3D capillary stop valves for versatile patterning inside microfluidic chips

Research output: Contribution to journalArticleAcademicpeer-review

  • 2 Citations

Abstract

The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.
LanguageEnglish
Pages232-238
JournalAnalytica chimica acta
Volume1000
DOIs
Publication statusPublished - 13 Feb 2018

Fingerprint

Microfluidics
antibody
Antibodies
Biomarkers
biomarker
Plasmas
plasma
Fabrication
liquid
Liquids
method

Cite this

@article{87a22a33ceb04c7795ab11f3fc2d3af3,
title = "3D capillary stop valves for versatile patterning inside microfluidic chips",
abstract = "The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.",
author = "Vasileios Papadimitriou and Loes Segerink and {van den Berg}, Albert and Eijkel, {Jan C.T.}",
year = "2018",
month = "2",
day = "13",
doi = "10.1016/j.aca.2017.11.055",
language = "English",
volume = "1000",
pages = "232--238",
journal = "Analytica chimica acta",
issn = "0003-2670",
publisher = "Elsevier",

}

3D capillary stop valves for versatile patterning inside microfluidic chips. / Papadimitriou, Vasileios ; Segerink, Loes; van den Berg, Albert ; Eijkel, Jan C.T.

In: Analytica chimica acta, Vol. 1000, 13.02.2018, p. 232-238.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - 3D capillary stop valves for versatile patterning inside microfluidic chips

AU - Papadimitriou, Vasileios

AU - Segerink, Loes

AU - van den Berg, Albert

AU - Eijkel, Jan C.T.

PY - 2018/2/13

Y1 - 2018/2/13

N2 - The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.

AB - The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.

U2 - 10.1016/j.aca.2017.11.055

DO - 10.1016/j.aca.2017.11.055

M3 - Article

VL - 1000

SP - 232

EP - 238

JO - Analytica chimica acta

T2 - Analytica chimica acta

JF - Analytica chimica acta

SN - 0003-2670

ER -