3D engineered neural networks coupled to Micro-Electrode based devices: a new experimental model for neurophysiological applications

Mariateresa Tedesco, Monica Frega, Laura Pastorino, Paolo Massobrio, Sergio Martinoia

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Abstract

To study the electrophysiological activity and dynamics of a large neuronal population, Micro-Electrode Array (MEA) based systems are routinely used. 3-D culture models are nowadays considered a way to better mimic the in vivo situation. Here we present a simple approach based on the concept that dissociated cultured neurons are able to grow on micrometric, self-assembled microbeads to form a structurally and functionally connected 3D networks. With this model, we show preliminary results that indicate the possible use of such new experimental system for neuropharmacological studies.
Original languageEnglish
Title of host publication2015 XVIII AISEM Annual Conference
PublisherIEEE
ISBN (Electronic)978-1-4799-8591-3
DOIs
Publication statusPublished - 26 Mar 2015
Externally publishedYes
Event 2015 XVIII AISEM Annual Conference - Trento, Italy
Duration: 3 Feb 20155 Feb 2015

Publication series

Name2015 XVIII AISEM Annual Conference

Conference

Conference 2015 XVIII AISEM Annual Conference
CountryItaly
CityTrento
Period3/02/155/02/15

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