Mireille M.A.E. Claessens

prof.dr.

  • 1276 Citations
  • 20 h-Index
20082019
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Research Output 2008 2019

2019
8 Downloads (Pure)

Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles

Van Lente, J. J., Claessens, M. M. A. E. & Lindhoud, S., 14 Oct 2019, In : Biomacromolecules. 20, 10, p. 3696-3703 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polyelectrolytes
Proteins
Biomolecules
Drug delivery
Liquids
3 Citations (Scopus)
20 Downloads (Pure)

Cooperation of Helix Insertion and Lateral Pressure to Remodel Membranes

Fakhree, M. A. A., Engelbertink, S. A. J., Van Leijenhorst-Groener, K. A., Blum, C. & Claessens, M. M. A. E., 11 Mar 2019, In : Biomacromolecules. 20, 3, p. 1217-1223 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Proteins
Membranes
Synucleins
Compaction
Fusion reactions
7 Citations (Scopus)
68 Downloads (Pure)

Disruptive membrane interactions of alpha-synuclein aggregates

Iyer, A. & Claessens, M. M. A. E., 1 May 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 5, p. 468-482 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Membranes
Parkinson Disease
Phospholipids
Intrinsically Disordered Proteins
9 Downloads (Pure)

Intrinsically disordered protein as carbon nanotube dispersant: How dynamic interactions lead to excellent colloidal stability

Chaudhary, H., Fernandes, R. M. F., Gowda, V., Claessens, M. M. A. E., Furó, I. & Lendel, C., 15 Nov 2019, In : Journal of colloid and interface science. 556, p. 172-179 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Intrinsically Disordered Proteins
Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Carbon nanotubes
20 Downloads (Pure)

Photonic emitter manipulation to sample nanoscale topography

Mateos, N., Molenaar, R., Claessens, M. M. A. E. & Blum, C., 15 Apr 2019, In : Optics express. 27, 8, p. 11698-11708 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
manipulators
topography
emitters
photonics
probes
23 Downloads (Pure)

Shaping membranes with disordered proteins

Fakhree, M. A. A., Blum, C. & Claessens, M. M. A. E., 30 Nov 2019, In : Archives of biochemistry and biophysics. 677, 108163.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Membranes
Membrane Proteins
Proteins
Intrinsically Disordered Proteins
Eukaryota

α-Synuclein Penetrates Mucin Hydrogels despite Its Mucoadhesive Properties

Marczynski, M., Rickert, C. A., Semerdzhiev, S. A., Van Dijk, W. R., Segers-Nolten, I. M. J., Claessens, M. M. A. E. & Lieleg, O., 9 Dec 2019, In : Biomacromolecules. 20, 12, p. 4332-4344 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synucleins
Hydrogels
Mucins
Neurons
Molecules
2018
8 Citations (Scopus)
49 Downloads (Pure)

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells

Fakhree, M. A. A., Nolten, I. S., Blum, C. & Claessens, M. M. A. E., 15 Mar 2018, In : Journal of physical chemistry letters. 9, 6, p. 1249-1253 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Intrinsically Disordered Proteins
Energy transfer
proteins
Proteins
3 Citations (Scopus)
45 Downloads (Pure)

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Hassink, G. C., Raiss, C. C., Segers-Nolten, I. M. J., van Wezel, R. J. A., Subramaniam, V., le Feber, J. & Claessens, M. M. A. E., 22 Mar 2018, In : PLoS ONE. 13, 3, 21 p., e0193763.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
animal communication
Neurons
Rats
Deposits
5 Citations (Scopus)
47 Downloads (Pure)

Hydrophobic-Interaction-Induced Stiffening of α-Synuclein Fibril Networks

Semerdzhiev, S. A., Lindhoud, S., Stefanovic, A., Subramaniam, V., van der Schoot, P. & Claessens, M. M. A. E., 17 May 2018, In : Physical review letters. 120, 20, 6 p., 208102.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stiffening
interactions
elastic properties
enthalpy
deposits
2017

Amyloid micronetworks for cartilage repair

van Dalen, M., Karperien, M., Claessens, M. & Post, J., Apr 2017, In : Osteoarthritis and cartilage. 25, Supplement 1, p. S158-S159 240.

Research output: Contribution to journalMeeting AbstractAcademic

18 Citations (Scopus)
40 Downloads (Pure)

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

Iyer, A., Roeters, S. J., Kogan, V., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 1 Nov 2017, In : Journal of the American Chemical Society. 139, 43, p. 15392-15400 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Amyloid
Circular Dichroism
Polymorphism
Parkinson Disease
7 Citations (Scopus)
57 Downloads (Pure)

Direct Visualization of Model Membrane Remodeling by α-Synuclein Fibrillization

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 20 Jun 2017, In : ChemPhysChem. 18, 12, p. 1620-1626 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Visualization
membranes
Membranes
lipids
12 Citations (Scopus)
83 Downloads (Pure)

Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation

Sidhu, A., Segers-Nolten, G. M. J., Raussens, V., Claessens, M. M. A. E. & Subramaniam, V., 15 Mar 2017, In : ACS chemical neuroscience. 8, 3, p. 538-547

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Polymorphism
Amyloid
Growth
Assays

Lipid Head Group Charge and Fatty Acid Configuration Dictate Liposome Mobility in Neurofilament Networks

Arends, F., Chaudhary, H., Janmey, P., Claessens, M. M. A. E. & Lieleg, O., Feb 2017, In : Macromolecular bioscience. 17, 2, 8 p., 1600229.

Research output: Contribution to journalArticleAcademicpeer-review

Biopolymers
Intermediate Filaments
Liposomes
Fatty acids
Lipids
2 Citations (Scopus)
48 Downloads (Pure)

Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates

Semerdzhiev, S. A., Shvadchak, V. V., Subramaniam, V. & Claessens, M. M. A. E., 1 Dec 2017, In : Scientific reports. 7, 1, 7699.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
self assembly
anisotropy
proteins
biopolymers
polarity
2016
22 Citations (Scopus)
1 Downloads (Pure)

Accumulation of small protein molecules in a macroscopic complex coacervate

Lindhoud, S. & Claessens, M. M. A. E., 2016, In : Soft matter. 12, p. 408-413 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

proteins
Molecules
molecules
Proteins
carbopol 940
13 Citations (Scopus)
51 Downloads (Pure)

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

Raiss, C. C., Braun, T. S., Siemerink-Konings, I. B. M., Grabmayr, H., Hassink, G. C., Sidhu, A., le Feber, J., Bausch, A. R., Jansen, C., Subramaniam, V. & Claessens, M. M. A. E., 17 Mar 2016, In : Scientific reports. 6, 13 p., 23116.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Lewy Bodies
Parkinson Disease
Pathology
Proteasome Endopeptidase Complex
12 Citations (Scopus)
40 Downloads (Pure)

Lysozyme self-assembles into amyloid networks that support cartilage tissue formation

van Dalen, M., Post, J., Karperien, M. & Claessens, M. M. A. E., Apr 2016, In : Osteoarthritis and cartilage. 24, supplement 1, p. S465 794.

Research output: Contribution to journalMeeting AbstractOther research output

Open Access
File
Cartilage
Muramidase
Catalyst supports
Amyloid
Tissue Engineering
11 Citations (Scopus)
44 Downloads (Pure)

Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing

Iyer, A., Schilderink, N., Claessens, M. M. A. E. & Subramaniam, V., 6 Dec 2016, In : Biophysical journal. 111, 11, p. 2440-2449 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Lipids
Membranes
Phospholipids
Synucleins
2 Citations (Scopus)

Monitoring the Switching of Single BSA-ATTO 488 Molecules Covalently End-Attached to a pH-Responsive PAA Brush

Akkilic, N., Molenaar, R., Claessens, M. M. A. E., Blum, C. & de Vos, W. M., 2016, In : Langmuir. 32, 35, p. 8803-8811

Research output: Contribution to journalArticleAcademicpeer-review

brushes
Brushes
Bovine Serum Albumin
albumins
serums

The effect of exogenous human α-synuclein on neuronal network functionality

Hassink, G. C., Raiss, C. C., Claessens, M. M. A. E. & le Feber, J., 24 Jun 2016, p. -.

Research output: Contribution to conferenceAbstract

31 Citations (Scopus)
34 Downloads (Pure)

The Impact of N-terminal Acetylation of alpha-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Iyer, A. S., Roeters, S. J., Schilderink, N., Hommersom, B., Heeren, R. M. A., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 2016, In : Journal of biological chemistry. 291, 40, p. 21110-21122 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Acetylation
alpha-Synuclein
Phospholipids
Membranes
Agglomeration
11 Citations (Scopus)
Synucleins
Membranes
R-SNARE Proteins
Proteins
Protein S
60 Downloads (Pure)

The number of α-synuclein proteins per vesicle gives insights into its physiological function

Abolghassemi Fakhree, M. A., Zijlstra, N., Raiss, C. C., Siero, R., Grabmayr, H., Bausch, A. R., Blum, C. & Claessens, M. M. A. E., 2016, In : Scientific reports. 6, 30658, 30658.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Membranes
Proteins
Protein S
R-SNARE Proteins
7 Citations (Scopus)

α-Synuclein Oligomers Stabilize Pre-Existing Defects in Supported Bilayers and Propagate Membrane Damage in a Fractal-Like Pattern

Chaudhary, H., Iyer, A. S., Subramaniam, V. & Claessens, M. M. A. E., 2016, In : Langmuir. 32, 45, p. 11827-11836

Research output: Contribution to journalArticleAcademicpeer-review

2015
6 Citations (Scopus)

Alpha-Synuclein Amyloid Oligomers Act as Multivalent Nanoparticles to Cause Hemifusion in Negatively Charged Vesicles

Stefanovic, A., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 15 Jan 2015, In : Small. 11, 19, p. 2257-2262

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)
30 Downloads (Pure)

Fibril breaking accelerates α-synuclein fibrillization

Shvadchak, V. V., Claessens, M. M. A. E. & Subramaniam, V., 5 Feb 2015, In : Journal of physical chemistry B. 119, 5, p. 1912-1918 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Agglomeration
monomers
Monomers
Parkinson disease
26 Citations (Scopus)

Oligomers of Parkinson's Disease-Related α-Synuclein Mutants have Similar Structures but Distinctive Membrane Permeabilization Properties

Stefanovic, A. N. D., Lindhoud, S., Semerdzhiev, S. A., Claessens, M. M. A. E. & Subramaniam, V., 2015, In : Biochemistry (USA). 54, p. 3142-3150 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synucleins
Oligomers
Parkinson Disease
Membranes
Mutation
1 Citation (Scopus)

Three Long-Range Distance Constraints and an Approach Towards a Model for the α-Synuclein-Fibril Fold

Hashemi Shabestari, M., Kumar, P., Segers-Nolten, I. M. J., Claessens, M. M. A. E., van Rooijen, B. D., Subramaniam, V. & Huber, M., 2015, In : Applied Magnetic Resonance. 46, 4, p. 369-388 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

strands
Parkinson disease
proteins
paramagnetic resonance
interactions
2014
25 Citations (Scopus)
57 Downloads (Pure)

Amyloids of Alpha-Synuclein Affect the Structure and Dynamics of Supported Lipid Bilayers

Iyer, A. S., Petersen, N. O., Claessens, M. M. A. E. & Subramaniam, V., 2014, In : Biophysical journal. 106, 12, p. 2585-2594 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Lipid Bilayers
Amyloid
Membranes
Lipids

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, J., Blum, C. & Claessens, M. M. A. E., 17 Nov 2014, p. -.

Research output: Contribution to conferencePoster

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, N., Blum, C. & Claessens, M. M. A. E., 29 Sep 2014, p. -.

Research output: Contribution to conferencePoster

Diffraction limited intracellular alpha-synuclein clusters colocalize with cellular membranes

Abolghassemi Fakhree, M. A., Raiss, C. C., Zijlstra, N., Kole, J., Blum, C. & Claessens, M. M. A. E., 22 Sep 2014, p. -.

Research output: Contribution to conferencePoster

13 Citations (Scopus)
12 Downloads (Pure)

Elucidating the Aggregation Number of Dopamine-Induced alpha-Synuclein Oligomeric Assemblies

Zijlstra, N., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 2014, In : Biophysical journal. 106, 2, p. 440-446 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
alpha-Synuclein
Dopamine
Photobleaching
Amyloid
37 Downloads (Pure)

How Do Lipids Localize in Lewy Bodies?

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 17 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 301a-301a

Research output: Contribution to journalArticleAcademicpeer-review

Lewy Bodies
Lipids
Synucleins
Membrane Lipids
Parkinson Disease
32 Downloads (Pure)

Long-Range Distance Constraints for the Fibril Fold of Parkinson's Protein Alpha-Synuclein

Shabestari, M. H., Kumar, P., Segers-Nolten, I. M. J., Claessens, M. M. A. E., van Rooijen, B. D., Subramaniam, V. & Huber, M., 17 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 269a-269a

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Membrane interactions and fibrillization of alpha-synuclein play an essential role in membrane disruption

Chaudhary, H., Stefanovic, A., Subramaniam, V. & Claessens, M. M. A. E., 2014, In : FEBS letters. 588, p. 4457-4463 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

44 Downloads (Pure)
File
33 Citations (Scopus)

Self-Assembly of Protein Fibrils into Suprafibrillar Aggregates: Bridging the Nano- and Mesoscale

Semerdzhiev, S. A., Dekker, D. R., Subramaniam, V. & Claessens, M. M. A. E., 2014, In : ACS nano. 8, 6, p. 5543-5551

Research output: Contribution to journalArticleAcademicpeer-review

24 Downloads (Pure)

The Formation of Higher Order Structures by the Neuronal Protein Alpha-Synuclein: Self-Assembly Over Multiple Length Scales

Semerdzhiev, S. A., Claessens, M. M. A. E. & Subramaniam, V., 19 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 683a-684a

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
40 Downloads (Pure)

α-Synuclein oligomers distinctively permeabilize complex model membranes

Stefanovic, A., Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 2014, In : FEBS Journal. 281, 12, p. 2838-2850 12824.

Research output: Contribution to journalArticleAcademicpeer-review

File
Synucleins
Oligomers
Membranes
Mitochondrial Membranes
Cell Membrane
2013

Alpha-synuclein fibrillization plays essential role in membrane disruption

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 13 Jul 2013, p. -.

Research output: Contribution to conferencePoster

Alpha-synuclein fibrillization plays essential role in membrane disruption

Chaudhary, H., Subramaniam, V. & Claessens, M., 2013, In : European biophysics journal. 42, Suppl. 1, p. S148-S148

Research output: Contribution to journalMeeting AbstractOther research output

Synucleins
alpha-Synuclein
Membranes
Unilamellar Liposomes
Amyloid

Alpha-synuclein oligomers distinctively permeabilize model plasma and mitochondrial membranes

Stefanovic, A., Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 13 Jul 2013, p. -.

Research output: Contribution to conferencePoster

Alpha-synuclein oligomers distinctively permeabilize model plasma and mitochondrial membranes

Stefanovic, A., Claessens, M. M. A. E. & Subramaniam, V., 30 Sep 2013, p. -.

Research output: Contribution to conferencePoster

Alpha-synuclein oligomers distinctively permeabilize model plasma and mitochondrial membranes

Stefanovic, A. N. D., Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 2013, In : European biophysics journal. 42, Suppl. 1, p. S156-S156 P-464.

Research output: Contribution to journalMeeting AbstractOther research output

alpha-Synuclein
Mitochondrial Membranes
Cell Membrane
Artificial Membranes
Membranes

Hierarchical self-assembly of alpha-synuclein

Semerdzhiev, S. A., Dekker, D. R., Lindhoud, S., Subramaniam, V. & Claessens, M. M. A. E., 15 Sep 2013.

Research output: Contribution to conferencePoster