Leon Terstappen

Research output

Research output per year 1985 2004 2006 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2025

• 197 Article
• 68 Poster
• 47 Patent
• 16 Conference contribution
• 57 More
  • 13 Chapter
  • 12 Meeting Abstract
  • 9 Paper
  • 5 Abstract
  • 5 Comment/Letter to the editor
  • 5 Review article
  • 3 Other contribution
  • 1 Inaugural speech
  • 1 Conference article
  • 1 Editorial
  • 1 Web publication/site
  • 1 PhD Thesis - Research UT, graduation UT

Research output per year

Research output per year

Search results

• 2010

  CTC classification with the Cellsearch system

  Terstappen, L. W. M. M., 3 Nov 2010, Virtual Meeting Presentation and Live Q & A

  Research output: Other contribution › Other research output

• Detecteren en karakteriseren van kankercellen in bloed

  Terstappen, L. W. M. M., 11 Nov 2010, p. -.

  Research output: Contribution to conference › Paper

• Development of automatic FISH probe counting in CTC

  Ligthart, S. T., Swennenhuis, J. F., Greve, J. & Terstappen, L. W. M. M., 19 Apr 2010.

  Research output: Contribution to conference › Poster › Other research output

  • Fluorescence in Situ Hybridization 100%
  • Circulating Tumor Cell 100%
  • Hybridization Probe 100%
  • Chromosome 1 50%
  • Leukocyte 37%

• Hybrid imaging of gold nanorods on breast cancer cells

  Hartsuiker, L., van Es, P., Petersen, W., Manohar, S., van Leeuwen, T., van Apeldoorn, A. A., Poot, A. A., Terstappen, L. W. M. M. & Otto, C., 4 Oct 2010. 1 p.

  Research output: Contribution to conference › Poster › Other research output

• Magnetic separation apparatus and methods

  Tibbe, A. G. J. (Inventor), Terstappen, L. W. M. M. (Inventor) & Scholtens, T. M. (Inventor), 23 Feb 2010, (Submitted) Patent No. 7,666,308 B2, Priority date 23 Feb 2010

  Research output: Patent

  File

  • Magnetism 100%
  • Surface Property 50%
  • Quantitative Technique 50%
  • Sample Preparation 50%
  • Liquid 50%
  129 Downloads (Pure)

• Method and apparatus from imaging target components in a biological sample using permanent magnets

  Tibbe, A. G. J. (Inventor) & Terstappen, L. W. M. M. (Inventor), 9 Nov 2010, (Submitted) Patent No. 7,828,968 B2, Priority date 9 Nov 2010

  Research output: Patent

  File

  • Targets 100%
  • Magnet 100%
  • Sample 100%
  • Magnets 80%
  • Blood 80%
  134 Downloads (Pure)

• Methods and Algorithms for cell enumeration in low-cost cytometer

  Coumans, F. A. W. (Inventor), Greve, J. (Inventor), Modica, F. P. (Inventor), Terstappen, L. W. M. M. (Inventor), Tibbe, A. G. J. (Inventor) & Verrant, J. A. (Inventor), 27 Jul 2010, (Submitted) Patent No. US 7,764,821 B2, Priority date 27 Jul 2010

  Research output: Patent

  File

  • Algorithms 100%
  • Low Cost 100%
  • Enumeration 100%
  • Sample 100%
  • Targets 100%
  124 Downloads (Pure)

• Raman spectroscopy and imaging of gold nanoparticles with cells

  Hartsuiker, L., Rayavarapu, R. G., Petersen, W., van Leeuwen, T., Terstappen, L. W. M. M., Manohar, S. & Otto, C., 31 Mar 2010.

  Research output: Contribution to conference › Poster › Other research output

• Significance of Circulating Tumor Cells detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer

  Miller, M. C., Doyle, G. V. & Terstappen, L. W. M. M., 2010, In: Journal of oncology. 2010, p. 1-8 8 p., 617421.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  96 Downloads (Pure)

• Significant and Sustained Antitumor Activity in Post-Docetaxel, Castration-Resistant Prostate Cancer With the CYP17 Inhibitor Abiraterone Acetate

  Reid, A. H. M., Attard, G., Danila, D. C., Oommen, N. B., Olmos, D., Fong, P. C., Molife, L. R., Hunt, J., Messiou, C., Parker, C., Dearnaley, D., Swennenhuis, J. F., Terstappen, L. W. M. M., Lee, G., Kheoh, T., Molina, A., Ryan, C. J., Small, E., Scher, H. I. & de Bono, J. S., 2010, In: Journal of clinical oncology. 28, 9, p. 1489-1495

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Abiraterone Acetate 100%
  • Cytochrome P450 Family 17 100%
  364 Citations (Scopus)

  134 Downloads (Pure)
• 2009

  CD4 and CD8 Enumeration for HIV Monitoring in Resource-Constrained Settings

  Li, X., Breukers, C., Ymeti, A., Lunter, B., Terstappen, L. W. M. M. & Greve, J., 2009, In: Cytometry. Part B : Clinical cytometry. 76B, p. 118-126 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  9 Citations (Scopus)

• Characterization of Circulating Tumor Cells by Fluorescence In-Situ Hybridization

  Swennenhuis, J. F., Tibbe, A. G. J., Levink, R., Terstappen, L. W. M. M. & Sipkema, R. C. J., 2009, In: Cytometry. Part A. 75A, 6, p. 520-527 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  104 Citations (Scopus)

  5 Downloads (Pure)

• Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer

  Attard, G., Swennenhuis, J. F., Olmos, D., Reid, A. H. M., Vickers, E., A'Hern, R., Levink, R., Coumans, F., Moreira, J., Riisnaes, R., Oommen, N. B., Hawche, G., Jameson, C., Thompson, E., Sipkema, R., Carden, C. P., Parker, C., Dearnaley, D., Kaye, S. B. & Cooper, C. S. & 4 others, Molina, A., Cox, M. E., Terstappen, L. W. M. M. & De Bono, J. S., 2009, In: Cancer research. 69, 7, p. 2912-2918

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • PTEN (Gene) 100%
  • Cell Adhesion Molecule 50%
  • Carcinogenesis 50%
  489 Citations (Scopus)

  52 Downloads (Pure)

• Circulating Tumor Cells (CTC) as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience

  Olmos, D., Arkenau, H. T., Ang, J. E., Ledaki, I., Attard, G., Carden, C. P., Reid, A. H. M., Hem, R. A., Fong, P. C., Oomen, N. B., Molife, R., Dearnaley, D., Parker, C., Terstappen, L. W. M. M. & de Bono, J. S., 2009, In: Annals of oncology. 20, p. 27-37 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  224 Citations (Scopus)

• Circulating tumour cells early predict progression-free and overall survivalin advanced colorectal cancer patients treated with chemotherapy and targeted agents

  Tol, J., Miller, M. C., Tibbe, A. G. J., Cats, A., Creemers, G. J. M., Vos, A. H., Nagtegaal, I. D., Terstappen, L. W. M. M. & Punt, C. J. A., 2009, In: Annals of oncology. p. 463- 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Commentary the molecular characterization of 19 breast cancer cell lines by Sieuwerts et al.

  Connelly, M. C., Wang, Y., Doyle, G. V., Terstappen, L. W. M. M. & McCormack, R., 2009, In: Journal of the National Cancer Institute. 101, p. 895- 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Prognostic Significance of Circulating Tumor Cells in Patients with Metastatic Colorectal Cancer

  Cohen, S. J., Punt, C. J. A., Iannotti, N., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M., Mitchell, E., Miller, M. C., Doyle, G. V., Tissing, H., Terstappen, L. W. M. M. & Meropol, N. J., 2009, In: Annals of oncology. 20, p. 1223-1229 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  448 Citations (Scopus)

• Quantitative analysis of circulating tumor cells as a survival predictor in metastatic castration-resistant prostate cancer: Missing parts in a superb study

  De Bono, J. S., Parker, C., Scher, H. I., Montgomery, R. B., Miller, M. C., Tissing, H., Doyle, G. V., Terstappen, L. W. W. M., Pienta, K. J. & Raghavan, D., 2009, In: Clinical cancer research. 15, 4, p. 1504-1505

  Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
  3 Citations (Scopus)

• Re: Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells

  Connelly, M., Wang, Y., Doyle, G. V., Terstappen, L. & McCormack, R., 2009, In: Journal of the National Cancer Institute. 101, 12, p. 895

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751, 871) in Combination with Paclitaxel and Carboplatin

  Karp, D. D., Pollak, M. N., Cohen, R. B., Eisenberg, P. D., Haluska, P., Yin, D., Lipton, A., Demers, L., Leitzel, K., Hixon, M. L., Terstappen, L. W. M. M., Garland, L., Paz-Ares, L. G., Cardenal, F. & Gualberto, A., 2009, In: Journal of thoracic oncology. 4, 11, p. 1397-1403

  Research output: Contribution to journal › Article › Academic › peer-review
  58 Citations (Scopus)
• 2008

  Automatic FISH probe counting: influence of deconvolution

  Ligthart, S., Swennenhuis, J. F., Greve, J. & Terstappen, L. W. M. M., 17 May 2008, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Automatic FISH probe counting in circulating tumor cells

  Ligthart, S., Swennenhuis, J. F., Sipkema, R. C. J., Tibbe, A. G. J., Greve, J. & Terstappen, L. W. M. M., 20 Nov 2008, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Characterization of circulating tumor cells by image cytometry

  Schreuder, F., Scholtens, T. M., Ligthart, S., Greve, J., Terstappen, L. W. M. M., Tibbe, A. G. J. & Swennenhuis, J. F., 17 May 2008, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Characterization of NSCLC patients responding to anti-IGF-IR therapy

  Gualberto, A., Melvin, C., Dean, A., Ang, A. L., Reynolds, J. M., Lee, A. V., Terstappen, L. W. M. M., Haluska, P., Lipton, A. & Karp, D. D., 2008, p. 8000-.

  Research output: Contribution to conference › Abstract › Other research output

• Circulating Tumor Cells (CTC) predict survival benefit from treatment in metastatic castration resistant prostate cancer (CRPC)

  de Bono, J. S., Scher, H. I., Montgomery, R. B., Parker, C., Miller, M. C., Tissing, H., Doyle, G. V., Terstappen, L. W. M. M., Pienta, K. J. & Raghavan, D., 2008, In: Clinical cancer research. 14, p. 6302-6309 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  1941 Citations (Scopus)

• Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial damage

  Strijbos, M. H., Rao, C., Schmitz, P. I. M., Kraan, J., Lamers, C. H., Sleijfer, S., Terstappen, L. W. M. M. & Gratama, J. W., 2008, In: Thrombosis and haemostasis. 100, 4, p. 642-647 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Thrombomodulin 100%
  • E-Selectin 60%
  • Endoglin 40%
  • CD146 14%
  • Multivariate Analysis 14%
  31 Citations (Scopus)

• Detection of Bcl-2 and apoptosis in circulating tumor cells during treatment of metastatic breast cancer

  Smerage, J. B., Doyle, G. V., Budd, G. T., Repollet, M., Miller, C., Terstappen, L. W. & Hayes, D. F., 2008, In: Journal of clinical oncology. 26, 15_suppl., 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

  Open Access

  • Programmed Cell Death 100%
  • Circulating Tumor Cell 100%
  • Therapeutic Procedure 100%
  • Metastatic Breast Cancer 100%
  • Apoptosis 100%

• Detection of Bcl-2 and apoptosis in circulating tumor cells during treatment of metastatic breast cancer

  Smerage, J. B., Doyle, G. V., Budd, G. T., Repollet, M. I., Miller, M. C., Terstappen, L. W. M. M. & Hayes, D. F., 2008. 1 p.

  Research output: Contribution to conference › Paper

• Diagnostics utility of multiparameter flow cytometry analysis in myelodysplastic syndromes

  Kemna, E., Koopman, H. F. J. M. (Editor), Slomp, J., Kanger, J. S. (Editor), Engbersen, J. F. J. (Editor), de Groot, M., Terstappen, L. W., Poot, A. A. & Vermes, I., 20 Nov 2008, p. 93-96.

  Research output: Contribution to conference › Paper

• Evaluation of image analysis algorithms for CD4 an CD8 enumeration in an automated image cytometer

  Breukers, C., Li, X., Ymeti, A., Greve, J., Terstappen, L. W. M. M., Pattanapanyasat, K. & Sukapirom, K., 17 May 2008, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Improved imaging of immunomagnetically enriched rare cells

  Scholtens, T. M., Schreuder, F., Greve, J., Tibbe, A. G. J. & Terstappen, L. W. M. M., 17 May 2008, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients with Metastatic Colorectal Cancer

  Cohen, S. J., Punt, C. J. A., Iannotti, N., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M., Mitchell, E., Miller, M. C., Doyle, G. V., Tissing, H., Terstappen, L. W. M. M. & Meropol, N. J., 2008, In: Journal of clinical oncology. 26, 19, p. 3213-3221 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Overall Survival 100%
  • Metastatic Colorectal Cancer 100%
  • Circulating Tumor Cell 100%
  • Progression Free Survival 100%
  • Neoplasm 100%
  1635 Citations (Scopus)

  627 Downloads (Pure)
• 2007

  An image cytometer for resource-poor settings to monitor disease progression in HIV infection

  Ymeti, A., Li, X., Lunter, B., Breukers, C., Tibbe, A. G. J., Terstappen, L. W. M. M. & Greve, J., 2007, In: Cytometry. Part A. A, 3, p. 132-142 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Human Immunodeficiency Virus Infection 100%
  • CD3 Antigen 100%
  • CD4 CD8 Ratio 60%
  • CD8+ T Lymphocyte 40%
  • Human immunodeficiency virus 40%
  29 Citations (Scopus)

  11 Downloads (Pure)

• An immunomagnetic single-platform image cytometer for cell enumeration based on antibody specificity

  Li, X., Tibbe, A. G. J., Droog, E., Terstappen, L. W. M. M. & Greve, J., 2007, In: Clinical and vaccine immunology. 14, 4, p. 412-419 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  12 Citations (Scopus)

  24 Downloads (Pure)

• CD4+T Lymphocytes enumeration by an easy-to-use single platform image cytometer for HIV monitoring in resource-constrained settings

  Li, X., Ymeti, A., Lunter, B., Breukers, C., Tibbe, A. G. J., Terstappen, L. W. M. M. & Greve, J., 2007, In: Cytometry. Part B : Clinical cytometry. 72B, 5, p. 397-407 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • T-Cells 100%
  • CD3 Antigen 33%
  • Surface Analysis 22%
  • Antibody Labeling 11%
  • Phycoerythrin 11%
  16 Citations (Scopus)

  7 Downloads (Pure)

• Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer

  Shaffer, D. R., Leversha, M. A., Danila, D. C., Lin, O., Gonzalez-Espinoza, R., Gu, B., Anand, A., Han, J., Smith, K., Maslak, P., Lilja, H., Doyle, G. V., Terstappen, L. W. M. M., Heller, G., Fleisher, M. & Scher, H. I., 2007, In: Clinical cancer research. 13, p. 2023-2029 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  319 Citations (Scopus)

• Devices and methods to image objects

  Tibbe, A. G. J. (Inventor), Greve, J. (Inventor), Terstappen, L. W. M. M. (Inventor) & de Grooth, B. G. (Inventor), 16 Oct 2007, Patent No. US 7,282,180 B2

  Research output: Patent

  File
  123 Downloads (Pure)

• Endothelial Cells in Peripheral Blood of Healthy Subjects and Patients with Metastatic Carcinomas

  Rowand, J. L., Martin, G., Doyle, G. V., Miller, M. C., Pierce, M. S., Connelly, M. C., Rao, C. & Terstappen, L. W. M. M., 2007, In: Cytometry. Part A. Part A 71A, p. 105-113 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Metastatic Carcinoma 100%
  • Patient 100%
  • Endothelial Cell 100%
  • Cell Count 42%
  • Cells 42%
  115 Citations (Scopus)

  3 Downloads (Pure)

• Kijken Denken Doen (Look Think Do)

  Terstappen, L. W. M. M., 28 Sept 2007, Enschede: University of Twente. 50 p.

  Research output: Book/Report › Inaugural speech › Other research output

  Open Access

  File
  81 Downloads (Pure)

• Physiological stress induces the metastasis marker AGR2 in breast cancer cells

  Zweitzig, D. R., Smirnov, D. A., Connelly, M. C., Terstappen, L. W. M. M., O'Hara, S. M. & Moran, E., 2007, In: Molecular and Cellular Biochemistry. 306, p. 255-260

  Research output: Contribution to journal › Article › Academic › peer-review

  • Physiological Stress 100%
  • Cell Marker 66%
  • Developmental Gene 33%
  • Gene Product 33%
  64 Citations (Scopus)

• Potential Applications for Circulating Tumor Cells expressing the Insulin Growth Factor-I Receptor

  de Bono, J. S., Attard, G., Adjei, A., Pollak, M. N., Fong, P. C., Haluska, P., Roberts, L., Melvin, C., Repollet, M., Chianese, D., Connely, M., Terstappen, L. W. M. M. & Gualberto, A., 2007, In: Clinical cancer research. 13, 12, p. 3611-3616 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Somatomedin 100%
  • Fibrinogen 100%
  • Patient 100%
  • Receptor 100%
  • Circulating Tumor Cell 100%
  179 Citations (Scopus)

  1 Downloads (Pure)

• Statistical considerations for enumeration of circulating tumor cells

  Tibbe, A. G. J., Miller, M. C. & Terstappen, L. W. M. M., 2007, In: Cytometry. Part A. 71A, 3, p. 154-162

  Research output: Contribution to journal › Article › Academic › peer-review

  • Blood Sampling 100%
  • Circulating Tumor Cell 100%
  • Neoplasm 100%
  • Poisson Distribution 50%
  • Survival 50%
  184 Citations (Scopus)
• 2006

  Affordable CD4 enumeration

  Ymeti, A., Li, X., Lunter, B., Breukers, C., Brinkers, S., Tibbe, A. G. J., Terstappen, L. W. M. M. & Greve, J., 13 Aug 2006, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Affordable Cell Enumeration for HIV Staging

  Li, X., Ymeti, A., Lunter, B., Breukers, C., Greve, J., Tibbe, A. G. J. & Terstappen, L. W. M. M., 20 May 2006, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Cell aligning microstructures for image cytometry

  Scholtens, T. M., Schreuder, F., Greve, J., Tibbe, A. G. J. & Terstappen, L. W. M. M., 9 Oct 2006, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival.

  Hayes, D. F., Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Miller, M. C., Matera, J., Allard, W. J., Doyle, G. V. & Terstappen, L. W., 2006, In: Clinical cancer research. 12, 14, p. 4218-4224

  Research output: Contribution to journal › Article › Academic › peer-review

  • Patient 100%
  • Overall Survival 100%
  • Circulating Tumor Cell 100%
  • Follow up 100%
  • Progression Free Survival 100%
  899 Citations (Scopus)

• Circulating tumor cells versus imaging - Predicting overall survival in metastatic breast cancer

  Budd, G. T., Cristofanilli, M., Ellis, M. J., Stopeck, A., Borden, E., Miller, M. C., Matera, J., Repollet, M., Doyle, G. V., Terstappen, L. W. M. M. & Hayes, D. F., 2006, In: Clinical cancer research. 12, 21, p. 6403-6409

  Research output: Contribution to journal › Article › Academic › peer-review

  • Overall Survival 100%
  • Circulating Tumor Cell 100%
  • Metastatic Breast Cancer 100%
  • Patient 80%
  • Combination Therapy 60%
  698 Citations (Scopus)

• Fast Tumor Cell Detection by scanning for Chromosomal Aberrations

  Ligthart, S., Schreuder, F., Greve, J., Terstappen, L. W. M. M. & Tibbe, A. G. J., 4 Aug 2006, p. -.

  Research output: Contribution to conference › Poster › Other research output

• Global gene expression profiling of circulating endothelial cells in patients with metastatic carcinomas

  Smirnov, D. A., Foulk, B. W., Doyle, G. V., Connelly, M. C., Terstappen, L. W. M. M. & O'Hara, S. M., 2006, In: Cancer research. 66, 6, p. 2918-2922

  Research output: Contribution to journal › Article › Academic › peer-review

  • Gene Expression Profiling 100%
  • Metastatic Carcinoma 100%
  • Inpatient 100%
  • Cells 100%
  • Patient 85%
  86 Citations (Scopus)

• Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer

  Cohen, S. J., Alpaugh, R. K., Gross, S., O'Hara, S. M., Smirnov, D. A., Terstappen, L. W. M. M., Allard, W. J., Bilbee, M., Cheng, J. D., Hoffman, J. P., Lewis, N. L., Pellegrino, A., Rogatko, A., Sigurdson, E., Wang, H., Watson, J. C., Weiner, L. M. & Meropol, N. J., 2006, In: Clinical Colorectal Cancer. 6, 2, p. 125-132

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neoplasm 100%
  • Metastatic Colorectal Cancer 100%
  • Flow Cytometry 20%
  • Cytokeratin 13%
  • Colorectal Cancer 13%
  180 Citations (Scopus)