Kerensa Broersen

dr.

  • 801 Citations
  • 11 h-Index
20102019

Research output per year

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Research Output

2019

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
24 Downloads (Pure)

Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound

Vicidomini, C., Cioffi, F., Broersen, K., Roviello, V., Riccardi, C., Montesarchio, D., Capasso, D., Gaetano, S. D., Musumeci, D. & Roviello, G. N., 1 Feb 2019, In : Future Medicinal Chemistry. 11, 4, p. 285-302 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Cioffi, F., Adam, R. H. I. & Broersen, K., 12 Dec 2019, In : Journal of Alzheimer's Disease. 72, 4, p. 981-1017 37 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
7 Downloads (Pure)

Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function

Zakharova, M., van der Helm, M., Palma Do Carmo, M., Le The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L., 2019.

Research output: Contribution to conferencePoster

2018

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

Gera, J., Szögi, T., Bozsó, Z., Fülöp, L., Barrera, E. E., Rodriguez, A. M., Méndez, L., Delpiccolo, C. M. L., Mata, E. G., Cioffi, F., Broersen, K., Paragi, G. & Enriz, R. D., 1 Dec 2018, In : Bioorganic Chemistry. 81, p. 211-221 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Structural and aggregation properties of Alpha-Synuclein linked to phospholipase A2 action

Broersen, K., Ruipérez, V. & Davletov, B., 1 Jan 2018, In : Protein and Peptide Letters. 25, 4, p. 368-378 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2017

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 29 Mar 2017, In : PLoS ONE. 12, 3, 0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
20 Citations (Scopus)
53 Downloads (Pure)

The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein

Ruzafa, D., Hernandez-Gomez, Y. S., Bisello, G., Broersen, K., Morel, B. & Conejero-Lara, F., 31 May 2017, In : PLoS ONE. 12, 5, e0178576.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
12 Citations (Scopus)
42 Downloads (Pure)
2016

Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states

Hubin, E., Cioffi, F., Rozenski, J., Van Nuland, N. A. J. & Broersen, K., 1 Jun 2016, In : Biochimica et biophysica acta. General subjects. 1860, 6, p. 1281-1290 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Could ecosystem management provide a new framework for Alzheimer's disease?

Hubin, E., Vanschoenwinkel, B., Broersen, K., de Deyn, P. P., Koedam, N., van Nuland, N. & Pauwels, K., 1 Sep 2016, In : Alzheimer's & dementia. 12, 1, p. 65-74 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2015

Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation stages

Hubin, E., Cioffi, F., Rozenski, J., van Nuland, N. & Broersen, K., 28 Sep 2015, p. -.

Research output: Contribution to conferencePoster

New mimetic peptides inhibitors of Aβ aggregation: Molecular guidance for rational drug design

Barrera Guisasola, E. E., Andujar, S., Hubin, E., Broersen, K., Kraan, Y. M., Mendez, L., Delpiccolo, C. M. L., Masman, M. F., Rodriguez, A. M. & Enriz, R. D., 2015, In : European journal of medicinal chemistry. 95, p. 136-152 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Structural and immunogenic characterization of differently organized bovine Beta-lactoglobulin aggregates

Verhoek, I., Teodorowicz, G., Wichers, H. & Broersen, K., 29 Sep 2015, p. -.

Research output: Contribution to conferencePoster

Studying the blood-brain barrier on a microfluidic chip

McKim, J. M. (ed.), van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., 2015.

Research output: Contribution to conferencePaper

Studying the blood-brain barrier on a microfluidic chip

van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I., Dec 2015, p. 313-314. 2 p.

Research output: Contribution to conferenceAbstract

File
44 Downloads (Pure)

The multifactorial character of Alzheimer's disease

Cioffi, F., Rodriguez, A. M., Masman, M. F., Enriz, R. D. & Broersen, K., 3 Jun 2015, p. -.

Research output: Contribution to conferencePoster

Two distinct ß-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

Hubin, E., Deroo, S., Schierle, G. K., Kaminski, C., Serpell, L., Subramaniam, V., Van Nuland, N., Broersen, K., Raussens, V. & Sarroukh, R., 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4899-4913

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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11 Citations (Scopus)
36 Downloads (Pure)
2014

Alzheimer's disease and cerebral amyloid angiopathy, doppelgangers?

Sarroukh, R., Hubin, E., Serpell, L. C., van Nuland, N., Broersen, K. & Raussens, V., 27 Jul 2014, p. 86-.

Research output: Contribution to conferenceAbstract

Mechanistic insights in glycation-induced protein aggregation

Adrover, M., Marino, L., Sanchis, P., Pauwels, K., Kraan, Y. M., Lebrun, P., Vilanova, B., Munoz, F., Broersen, K. & Donoso, J., 2014, In : Biomacromolecules. 15, 9, p. 3449-3462 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

New mimetic peptide inhibitors of Abeta-aggregation. Molecular guidance for rational drug design

Barrera, E., Salcedo, R., Hubin, E., Broersen, K., Andujar, S. & Rodriguez, E. R., 5 Oct 2014, p. -.

Research output: Contribution to conferencePoster

Transient dynamics of Abeta contribute to toxicity in Alzheimer's disease

Hubin, E., van Nuland, N. A. J., Broersen, K. & Pauwels, K., 2014, In : Cellular and Molecular Life Sciences. 71, 18, p. 3507-3521

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
63 Citations (Scopus)
45 Downloads (Pure)
2013

Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils

Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N. & Broersen, K., 10 Oct 2013, p. -.

Research output: Contribution to conferencePoster

Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils

Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N. & Broersen, K., 16 Sep 2013, p. -.

Research output: Contribution to conferencePoster

2012

A comparative analysis of the aggregation behavior of amyloid-beta peptide variants

Vandersteen, A., Hubin, E., Sarroukh, R., de Baets, G., Schymkowitz, J., Rousseau, F., Subramaniam, V., Raussens, V., Wenschuh, H., Wildemann, D. & Broersen, K., 24 Oct 2012, In : FEBS letters. 586, 23, p. 4088-4093

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Effect of ApoE isoform and lipidation status on proteolytic clearance of Amyloid-beta peptide

Hubin, E., Rozenski, J., De Strooper, B., Subramaniam, V., van Nuland, N. & Broersen, K., 26 Feb 2012, p. -.

Research output: Contribution to conferencePoster

Effect of ApoE isoform and lipidation status on proteolytic clearance of the Amyloid-beta peptide

Hubin, E., Rozenski, J., Subramaniam, V., van Nuland, N. & Broersen, K., 28 Mar 2012, p. -.

Research output: Contribution to conferencePoster

Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool

Vandersteen, A., Masman, M. F., de Baets, G., Jonckheere, W., van der Werf, K., Marrink, S. J., Rozenski, J., Benilova, I., De Strooper, B., Subramaniam, V., Schymkowitz, J., Rousseau, F. & Broersen, K., 19 Sep 2012, In : Journal of biological chemistry. 287, 44, p. 36732-36743 36732.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease

Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L. C. & Broersen, K., 2012, In : Journal of biological chemistry. 287, p. 5650-5660

Research output: Contribution to journalArticleAcademicpeer-review

130 Citations (Scopus)
2011

Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation

Zhou, L., Brouwers, N., Benilova, I., Vandersteen, A., Mercken, M., van Laere, K., van Damme, P., Demedts, D., van Leuven, F., Sleegers, K., Broersen, K., van Broeckhoven, C., Vandenberghe, R. & De Strooper, B., 2011, In : EMBO molecular medicine. 3, 5, p. 291-302 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
68 Citations (Scopus)
12 Downloads (Pure)

Application potential of food protein modification

Broersen, K. & de Jongh, H. J., 2011, Chemical Engineering. Zeeshan Nawaz & Shahid Naveed (eds.). p. -

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

Broersen, K., Jonckheere, W., Rozenski, J., Vandersteen, A., Vandersteen, A., Pauwels, K., Pastore, A., Rousseau, F. & Schymkowitz, J., 2011, In : Protein engineering design & selection. 24, 9, p. 743-750 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Biophysical consideration of gamma secretase modulation as potential target for Alzheimer's disease. Consequences of amyloid-beta peptide lenght variation

Vandersteen, A., Benilova, I., Jonckheere, W., de Baets, G., Rozenski, J., De Strooper, B., Subramaniam, V., Schymkowitz, J., Rousseau, F. & Broersen, K., 3 Oct 2011, p. -.

Research output: Contribution to conferencePoster

Biophysical consideration of g-secretase modulation as potential target for Alzheimer's disease

Vandersteen, A., Benilova, I., Jonckheere, W., Rousseau, F., Schymkowitz, J. & Broersen, K., 23 Aug 2011, p. -.

Research output: Contribution to conferencePoster

Biophysical consideration of g-secretase modulation as potential target for Alzheimer's disease

Vandersteen, A., Benilova, I., Jonckheere, W., Rousseau, F., Schymkowitz, J. & Broersen, K., 27 Sep 2011, p. -.

Research output: Contribution to conferencePoster

Effect of apoE isoform and lipidation status on proteolytic clearance of Amyloid-beta peptide

Hubin, E., Subramaniam, V., van Nuland, N. & Broersen, K., 23 Aug 2011, p. -.

Research output: Contribution to conferencePoster

Effect of ApoE isoform and lipidation status on proteolytic clearance of the Amyloid-beta peptide

Hubin, E., Subramaniam, V., van Nuland, N. & Broersen, K., 3 Oct 2011, p. -.

Research output: Contribution to conferencePoster

Risk factor for Alzheimers's disease: Pathological ABETA 40/42 ratio facilitates formation of stable neurotoxic oligomers

Broersen, K., Benilova, I., Kuperstein, I., Vandersteen, A., Jonckheere, W., Rozenski, J., Segers-Nolten, G. M. J., Subramaniam, V., d'Hooge, R., De Strooper, B. & Schymkowitz, J., 3 Oct 2011, p. -.

Research output: Contribution to conferencePoster

2010

Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta(42) to Abeta(40) ratio

Kuperstein, I., Broersen, K., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Segers-Nolten, G. M. J., van der Werf, K., Vandersteen, A. & Subramaniam, V., 2010, In : EMBO journal. 29, 19, p. 3408-3420 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

File
311 Citations (Scopus)
24 Downloads (Pure)