Abstract
More than 25% of all deaths worldwide have a direct vascular cause, with coronary artery disease and stroke being two leading causes of death. These two diseases are the direct result of the acute rupture of atherosclerotic plaques in the arterial wall that contain dysfunctional tissue, fats and extracellular matrix. The disease processes in early atherosclerosis are hard to study due to the lack of realistic in vitro models. In this paper we present a 3D blood vessel-on-a-chip model for early atherosclerosis, which includes vascular tissue, cholesterol and immune cells in a patterned extracellular matrix. For the first time, we demonstrate that human iPSC-derived vascular cells take up oxidized LDL (‘bad cholesterol’) in a 3D microfluidic vessel on chip.
| Original language | English |
|---|---|
| Title of host publication | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Subtitle of host publication | 10-14 October 2021, Palm Springs, CA, USA |
| Pages | 16931694 |
| ISBN (Electronic) | 9781733419031 |
| Publication status | Published - 11 Oct 2021 |
| Event | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States Duration: 10 Oct 2021 → 14 Oct 2021 Conference number: 25 https://microtas2021.org/ |
Publication series
| Name | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 |
|---|---|
| Abbreviated title | MicroTAS 2021 |
| Country/Territory | United States |
| City | Palm Springs |
| Period | 10/10/21 → 14/10/21 |
| Internet address |
Keywords
- atherosclerosis
- blood vessel
- organ on chip
