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20102019
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Research Output 2010 2019

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Article
2019
11 Downloads (Pure)

Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation

Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K., 1 Jun 2019, In : FEBS letters. 593, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Apolipoproteins E
HDL Lipoproteins
Agglomeration
Apolipoprotein E4
Lipids
2 Citations (Scopus)

Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound

Vicidomini, C., Cioffi, F., Broersen, K., Roviello, V., Riccardi, C., Montesarchio, D., Capasso, D., Gaetano, S. D., Musumeci, D. & Roviello, G. N., 1 Feb 2019, In : Future Medicinal Chemistry. 11, 4, p. 285-302 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Circular Dichroism
Amyloid
Cell Aggregation
Fluorescence Spectrometry
Electron Scanning Microscopy
2018
2 Citations (Scopus)

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

Gera, J., Szögi, T., Bozsó, Z., Fülöp, L., Barrera, E. E., Rodriguez, A. M., Méndez, L., Delpiccolo, C. M. L., Mata, E. G., Cioffi, F., Broersen, K., Paragi, G. & Enriz, R. D., 1 Dec 2018, In : Bioorganic Chemistry. 81, p. 211-221 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Molecular Dynamics Simulation
Amyloid
Alzheimer Disease
Agglomeration
Monomers
1 Citation (Scopus)

Structural and aggregation properties of Alpha-Synuclein linked to phospholipase A2 action

Broersen, K., Ruipérez, V. & Davletov, B., 1 Jan 2018, In : Protein and Peptide Letters. 25, 4, p. 368-378 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

alpha-Synuclein
Phospholipases A2
Arachidonic Acid
Agglomeration
Phosphatidylcholines
2017
18 Citations (Scopus)
42 Downloads (Pure)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 29 Mar 2017, In : PLoS ONE. 12, 3, 0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
11 Citations (Scopus)
35 Downloads (Pure)

The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein

Ruzafa, D., Hernandez-Gomez, Y. S., Bisello, G., Broersen, K., Morel, B. & Conejero-Lara, F., 31 May 2017, In : PLoS ONE. 12, 5, e0178576.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Acetylation
Parkinson disease
Micelles
acetylation
2016
6 Citations (Scopus)

Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states

Hubin, E., Cioffi, F., Rozenski, J., Van Nuland, N. A. J. & Broersen, K., 1 Jun 2016, In : Biochimica et biophysica acta. General subjects. 1860, 6, p. 1281-1290 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Insulysin
Agglomeration
Enzyme activity
Alzheimer Disease
Amyloid beta-Peptides
2 Citations (Scopus)

Could ecosystem management provide a new framework for Alzheimer's disease?

Hubin, E., Vanschoenwinkel, B., Broersen, K., de Deyn, P. P., Koedam, N., van Nuland, N. & Pauwels, K., 1 Sep 2016, In : Alzheimer's & dementia. 12, 1, p. 65-74 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ecosystem
Alzheimer Disease
Amyloid beta-Peptides
Brain Diseases
Complex Mixtures
2015
13 Citations (Scopus)

New mimetic peptides inhibitors of Aβ aggregation: Molecular guidance for rational drug design

Barrera Guisasola, E. E., Andujar, S., Hubin, E., Broersen, K., Kraan, Y. M., Mendez, L., Delpiccolo, C. M. L., Masman, M. F., Rodriguez, A. M. & Enriz, R. D., 2015, In : European journal of medicinal chemistry. 95, p. 136-152 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Drug Design
Molecular Dynamics Simulation
Agglomeration
Peptides
Transmission Electron Microscopy
10 Citations (Scopus)
26 Downloads (Pure)

Two distinct ß-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

Hubin, E., Deroo, S., Schierle, G. K., Kaminski, C., Serpell, L., Subramaniam, V., Van Nuland, N., Broersen, K., Raussens, V. & Sarroukh, R., 2015, In : Cellular and Molecular Life Sciences. 72, 24, p. 4899-4913

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Amyloid
Alzheimer Disease
Cerebral Amyloid Angiopathy
Phenotype
Mutation
2014
30 Citations (Scopus)

Mechanistic insights in glycation-induced protein aggregation

Adrover, M., Marino, L., Sanchis, P., Pauwels, K., Kraan, Y. M., Lebrun, P., Vilanova, B., Munoz, F., Broersen, K. & Donoso, J., 2014, In : Biomacromolecules. 15, 9, p. 3449-3462 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)
24 Downloads (Pure)

Transient dynamics of Abeta contribute to toxicity in Alzheimer's disease

Hubin, E., van Nuland, N. A. J., Broersen, K. & Pauwels, K., 2014, In : Cellular and Molecular Life Sciences. 71, 18, p. 3507-3521

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Alzheimer Disease
Peptides
Poisons
Amyloid
Cell Death
2012
36 Citations (Scopus)

A comparative analysis of the aggregation behavior of amyloid-beta peptide variants

Vandersteen, A., Hubin, E., Sarroukh, R., de Baets, G., Schymkowitz, J., Rousseau, F., Subramaniam, V., Raussens, V., Wenschuh, H., Wildemann, D. & Broersen, K., 24 Oct 2012, In : FEBS letters. 586, 23, p. 4088-4093

Research output: Contribution to journalArticleAcademicpeer-review

Amyloid beta-Peptides
Agglomeration
Amyloid
Peptides
Alzheimer Disease
22 Citations (Scopus)

Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool

Vandersteen, A., Masman, M. F., de Baets, G., Jonckheere, W., van der Werf, K., Marrink, S. J., Rozenski, J., Benilova, I., De Strooper, B., Subramaniam, V., Schymkowitz, J., Rousseau, F. & Broersen, K., 19 Sep 2012, In : Journal of biological chemistry. 287, 44, p. 36732-36743 36732.

Research output: Contribution to journalArticleAcademicpeer-review

Oligomerization
Cytotoxicity
Plasticity
Toxicity
Amyloid Precursor Protein Secretases
126 Citations (Scopus)

The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease

Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L. C. & Broersen, K., 2012, In : Journal of biological chemistry. 287, p. 5650-5660

Research output: Contribution to journalArticleAcademicpeer-review

2011
68 Citations (Scopus)
2 Downloads (Pure)

Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation

Zhou, L., Brouwers, N., Benilova, I., Vandersteen, A., Mercken, M., van Laere, K., van Damme, P., Demedts, D., van Leuven, F., Sleegers, K., Broersen, K., van Broeckhoven, C., Vandenberghe, R. & De Strooper, B., 2011, In : EMBO molecular medicine. 3, 5, p. 291-302 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Mutation
Alzheimer Disease
Amyloid
60 Citations (Scopus)

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

Broersen, K., Jonckheere, W., Rozenski, J., Vandersteen, A., Vandersteen, A., Pauwels, K., Pastore, A., Rousseau, F. & Schymkowitz, J., 2011, In : Protein engineering design & selection. 24, 9, p. 743-750 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010
303 Citations (Scopus)
17 Downloads (Pure)

Neurotoxicity of Alzheimer's disease Abeta peptides is induced by small changes in the Abeta(42) to Abeta(40) ratio

Kuperstein, I., Broersen, K., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Segers-Nolten, G. M. J., van der Werf, K., Vandersteen, A. & Subramaniam, V., 2010, In : EMBO journal. 29, 19, p. 3408-3420 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

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