3D Blood Vessels-on-Chip for atherosclerosis modelling

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Abstract

More than 25% of all deaths worldwide have a direct vascular cause, with coronary artery disease and stroke being two leading causes of death. These two diseases are the direct result of the acute rupture of atherosclerotic plaques in the arterial wall that contain dysfunctional tissue, fats and extracellular matrix. The disease processes in early atherosclerosis are hard to study due to the lack of realistic in vitro models. In this paper we present a 3D blood vessel-on-a-chip model for early atherosclerosis, which includes vascular tissue, cholesterol and immune cells in a patterned extracellular matrix. For the first time, we demonstrate that human iPSC-derived vascular cells take up oxidized LDL (‘bad cholesterol’) in a 3D microfluidic vessel on chip.
Original languageEnglish
Title of host publication25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Subtitle of host publication10-14 October 2021, Palm Springs, CA, USA
Pages16931694
Publication statusPublished - 11 Oct 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States
Duration: 10 Oct 202114 Oct 2021
Conference number: 25
https://microtas2021.org/

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Abbreviated titleMicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs
Period10/10/2114/10/21
Internet address

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