3D capillary stop valves for versatile patterning inside microfluidic chips

Vasileios Papadimitriou (Corresponding Author), Loes Segerink, Albert van den Berg, Jan C.T. Eijkel

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)
    195 Downloads (Pure)


    The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.
    Original languageEnglish
    Pages (from-to)232-238
    Number of pages7
    JournalAnalytica chimica acta
    Early online date25 Nov 2017
    Publication statusPublished - 13 Feb 2018


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