• 768 Citations
  • 11 h-Index
20102019
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Research Output 2010 2019

2019
9 Downloads (Pure)

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Apolipoproteins E
HDL Lipoproteins
Agglomeration
Apolipoprotein E4
Lipids
2 Citations (Scopus)

Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound

Vicidomini, C., Cioffi, F., Broersen, K., Roviello, V., Riccardi, C., Montesarchio, D., Capasso, D., Gaetano, S. D., Musumeci, D. & Roviello, G. N., 1 Feb 2019, In : Future Medicinal Chemistry. 11, 4, p. 285-302 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Circular Dichroism
Amyloid
Cell Aggregation
Fluorescence Spectrometry
Electron Scanning Microscopy

Investigation into the molecular complexity of Alzheimer's disease: an amyloid-ß centered approach

Cioffi, F., 20 Sep 2019, Enschede: University of Twente. 320 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

Amyloid
Alzheimer Disease
Interferon-gamma
Oxidative Stress
Research
2018
2 Citations (Scopus)

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

Gera, J., Szögi, T., Bozsó, Z., Fülöp, L., Barrera, E. E., Rodriguez, A. M., Méndez, L., Delpiccolo, C. M. L., Mata, E. G., Cioffi, F., Broersen, K., Paragi, G. & Enriz, R. D., 1 Dec 2018, In : Bioorganic Chemistry. 81, p. 211-221 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Dynamics Simulation
Amyloid
Alzheimer Disease
Agglomeration
Monomers
1 Citation (Scopus)

Structural and aggregation properties of Alpha-Synuclein linked to phospholipase A2 action

Broersen, K., Ruipérez, V. & Davletov, B., 1 Jan 2018, In : Protein and Peptide Letters. 25, 4, p. 368-378 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

alpha-Synuclein
Phospholipases A2
Arachidonic Acid
Agglomeration
Phosphatidylcholines
2017
18 Citations (Scopus)
40 Downloads (Pure)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 29 Mar 2017, In : PLoS ONE. 12, 3, 0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
11 Citations (Scopus)
32 Downloads (Pure)

The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein

Ruzafa, D., Hernandez-Gomez, Y. S., Bisello, G., Broersen, K., Morel, B. & Conejero-Lara, F., 31 May 2017, In : PLoS ONE. 12, 5, e0178576.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Acetylation
Parkinson disease
Micelles
acetylation
2016
6 Citations (Scopus)

Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states

Hubin, E., Cioffi, F., Rozenski, J., Van Nuland, N. A. J. & Broersen, K., 1 Jun 2016, In : Biochimica et biophysica acta. General subjects. 1860, 6, p. 1281-1290 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Insulysin
Agglomeration
Enzyme activity
Alzheimer Disease
Amyloid beta-Peptides
2 Citations (Scopus)

Could ecosystem management provide a new framework for Alzheimer's disease?

Hubin, E., Vanschoenwinkel, B., Broersen, K., de Deyn, P. P., Koedam, N., van Nuland, N. & Pauwels, K., 1 Sep 2016, In : Alzheimer's & dementia. 12, 1, p. 65-74 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ecosystem
Alzheimer Disease
Amyloid beta-Peptides
Brain Diseases
Complex Mixtures
2015

Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation stages

Hubin, E., Cioffi, F., Rozenski, J., van Nuland, N. & Broersen, K., 28 Sep 2015, p. -.

Research output: Contribution to conferencePosterOther research output

13 Citations (Scopus)

New mimetic peptides inhibitors of Aβ aggregation: Molecular guidance for rational drug design

Barrera Guisasola, E. E., Andujar, S., Hubin, E., Broersen, K., Kraan, Y. M., Mendez, L., Delpiccolo, C. M. L., Masman, M. F., Rodriguez, A. M. & Enriz, R. D., 2015, In : European journal of medicinal chemistry. 95, p. 136-152 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Design
Molecular Dynamics Simulation
Agglomeration
Peptides
Transmission Electron Microscopy

Structural and immunogenic characterization of differently organized bovine Beta-lactoglobulin aggregates

Verhoek, I., Teodorowicz, G., Wichers, H. & Broersen, K., 29 Sep 2015, p. -.

Research output: Contribution to conferencePosterOther research output

Studying the blood-brain barrier on a microfluidic chip

McKim, J. M. (ed.), van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2015.

Research output: Contribution to conferencePaperAcademic

36 Downloads (Pure)

Studying the blood-brain barrier on a microfluidic chip

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., Dec 2015, p. 313-314. 2 p.

Research output: Contribution to conferenceAbstractOther research output

File

Studying the blood-brain barrier on a microfluidic chip for drug development, pathology and toxicology

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 10 Nov 2015, p. -.

Research output: Contribution to conferencePosterOther research output

The multifactorial character of Alzheimer's disease

Cioffi, F., Rodriguez, A. M., Masman, M. F., Enriz, R. D. & Broersen, K., 3 Jun 2015, p. -.

Research output: Contribution to conferencePosterOther research output

10 Citations (Scopus)
26 Downloads (Pure)

Two distinct ß-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

Hubin, E., Deroo, S., Schierle, G. K., Kaminski, C., Serpell, L., Subramaniam, V., Van Nuland, N., Broersen, K., Raussens, V. & Sarroukh, R., 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4899-4913

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Amyloid
Alzheimer Disease
Cerebral Amyloid Angiopathy
Phenotype
Mutation
2014

Alzheimer's disease and cerebral amyloid angiopathy, doppelgangers?

Sarroukh, R., Hubin, E., Serpell, L. C., van Nuland, N., Broersen, K. & Raussens, V., 27 Jul 2014, p. 86-.

Research output: Contribution to conferenceAbstractOther research output

78 Downloads (Pure)

Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregation

Hubin, E., 24 Oct 2014, Enschede: Universiteit Twente. 158 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

File
Amyloid beta-Peptides
Alzheimer Disease
Amyloid
Neurodegenerative Diseases
Insulysin
30 Citations (Scopus)

Mechanistic insights in glycation-induced protein aggregation

Adrover, M., Marino, L., Sanchis, P., Pauwels, K., Kraan, Y. M., Lebrun, P., Vilanova, B., Munoz, F., Broersen, K. & Donoso, J., 2014, In : Biomacromolecules. 15, 9, p. 3449-3462 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

New mimetic peptide inhibitors of Abeta-aggregation. Molecular guidance for rational drug design

Barrera, E., Salcedo, R., Hubin, E., Broersen, K., Andujar, S. & Rodriguez, E. R., 5 Oct 2014, p. -.

Research output: Contribution to conferencePosterOther research output

58 Citations (Scopus)
23 Downloads (Pure)

Transient dynamics of Abeta contribute to toxicity in Alzheimer's disease

Hubin, E., van Nuland, N. A. J., Broersen, K. & Pauwels, K., 2014, In : Cellular and Molecular Life Sciences. 71, 18, p. 3507-3521

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alzheimer Disease
Peptides
Poisons
Amyloid
Cell Death
2013

Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils

Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N. & Broersen, K., 10 Oct 2013, p. -.

Research output: Contribution to conferencePosterOther research output

Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils

Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N. & Broersen, K., 16 Sep 2013, p. -.

Research output: Contribution to conferencePosterOther research output

2012
36 Citations (Scopus)

A comparative analysis of the aggregation behavior of amyloid-beta peptide variants

Vandersteen, A., Hubin, E., Sarroukh, R., de Baets, G., Schymkowitz, J., Rousseau, F., Subramaniam, V., Raussens, V., Wenschuh, H., Wildemann, D. & Broersen, K., 24 Oct 2012, In : FEBS letters. 586, 23, p. 4088-4093

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta-Peptides
Agglomeration
Amyloid
Peptides
Alzheimer Disease
79 Downloads (Pure)

Aggregation and toxicity of amyloid-beta peptide in relation to peptide sequence variation

Vandersteen, A., 12 Dec 2012, Enschede: Universiteit Twente. 180 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

File
Amyloid beta-Peptides
Toxicity
Protein Isoforms
Agglomeration
Peptides

Effect of ApoE isoform and lipidation status on proteolytic clearance of Amyloid-beta peptide

Hubin, E., Rozenski, J., De Strooper, B., Subramaniam, V., van Nuland, N. & Broersen, K., 26 Feb 2012, p. -.

Research output: Contribution to conferencePosterOther research output

Effect of ApoE isoform and lipidation status on proteolytic clearance of the Amyloid-beta peptide

Hubin, E., Rozenski, J., Subramaniam, V., van Nuland, N. & Broersen, K., 28 Mar 2012, p. -.

Research output: Contribution to conferencePosterOther research output

22 Citations (Scopus)

Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool

Vandersteen, A., Masman, M. F., de Baets, G., Jonckheere, W., van der Werf, K., Marrink, S. J., Rozenski, J., Benilova, I., De Strooper, B., Subramaniam, V., Schymkowitz, J., Rousseau, F. & Broersen, K., 19 Sep 2012, In : Journal of biological chemistry. 287, 44, p. 36732-36743 36732.

Research output: Contribution to journalArticleAcademicpeer-review

Oligomerization
Cytotoxicity
Plasticity
Toxicity
Amyloid Precursor Protein Secretases
126 Citations (Scopus)

The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease

Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L. C. & Broersen, K., 2012, In : Journal of biological chemistry. 287, p. 5650-5660

Research output: Contribution to journalArticleAcademicpeer-review

2011
68 Citations (Scopus)
1 Downloads (Pure)

Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation

Zhou, L., Brouwers, N., Benilova, I., Vandersteen, A., Mercken, M., van Laere, K., van Damme, P., Demedts, D., van Leuven, F., Sleegers, K., Broersen, K., van Broeckhoven, C., Vandenberghe, R. & De Strooper, B., 2011, In : EMBO molecular medicine. 3, 5, p. 291-302 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Mutation
Alzheimer Disease
Amyloid

Application potential of food protein modification

Broersen, K. & de Jongh, H. J., 2011, Chemical Engineering. Zeeshan Nawaz & Shahid Naveed (eds.). p. -

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

60 Citations (Scopus)

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

Broersen, K., Jonckheere, W., Rozenski, J., Vandersteen, A., Vandersteen, A., Pauwels, K., Pastore, A., Rousseau, F. & Schymkowitz, J., 2011, In : Protein engineering design & selection. 24, 9, p. 743-750 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biophysical consideration of gamma secretase modulation as potential target for Alzheimer's disease. Consequences of amyloid-beta peptide lenght variation

Vandersteen, A., Benilova, I., Jonckheere, W., de Baets, G., Rozenski, J., De Strooper, B., Subramaniam, V., Schymkowitz, J., Rousseau, F. & Broersen, K., 3 Oct 2011, p. -.

Research output: Contribution to conferencePosterOther research output

Biophysical consideration of g-secretase modulation as potential target for Alzheimer's disease

Vandersteen, A., Benilova, I., Jonckheere, W., Rousseau, F., Schymkowitz, J. & Broersen, K., 23 Aug 2011, p. -.

Research output: Contribution to conferencePosterOther research output

Biophysical consideration of g-secretase modulation as potential target for Alzheimer's disease

Vandersteen, A., Benilova, I., Jonckheere, W., Rousseau, F., Schymkowitz, J. & Broersen, K., 27 Sep 2011, p. -.

Research output: Contribution to conferencePosterOther research output

Effect of apoE isoform and lipidation status on proteolytic clearance of Amyloid-beta peptide

Hubin, E., Subramaniam, V., van Nuland, N. & Broersen, K., 23 Aug 2011, p. -.

Research output: Contribution to conferencePosterOther research output

Effect of ApoE isoform and lipidation status on proteolytic clearance of the Amyloid-beta peptide

Hubin, E., Subramaniam, V., van Nuland, N. & Broersen, K., 3 Oct 2011, p. -.

Research output: Contribution to conferencePosterOther research output

Risk factor for Alzheimers's disease: Pathological ABETA 40/42 ratio facilitates formation of stable neurotoxic oligomers

Broersen, K., Benilova, I., Kuperstein, I., Vandersteen, A., Jonckheere, W., Rozenski, J., Segers-Nolten, G. M. J., Subramaniam, V., d'Hooge, R., De Strooper, B. & Schymkowitz, J., 3 Oct 2011, p. -.

Research output: Contribution to conferencePosterOther research output

2010
303 Citations (Scopus)
16 Downloads (Pure)

Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta(42) to Abeta(40) ratio

Kuperstein, I., Broersen, K., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Segers-Nolten, G. M. J., van der Werf, K., Vandersteen, A. & Subramaniam, V., 2010, In : EMBO journal. 29, 19, p. 3408-3420 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

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