ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy

T. Auletta; M.R. de Jong; A. Mulder; F.C.J.M. van Veggel; Jurriaan Huskens; David Reinhoudt; S(han) Zou; S.J. Zapotoczny; Holger Schönherr; G. Julius Vancso; L. Kuipers

doi:10.1021/ja0383569

ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy

T. Auletta
, M.R. de Jong
, A. Mulder
, F.C.J.M. van Veggel
, Jurriaan Huskens
, David Reinhoudt
, S(han) Zou
, S.J. Zapotoczny
, Holger Schönherr
, G. Julius Vancso
, L. Kuipers

Research output: Contribution to journal › Article › Academic › peer-review

152 Citations (Scopus)

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Abstract

The rupture forces of individual host-guest complexes between ß-cyclodextrin (ß-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1%) were immobilized in mixed monolayers with 2-mercaptoethanol on gold-coated AFM tips. For all guests and for all surface coverages, the force-displacement curves measured between the functionalized tips and monolayers of ß-CD exhibited single, as well as multiple, pull-off events. The histograms of the pull-off forces showed several maxima at equidistant forces, with force quanta characteristic for each guest of 39 ± 15, 45 ± 15, 89 ± 15, and 102 ± 15 pN, respectively. These force quanta were independent of the loading rate, indicating that, because of the fast complexation/decomplexation kinetics, the rupture forces were probed under thermodynamic equilibrium.

Original language	English
Pages (from-to)	1577-1584
Number of pages	8
Journal	Journal of the American Chemical Society
Volume	126
Issue number	5
DOIs	https://doi.org/10.1021/ja0383569
Publication status	Published - 2004

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Auletta, T., de Jong, M. R., Mulder, A., van Veggel, F. C. J. M., Huskens, J., Reinhoudt, D., Zou, S., Zapotoczny, S. J., Schönherr, H., Vancso, G. J., & Kuipers, L. (2004). ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy. Journal of the American Chemical Society, 126(5), 1577-1584. https://doi.org/10.1021/ja0383569

@article{85bd53151cfa461488f4bee256bdfdf0,

title = "{\ss}-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy",

abstract = "The rupture forces of individual host-guest complexes between {\ss}-cyclodextrin ({\ss}-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1\%) were immobilized in mixed monolayers with 2-mercaptoethanol on gold-coated AFM tips. For all guests and for all surface coverages, the force-displacement curves measured between the functionalized tips and monolayers of {\ss}-CD exhibited single, as well as multiple, pull-off events. The histograms of the pull-off forces showed several maxima at equidistant forces, with force quanta characteristic for each guest of 39 ± 15, 45 ± 15, 89 ± 15, and 102 ± 15 pN, respectively. These force quanta were independent of the loading rate, indicating that, because of the fast complexation/decomplexation kinetics, the rupture forces were probed under thermodynamic equilibrium.",

author = "T. Auletta and \{de Jong\}, M.R. and A. Mulder and \{van Veggel\}, F.C.J.M. and Jurriaan Huskens and David Reinhoudt and S(han) Zou and S.J. Zapotoczny and Holger Sch{\"o}nherr and Vancso, \{G. Julius\} and L. Kuipers",

year = "2004",

doi = "10.1021/ja0383569",

language = "English",

volume = "126",

pages = "1577--1584",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "5",

}

Auletta, T, de Jong, MR, Mulder, A, van Veggel, FCJM, Huskens, J , Reinhoudt, D, Zou, S, Zapotoczny, SJ, Schönherr, H, Vancso, GJ & Kuipers, L 2004, 'ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy', Journal of the American Chemical Society, vol. 126, no. 5, pp. 1577-1584. https://doi.org/10.1021/ja0383569

TY - JOUR

T1 - ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium

T2 - Thermodynamics and AFM Force Spectroscopy

AU - Auletta, T.

AU - de Jong, M.R.

AU - Mulder, A.

AU - van Veggel, F.C.J.M.

AU - Huskens, Jurriaan

AU - Reinhoudt, David

AU - Zou, S(han)

AU - Zapotoczny, S.J.

AU - Schönherr, Holger

AU - Vancso, G. Julius

AU - Kuipers, L.

PY - 2004

Y1 - 2004

N2 - The rupture forces of individual host-guest complexes between ß-cyclodextrin (ß-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1%) were immobilized in mixed monolayers with 2-mercaptoethanol on gold-coated AFM tips. For all guests and for all surface coverages, the force-displacement curves measured between the functionalized tips and monolayers of ß-CD exhibited single, as well as multiple, pull-off events. The histograms of the pull-off forces showed several maxima at equidistant forces, with force quanta characteristic for each guest of 39 ± 15, 45 ± 15, 89 ± 15, and 102 ± 15 pN, respectively. These force quanta were independent of the loading rate, indicating that, because of the fast complexation/decomplexation kinetics, the rupture forces were probed under thermodynamic equilibrium.

AB - The rupture forces of individual host-guest complexes between ß-cyclodextrin (ß-CD) heptathioether monolayers on Au(111) and several surface-confined guests were measured in aqueous medium by single molecule force spectroscopy using an atomic force microscope. Anilyl, toluidyl, tert-butylphenyl, and adamantylthiols (0.2-1%) were immobilized in mixed monolayers with 2-mercaptoethanol on gold-coated AFM tips. For all guests and for all surface coverages, the force-displacement curves measured between the functionalized tips and monolayers of ß-CD exhibited single, as well as multiple, pull-off events. The histograms of the pull-off forces showed several maxima at equidistant forces, with force quanta characteristic for each guest of 39 ± 15, 45 ± 15, 89 ± 15, and 102 ± 15 pN, respectively. These force quanta were independent of the loading rate, indicating that, because of the fast complexation/decomplexation kinetics, the rupture forces were probed under thermodynamic equilibrium.

U2 - 10.1021/ja0383569

DO - 10.1021/ja0383569

M3 - Article

SN - 0002-7863

VL - 126

SP - 1577

EP - 1584

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 5

ER -

ß-Cyclodextrin Host-Guest Complexes Probed under Thermodynamic Equilibrium: Thermodynamics and AFM Force Spectroscopy

Abstract

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