3D capillary stop valves for versatile patterning inside microfluidic chips

Vasileios Papadimitriou (Corresponding Author), Loes Segerink, Albert van den Berg, Jan C.T. Eijkel

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)
    114 Downloads (Pure)

    Abstract

    The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.
    Original languageEnglish
    Pages (from-to)232-238
    Number of pages7
    JournalAnalytica chimica acta
    Volume1000
    Early online date25 Nov 2017
    DOIs
    Publication statusPublished - 13 Feb 2018

    Fingerprint

    Microfluidics
    antibody
    Antibodies
    Biomarkers
    biomarker
    Plasmas
    plasma
    Fabrication
    liquid
    Liquids
    method

    Cite this

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    title = "3D capillary stop valves for versatile patterning inside microfluidic chips",
    abstract = "The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.",
    author = "Vasileios Papadimitriou and Loes Segerink and {van den Berg}, Albert and Eijkel, {Jan C.T.}",
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    3D capillary stop valves for versatile patterning inside microfluidic chips. / Papadimitriou, Vasileios (Corresponding Author); Segerink, Loes; van den Berg, Albert ; Eijkel, Jan C.T.

    In: Analytica chimica acta, Vol. 1000, 13.02.2018, p. 232-238.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - 3D capillary stop valves for versatile patterning inside microfluidic chips

    AU - Papadimitriou, Vasileios

    AU - Segerink, Loes

    AU - van den Berg, Albert

    AU - Eijkel, Jan C.T.

    PY - 2018/2/13

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    AB - The patterning of antibodies in microfluidics chips is always a delicate process that is usually done in an open chip before bonding. Typical bonding techniques such as plasma treatment can harm the antibodies with as result that they are removed from our fabrication toolbox. Here we propose a method, based on capillary phenomena using 3D capillary valves, that autonomously and conveniently allows us to pattern liquids inside closed chips. We theoretically analyse the system and demonstrate how our analysis can be used as a design tool for various applications. Chips patterned with the method were used for simple immunodetection of a cardiac biomarker which demonstrates its suitability for antibody patterning.

    U2 - 10.1016/j.aca.2017.11.055

    DO - 10.1016/j.aca.2017.11.055

    M3 - Article

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    EP - 238

    JO - Analytica chimica acta

    JF - Analytica chimica acta

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