ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy

T. Auletta, M.R. de Jong, A. Mulder, F.C.J.M. van Veggel, Jurriaan Huskens, David Reinhoudt, S(han) Zou, S.J. Zapotoczny, Holger Schönherr, Gyula J. Vancso, L. Kuipers

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The rupture forces of individual host-guest complexes between ß-cyclodextrin (ß-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1%) were immobilized in mixed monolayers with 2-mercaptoethanol on gold-coated AFM tips. For all guests and for all surface coverages, the force-displacement curves measured between the functionalized tips and monolayers of ß-CD exhibited single, as well as multiple, pull-off events. The histograms of the pull-off forces showed several maxima at equidistant forces, with force quanta characteristic for each guest of 39 ± 15, 45 ± 15, 89 ± 15, and 102 ± 15 pN, respectively. These force quanta were independent of the loading rate, indicating that, because of the fast complexation/decomplexation kinetics, the rupture forces were probed under thermodynamic equilibrium.
Original languageUndefined
Pages (from-to)1577-1584
Number of pages8
JournalJournal of the American Chemical Society
Issue number5
Publication statusPublished - 2004


  • METIS-219123
  • IR-48017

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