Mireille M.A.E. Claessens

prof.dr.

  • 1274 Citations
  • 20 h-Index
20082019
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Research Output 2008 2019

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Article
2019
6 Downloads (Pure)

Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles

Van Lente, J. J., Claessens, M. M. A. E. & Lindhoud, S., 14 Oct 2019, In : Biomacromolecules. 20, 10, p. 3696-3703 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Polyelectrolytes
Proteins
Biomolecules
Drug delivery
Liquids
3 Citations (Scopus)
19 Downloads (Pure)

Cooperation of Helix Insertion and Lateral Pressure to Remodel Membranes

Fakhree, M. A. A., Engelbertink, S. A. J., Van Leijenhorst-Groener, K. A., Blum, C. & Claessens, M. M. A. E., 11 Mar 2019, In : Biomacromolecules. 20, 3, p. 1217-1223 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Proteins
Membranes
Synucleins
Compaction
Fusion reactions
7 Citations (Scopus)
66 Downloads (Pure)

Disruptive membrane interactions of alpha-synuclein aggregates

Iyer, A. & Claessens, M. M. A. E., 1 May 2019, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 5, p. 468-482 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Membranes
Parkinson Disease
Phospholipids
Intrinsically Disordered Proteins
7 Downloads (Pure)

Intrinsically disordered protein as carbon nanotube dispersant: How dynamic interactions lead to excellent colloidal stability

Chaudhary, H., Fernandes, R. M. F., Gowda, V., Claessens, M. M. A. E., Furó, I. & Lendel, C., 15 Nov 2019, In : Journal of colloid and interface science. 556, p. 172-179 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Intrinsically Disordered Proteins
Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Carbon nanotubes
17 Downloads (Pure)

Photonic emitter manipulation to sample nanoscale topography

Mateos, N., Molenaar, R., Claessens, M. M. A. E. & Blum, C., 15 Apr 2019, In : Optics express. 27, 8, p. 11698-11708 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
manipulators
topography
emitters
photonics
probes

α-Synuclein Penetrates Mucin Hydrogels despite Its Mucoadhesive Properties

Marczynski, M., Rickert, C. A., Semerdzhiev, S. A., Van Dijk, W. R., Segers-Nolten, I. M. J., Claessens, M. M. A. E. & Lieleg, O., 9 Dec 2019, In : Biomacromolecules. 20, 12, p. 4332-4344 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synucleins
Hydrogels
Mucins
Neurons
Molecules
2018
8 Citations (Scopus)
48 Downloads (Pure)

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells

Fakhree, M. A. A., Nolten, I. S., Blum, C. & Claessens, M. M. A. E., 15 Mar 2018, In : Journal of physical chemistry letters. 9, 6, p. 1249-1253 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Intrinsically Disordered Proteins
Energy transfer
proteins
Proteins
3 Citations (Scopus)
44 Downloads (Pure)

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Hassink, G. C., Raiss, C. C., Segers-Nolten, I. M. J., van Wezel, R. J. A., Subramaniam, V., le Feber, J. & Claessens, M. M. A. E., 22 Mar 2018, In : PLoS ONE. 13, 3, 21 p., e0193763.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
animal communication
Neurons
Rats
Deposits
5 Citations (Scopus)
45 Downloads (Pure)

Hydrophobic-Interaction-Induced Stiffening of α-Synuclein Fibril Networks

Semerdzhiev, S. A., Lindhoud, S., Stefanovic, A., Subramaniam, V., van der Schoot, P. & Claessens, M. M. A. E., 17 May 2018, In : Physical review letters. 120, 20, 6 p., 208102.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
stiffening
interactions
elastic properties
enthalpy
deposits
2017
17 Citations (Scopus)
39 Downloads (Pure)

C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

Iyer, A., Roeters, S. J., Kogan, V., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 1 Nov 2017, In : Journal of the American Chemical Society. 139, 43, p. 15392-15400 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Amyloid
Circular Dichroism
Polymorphism
Parkinson Disease
7 Citations (Scopus)
56 Downloads (Pure)

Direct Visualization of Model Membrane Remodeling by α-Synuclein Fibrillization

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 20 Jun 2017, In : ChemPhysChem. 18, 12, p. 1620-1626 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Visualization
membranes
Membranes
lipids
12 Citations (Scopus)
83 Downloads (Pure)

Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation

Sidhu, A., Segers-Nolten, G. M. J., Raussens, V., Claessens, M. M. A. E. & Subramaniam, V., 15 Mar 2017, In : ACS chemical neuroscience. 8, 3, p. 538-547

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Polymorphism
Amyloid
Growth
Assays

Lipid Head Group Charge and Fatty Acid Configuration Dictate Liposome Mobility in Neurofilament Networks

Arends, F., Chaudhary, H., Janmey, P., Claessens, M. M. A. E. & Lieleg, O., Feb 2017, In : Macromolecular bioscience. 17, 2, 8 p., 1600229.

Research output: Contribution to journalArticleAcademicpeer-review

Biopolymers
Intermediate Filaments
Liposomes
Fatty acids
Lipids
2 Citations (Scopus)
45 Downloads (Pure)

Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates

Semerdzhiev, S. A., Shvadchak, V. V., Subramaniam, V. & Claessens, M. M. A. E., 1 Dec 2017, In : Scientific reports. 7, 1, 7699.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
self assembly
anisotropy
proteins
biopolymers
polarity
2016
22 Citations (Scopus)
1 Downloads (Pure)

Accumulation of small protein molecules in a macroscopic complex coacervate

Lindhoud, S. & Claessens, M. M. A. E., 2016, In : Soft matter. 12, p. 408-413 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

proteins
Molecules
molecules
Proteins
carbopol 940
13 Citations (Scopus)
48 Downloads (Pure)

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

Raiss, C. C., Braun, T. S., Siemerink-Konings, I. B. M., Grabmayr, H., Hassink, G. C., Sidhu, A., le Feber, J., Bausch, A. R., Jansen, C., Subramaniam, V. & Claessens, M. M. A. E., 17 Mar 2016, In : Scientific reports. 6, 13 p., 23116.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Lewy Bodies
Parkinson Disease
Pathology
Proteasome Endopeptidase Complex
11 Citations (Scopus)
43 Downloads (Pure)

Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing

Iyer, A., Schilderink, N., Claessens, M. M. A. E. & Subramaniam, V., 6 Dec 2016, In : Biophysical journal. 111, 11, p. 2440-2449 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Lipids
Membranes
Phospholipids
Synucleins
2 Citations (Scopus)

Monitoring the Switching of Single BSA-ATTO 488 Molecules Covalently End-Attached to a pH-Responsive PAA Brush

Akkilic, N., Molenaar, R., Claessens, M. M. A. E., Blum, C. & de Vos, W. M., 2016, In : Langmuir. 32, 35, p. 8803-8811

Research output: Contribution to journalArticleAcademicpeer-review

brushes
Brushes
Bovine Serum Albumin
albumins
serums
31 Citations (Scopus)
33 Downloads (Pure)

The Impact of N-terminal Acetylation of alpha-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Iyer, A. S., Roeters, S. J., Schilderink, N., Hommersom, B., Heeren, R. M. A., Woutersen, S., Claessens, M. M. A. E. & Subramaniam, V., 2016, In : Journal of biological chemistry. 291, 40, p. 21110-21122 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Acetylation
alpha-Synuclein
Phospholipids
Membranes
Agglomeration
59 Downloads (Pure)

The number of α-synuclein proteins per vesicle gives insights into its physiological function

Abolghassemi Fakhree, M. A., Zijlstra, N., Raiss, C. C., Siero, R., Grabmayr, H., Bausch, A. R., Blum, C. & Claessens, M. M. A. E., 2016, In : Scientific reports. 6, 30658, 30658.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Membranes
Proteins
Protein S
R-SNARE Proteins
7 Citations (Scopus)

α-Synuclein Oligomers Stabilize Pre-Existing Defects in Supported Bilayers and Propagate Membrane Damage in a Fractal-Like Pattern

Chaudhary, H., Iyer, A. S., Subramaniam, V. & Claessens, M. M. A. E., 2016, In : Langmuir. 32, 45, p. 11827-11836

Research output: Contribution to journalArticleAcademicpeer-review

2015
6 Citations (Scopus)

Alpha-Synuclein Amyloid Oligomers Act as Multivalent Nanoparticles to Cause Hemifusion in Negatively Charged Vesicles

Stefanovic, A., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 15 Jan 2015, In : Small. 11, 19, p. 2257-2262

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)
28 Downloads (Pure)

Fibril breaking accelerates α-synuclein fibrillization

Shvadchak, V. V., Claessens, M. M. A. E. & Subramaniam, V., 5 Feb 2015, In : Journal of physical chemistry B. 119, 5, p. 1912-1918 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
Agglomeration
monomers
Monomers
Parkinson disease
26 Citations (Scopus)

Oligomers of Parkinson's Disease-Related α-Synuclein Mutants have Similar Structures but Distinctive Membrane Permeabilization Properties

Stefanovic, A. N. D., Lindhoud, S., Semerdzhiev, S. A., Claessens, M. M. A. E. & Subramaniam, V., 2015, In : Biochemistry (USA). 54, p. 3142-3150 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synucleins
Oligomers
Parkinson Disease
Membranes
Mutation
1 Citation (Scopus)

Three Long-Range Distance Constraints and an Approach Towards a Model for the α-Synuclein-Fibril Fold

Hashemi Shabestari, M., Kumar, P., Segers-Nolten, I. M. J., Claessens, M. M. A. E., van Rooijen, B. D., Subramaniam, V. & Huber, M., 2015, In : Applied Magnetic Resonance. 46, 4, p. 369-388 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

strands
Parkinson disease
proteins
paramagnetic resonance
interactions
2014
25 Citations (Scopus)
54 Downloads (Pure)

Amyloids of Alpha-Synuclein Affect the Structure and Dynamics of Supported Lipid Bilayers

Iyer, A. S., Petersen, N. O., Claessens, M. M. A. E. & Subramaniam, V., 2014, In : Biophysical journal. 106, 12, p. 2585-2594 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
alpha-Synuclein
Lipid Bilayers
Amyloid
Membranes
Lipids
13 Citations (Scopus)
11 Downloads (Pure)

Elucidating the Aggregation Number of Dopamine-Induced alpha-Synuclein Oligomeric Assemblies

Zijlstra, N., Claessens, M. M. A. E., Blum, C. & Subramaniam, V., 2014, In : Biophysical journal. 106, 2, p. 440-446 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
alpha-Synuclein
Dopamine
Photobleaching
Amyloid
37 Downloads (Pure)

How Do Lipids Localize in Lewy Bodies?

Chaudhary, H., Subramaniam, V. & Claessens, M. M. A. E., 17 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 301a-301a

Research output: Contribution to journalArticleAcademicpeer-review

Lewy Bodies
Lipids
Synucleins
Membrane Lipids
Parkinson Disease
32 Downloads (Pure)

Long-Range Distance Constraints for the Fibril Fold of Parkinson's Protein Alpha-Synuclein

Shabestari, M. H., Kumar, P., Segers-Nolten, I. M. J., Claessens, M. M. A. E., van Rooijen, B. D., Subramaniam, V. & Huber, M., 17 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 269a-269a

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Membrane interactions and fibrillization of alpha-synuclein play an essential role in membrane disruption

Chaudhary, H., Stefanovic, A., Subramaniam, V. & Claessens, M. M. A. E., 2014, In : FEBS letters. 588, p. 4457-4463 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Self-Assembly of Protein Fibrils into Suprafibrillar Aggregates: Bridging the Nano- and Mesoscale

Semerdzhiev, S. A., Dekker, D. R., Subramaniam, V. & Claessens, M. M. A. E., 2014, In : ACS nano. 8, 6, p. 5543-5551

Research output: Contribution to journalArticleAcademicpeer-review

24 Downloads (Pure)

The Formation of Higher Order Structures by the Neuronal Protein Alpha-Synuclein: Self-Assembly Over Multiple Length Scales

Semerdzhiev, S. A., Claessens, M. M. A. E. & Subramaniam, V., 19 Feb 2014, In : Biophysical journal. 106, 2, Suppl. 1, p. 683a-684a

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
40 Downloads (Pure)

α-Synuclein oligomers distinctively permeabilize complex model membranes

Stefanovic, A., Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 2014, In : FEBS Journal. 281, 12, p. 2838-2850 12824.

Research output: Contribution to journalArticleAcademicpeer-review

File
Synucleins
Oligomers
Membranes
Mitochondrial Membranes
Cell Membrane
2012
22 Citations (Scopus)

Kinetic measurements give new insights into lipid membrane permeabilization by alpha-synuclein oligomers

Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 2012, In : Molecular biosystems. 8, 1, p. 338-345

Research output: Contribution to journalArticleAcademicpeer-review

alpha-Synuclein
Synucleins
Membrane Lipids
Membranes
Intrinsically Disordered Proteins

Molecular Composition of Sub-stoichiometrically Labeled alpha-Synuclein Oligomers Determined by Single-Molecule Photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 2012, In : Angewandte Chemie. 124, 35, p. 8951-8954 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Molecular Composition of Sub-stoichiometrically Labeled alpha-Synuclein Oligomers Determined by Single-Molecule Photobleaching

Zijlstra, N., Blum, C., Segers-Nolten, G. M. J., Claessens, M. M. A. E. & Subramaniam, V., 13 Jul 2012, In : Angewandte Chemie (international edition). 51, 35, p. 8821-8824 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Alpha-synuclein oligomers impair membrane integrity - A mechanistic view

Stöckl, M. T., Claessens, M. M. A. E. & Subramaniam, V., 2011, In : European biophysics journal. 40, 1, p. S93- 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010
34 Citations (Scopus)

Membrane Interactions of Oligomeric Alpha-Synuclein: Potential Role in Parkinson's Disease

van Rooijen, B., Claessens, M. M. A. E. & Subramaniam, V., 2010, In : Current protein & peptide science. 11, p. 334-342 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

86 Citations (Scopus)
60 Downloads (Pure)

Membrane permeabilization by oligomeric α-synuclein: in search of the mechanism

van Rooijen, B., Claessens, M. M. A. E. & Subramaniam, V., 2010, In : PLoS ONE. 5, 12, p. e14292-1-e14292-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Synucleins
dyes
Membranes
Oligomers
Coloring Agents
49 Downloads (Pure)

Structural and functional insights into lipid binding by oligomeric alpha-synuclein

van Rooijen, B., van Leijenhorst-Groener, K. A., Claessens, M. M. A. E. & Subramaniam, V., 2010, In : Biophysical journal. 98, 3, Suppl. 1, p. 653a

Research output: Contribution to journalArticleAcademic

File

Structure and Dynamics of Crosslinked Actin Networks

Lieleg, O., Claessens, M. M. A. E. & Bausch, A. R., 2010, In : Soft matter. 6, p. 218-225 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

145 Citations (Scopus)

Structure and dynamics of cross-linked actin networks

Lieleg, O., Claessens, M. M. A. E. & Bausch, A. R., 2010, In : Soft matter. 6, 2, p. 218-225 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Actins
proteins
Mechanical stability
Proteins
molecular properties
2009
65 Citations (Scopus)
9 Downloads (Pure)

Cytoskeletal Polymer Networks: Viscoelastic Properties are Determined by the Microscopic Interaction Potential of Cross-links

Lieleg, O., Schmoller, K. M., Claessens, M. M. A. E. & Bausch, A. R., 2009, In : Biophysical journal. 96, 3, p. 4725-4732 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actins
Polymers
Microfilament Proteins
Cytoskeleton
Actin Cytoskeleton
103 Citations (Scopus)
45 Downloads (Pure)

Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core

van Rooijen, B., Claessens, M. M. A. E. & Subramaniam, V., 2009, In : Biochimica et biophysica acta. Biomembranes. 1788, 6, p. 1271-1278

Research output: Contribution to journalArticleAcademic

Open Access
File
Synucleins
Lipid bilayers
Lipid Bilayers
Membranes
Lipids
6 Citations (Scopus)

Structural and Viscoelastic Properties of Actin Networks Formed by Espin or Pathologically Relevant Espin Mutants

Lieleg, O., Schmoller, K. M., Purdy Drew, K. R., Claessens, M. M. A. E., Semmrich, C., Zheng, L., Bartles, J. R. & Bausch, A. R., 2009, In : ChemPhysChem. accepted, 16, p. -

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Tryptophan Fluorescence Reveals Structural Features of alpha-synuclein Oligomers

van Rooijen, B., van Leijenhorst-Groener, K. A., Claessens, M. M. A. E. & Subramaniam, V., 2009, In : Journal of molecular biology. accepted, 5, p. -

Research output: Contribution to journalArticleAcademicpeer-review

2008
101 Citations (Scopus)

Cytoskeletal bundle mechanics

Bathe, M., Heussinger, C., Claessens, M. M. A. E., Bausch, A. R. & Frey, E., 2008, In : Biophysical journal. 94, 8, p. 2955-2964 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)
25 Downloads (Pure)

Helical twist controls the thickness of F-actin bundles

Claessens, M. M. A. E., Semmrich, C., Ramos, L. & Bausch, A. R., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 26, p. 8819-8822 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
Actins
Biopolymers
Polymers
Microfilament Proteins
Radiation counters
54 Citations (Scopus)

Membrane binding of oligomeric alpha-synuclein depends on bilayer charge and packing

van Rooijen, B., Claessens, M. M. A. E. & Subramaniam, V., 2008, In : FEBS letters. 582, 27, p. 3788-3792 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Osmotic shrinkage and reswelling of giant vesicles composed of dioleoylphosphatidylglycerol and cholesterol

Claessens, M. M. A. E., Leermakers, F. A. M., Hoekstra, F. A. & Cohen Stuart, M. A., 2008, In : Biochimica et biophysica acta. Biomembranes. 1778, 4, p. 890-895 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cholesterol
Hypertonic Solutions
Membranes
Unilamellar Liposomes
Exponential functions