalska, K. K., van Blitterswijk, C., de Boer, J., Post, J. N., van Wijnen, A. & Karperien, H. B. J., 27 Apr 2015, In : Stem cells and development. 24, 16, p. 1946-1955 47 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
Differentiation Antigens
MicroRNAs
Mesenchymal Stromal Cells
Chondrogenesis
Messenger RNA
42 Citations (Scopus)
85 Downloads (Pure)

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

Zhong, L., Huang, X., Karperien, H. B. J. & Post, J. N., 14 Aug 2015, In : International journal of molecular sciences. 16, 8, p. 19225-19247

Research output: Contribution to journalArticleAcademicpeer-review

File
stem cells
Chondrocytes
Crosstalk
Stem cells
crosstalk
2014
11 Citations (Scopus)

Biological networks 101: computational modeling for molecular biologists

Scholma, J., Schivo, S., Urquidi Camacho, R. A., van de Pol, J. C., Karperien, H. B. J. & Post, J. N., 1 Jan 2014, In : Gene. 533, 42, p. 379-384 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Models
Mathematics
Chondrocytes
Signal Transduction
Software
1 Citation (Scopus)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line

Landman, E., Periyasamy, P. C., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 2014, In : Cartilage. 5, 3, p. 181-189

Research output: Contribution to journalArticleAcademicpeer-review

Chondrocytes
Cells
Modulation
Cell Line
Gene expression
58 Citations (Scopus)
33 Downloads (Pure)

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

Leijten, J., Georgi, N., Moreira Teixeira, L., van Blitterswijk, C., Post, J. N. & Karperien, M., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13954-13959

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Mesenchymal Stromal Cells
Cartilage
Articular Cartilage
Oxygen
Hyaline Cartilage
7 Citations (Scopus)

Modelling biological pathway dynamics with Timed Automata

Schivo, S., Scholma, J., Wanders, B., Urquidi Camacho, R. A., van der Vet, P. E., Karperien, H. B. J., Langerak, R., van de Pol, J. C. & Post, J. N., May 2014, In : IEEE journal of biomedical and health informatics. 18, 3, p. 832-839 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
10 Citations (Scopus)

Effect of radiation on the Notch signaling pathway in osteoblasts

Yang, B., Tang, Q., Post, J., Zhou, H., Huang, X-B., Zhang, X-D., Wang, Q., Sun, Y-M. & Fan, F-Y., 2013, In : International journal of molecular medicine. 31, 3, p. 698-706

Research output: Contribution to journalArticleAcademicpeer-review

Radiation Effects
Osteoblasts
Cell Differentiation
Radiation
Notch Receptors
82 Citations (Scopus)
43 Downloads (Pure)

Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture

Ma, B., Leijten, J. C. H., Wu, L., Kip, M. M. A., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 30 Jan 2013, In : Osteoarthritis and cartilage. 21, 4, p. 599-603 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
Gene Expression Profiling
Chondrocytes
Gene expression
Monolayers
Joints
30 Citations (Scopus)
50 Downloads (Pure)

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis associated factors

Leijten, J. C. H., Bos, S. D., Landman, E., Georgi, N., Jahr, H., Meulenbelt, I., Post, J. N., van Blitterswijk, C. & Karperien, H. B. J., 19 Sep 2013, In : Arthritis research & therapy. 15, 5, p. 1-11 R126.

Research output: Contribution to journalArticleAcademicpeer-review

File
Bone Morphogenetic Proteins
Osteoarthritis
Cartilage
Bone Morphogenetic Protein 1
Articular Cartilage
35 Downloads (Pure)

MicroRNAs are prognostic markers for the chondrogenic potential of MSCs

Georgi, N., Taipaleenmaki, H., van Wijnen, A., Groen, N., Janaeczek-Portalska, K., van Blitterswijk, C., de Boer, J., Post, J. N. & Karperien, H. B. J., 2013, In : Osteoarthritis and cartilage. 21, Suppl., p. S31-S32

Research output: Contribution to journalArticleAcademicpeer-review

File
66 Downloads (Pure)

Nanoparticle system for the local delivery of disease modifying osteoarthritic drugs

Periyasamy, P. C., Wennink, J. W. H., Wang, R., Karperien, H. B. J., Dijkstra, P. J. & Post, J. N., 2013, In : Osteoarthritis and cartilage. 21, Supplement, p. S303-S304

Research output: Contribution to journalArticleAcademicpeer-review

File
Nanoparticles
Pharmaceutical Preparations
Cartilage
Joints
Polyethylene glycols
33 Citations (Scopus)

TCF4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating NF-κB signaling

Ma, B., Zhong, L., van Blitterswijk, C., Post, J. N. & Karperien, H. B. J., 19 Apr 2013, In : Journal of biological chemistry. 288, p. 17552-17558

Research output: Contribution to journalArticleAcademicpeer-review

TCF Transcription Factors
Cartilage
Chondrocytes
Joints
Matrix Metalloproteinases
30 Citations (Scopus)

WNT Signaling and Cartilage: Of Mice and Men

Ma, B., Landman, E., Miclea, R. L., Wit, J. M., Robanus-Maandag, E. C., Post, J. N. & Karperien, H. B. J., 2013, In : Calcified tissue international. 92, 5, p. 399-411 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cartilage
Articular Cartilage
Chondrocytes
Regeneration
Extracellular Matrix
2012
10 Citations (Scopus)
44 Downloads (Pure)

Fetal Mesenchymal Stromal Cells Differentiating towards Chondrocytes Acquire a Gene Expression Profile Resembling Human Growth Plate Cartilage

van Gool, S. A., Emons, J. A. M., Leijten, J. C. H., Decker, E., Sticht, C., van Houwelingen, J. C., Goeman, J. J., Kleijburg, C., Scherjon, S., Gretz, N., Wit, J. M., Rappold, G., Post, J. N. & Karperien, H. B. J., 2012, In : PLoS ONE. 7, 11, p. 1-11 11 p., e44561.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
growth plate
Growth Plate
human growth
stromal cells
chondrocytes
5 Citations (Scopus)
101 Downloads (Pure)

Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

Periyasamy, P. C., Leijten, J. C. H., Dijkstra, P. J., Karperien, H. B. J. & Post, J. N., 2012, In : Journal of nanomaterials. 2012, 673968, p. - 13 p., 673968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Nanostructured materials
Cartilage
Drawing (graphics)
Pharmaceutical Preparations
Biopolymers
2011
2 Citations (Scopus)

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

Emons, J., Dutilh, B. E., Decker, E., Pirzer, H., Sticht, C., Gretz, N., Rappold, G., Cameron, E. R., Neil, J. C., Stein, G. S., van Wijnen, A. J., Wit, J. M., Post, J. N. & Karperien, H. B. J., 2011, In : Journal of endocrinology. 209, 2, p. 245-254

Research output: Contribution to journalArticleAcademicpeer-review

Growth Plate
Puberty
Genome
Genes
Estrogen Receptors

Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation

Wu, L., Leijten, J. C. H., Georgi, N., Post, J. N., van Blitterswijk, C. & Karperien, H. B. J., 2011, In : Tissue engineering. Part A. 17, 9-10, p. 1425-1436

Research output: Contribution to journalArticleAcademicpeer-review

Cartilage
Chondrocytes
Stem cells
Mesenchymal Stromal Cells
Coculture Techniques
2010
65 Citations (Scopus)
38 Downloads (Pure)

ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation

Lidke, D. S., Huang, F., Post, J. N., Rieger, B., Wilsbacher, J., Thomas, J. L., Pouyssegur, J., Jovin, T. M. & Lenormand, P., 2010, In : Journal of biological chemistry. 285, 5, p. 3092-3102

Research output: Contribution to journalArticleAcademicpeer-review

File
2008
123 Citations (Scopus)
1 Downloads (Pure)

Gene transfer and protein dynamics in stem cells using single cell electroporation in a microfluidic device

Valero, A., Post, J. N., van Nieuwkasteele, J. W., ter Braak, P. M., Kruijer, W. & van den Berg, A., Jan 2008, In : Lab on a chip. 8, 1, p. 62-67 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2007
101 Citations (Scopus)
73 Downloads (Pure)

Synthesis and bioconjugation of gold nanoparticles as potential molecular probes for light-based imaging techniques

Rayavarapu, R. G., Petersen, W., Ungureanu, C., Post, J. N., van Leeuwen, T. & Manohar, S., 2007, In : International Journal of Biomedical Imaging. p. 29817-1-29817-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
2005

Developmentally regulated cytoplasmic retention of the transcription factor XMI-ER1 requires sequence in the acidic activation domain

Post, J. N., Luchman, H. A., Mercer, F. C., Paterno, G. D. & Gillespie, L. L., 2005, In : International journal of biochemistry & cell biology. 37, 2, p. 463-477

Research output: Contribution to journalArticleAcademic

63 Citations (Scopus)

One- and two-photon photoactivation of a paGFP-fusion protein in live Drosophila embryos

Post, J. N., Lidke, K. A., Rieger, B. & Arndt-Jovin, D. J., 2005, In : FEBS letters. 579, 2, p. 325-330

Research output: Contribution to journalArticleAcademic

2004
8 Citations (Scopus)

Dynamic and static fluorescence anisotropy in biological microscopy (rFLIM and emFRET)

Jovin, T. M., Lidke, D. S. & Post, J. N., 2004, In : Progress in Biomedical Optics and Imaging. 5323, p. 1-12

Research output: Contribution to journalArticleAcademic

705 Citations (Scopus)

Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction

Lidke, D. S., Nagy, P., Heintzmann, R., Arndt-Jovin, D. J., Post, J. N., Grecco, H. E., Jares-Erijman, E. A. & Jovin, T. M., 2004, In : Nature biotechnology. 22, p. 198-203

Research output: Contribution to journalArticleAcademic

2003
125 Citations (Scopus)

Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET)

Lidke, D. S., Nagy, P., Barisas, B. G., Heintzmann, R., Post, J. N., Lidke, K. A., Clayton, A. H. A., Arndt-jovin, D. J. & Jovin, T. M., 2003, In : Biochemical Society transactions. 31, p. 1020-1027

Research output: Contribution to journalArticleAcademic

2001
9 Citations (Scopus)

Nuclear localization signals in the Xenopus FGF embryonic early response 1 protein

Post, J. N., Gillespie, L. L. & Paterno, G. D., 2001, In : FEBS letters. 502, 1-2, p. 41-45

Research output: Contribution to journalArticleAcademic