Abstract
2D neuronal populations coupled to Micro-Electrode-Arrays (MEAs) constitute a well-established experimental in-vitro platform to study neurobiology, network electrophysiology, and basic injury-disease mechanisms. They are also widely used for neuropharmacological screening and neurotoxicity tests. Here we propose a new experimental in-vitro paradigm constituted by 3D engineered networks coupled to both planar and innovative 3D-MEAs. The advantage of such a model is clearly its improved representation of the actual in-vivo environment while maintaining some of the advantages (control, observation) of in-vitro systems. We constructed a physically connected 3D neural network and we demonstrate how the 3D network dynamic differs from the corresponding 2D model, resembling the one detected in the invivo situation. The obtained results suggest new avenues for the use of such 3D models for neurophysiological studies or for the development of biohybrid microsystems for in-vivo neural repair.
Original language | English |
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Title of host publication | 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER) |
Publisher | IEEE |
ISBN (Electronic) | 978-1-4673-1969-0 |
DOIs | |
Publication status | Published - 6 Jan 2014 |
Externally published | Yes |
Event | 6th International IEEE/EMBS Conference on Neural Engineering, NER 2013 - Sheraton San Diego Hotel, San Diego, United States Duration: 6 Nov 2013 → 8 Nov 2013 Conference number: 6 |
Publication series
Name | 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER) |
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Conference
Conference | 6th International IEEE/EMBS Conference on Neural Engineering, NER 2013 |
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Abbreviated title | NER |
Country/Territory | United States |
City | San Diego |
Period | 6/11/13 → 8/11/13 |