99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans; E. Gommans; F.M. van der Zant; G.J.J. Teule; T.G. van der Schors; J.W.D. de Waard

doi:10.1016/j.apradiso.2009.02.091

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans, E. Gommans, F.M. van der Zant, G.J.J. Teule, T.G. van der Schors, J.W.D. de Waard

Faculty of Science and Technology

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Abstract

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

Original language	English
Pages (from-to)	1550-1558
Journal	Applied radiation and isotopes
Volume	67
Issue number	9
DOIs	https://doi.org/10.1016/j.apradiso.2009.02.091
Publication status	Published - 2009

Keywords

Radiopharmacy
Radiochemical purity
IR-80075
Labelling efficiency
Colloid albumin
Sentinel node

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apradiso.2009.02.091

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@article{79d7984aca3f427286863f3827d75070,

title = "99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results",

abstract = "This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.",

keywords = "Radiopharmacy, Radiochemical purity, IR-80075, Labelling efficiency, Colloid albumin, Sentinel node",

author = "G.M.M. Gommans and E. Gommans and {van der Zant}, F.M. and G.J.J. Teule and {van der Schors}, T.G. and {de Waard}, J.W.D.",

year = "2009",

doi = "10.1016/j.apradiso.2009.02.091",

language = "English",

volume = "67",

pages = "1550--1558",

journal = "Applied radiation and isotopes",

issn = "0969-8043",

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T1 - 99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

AU - Gommans, G.M.M.

AU - Gommans, E.

AU - van der Zant, F.M.

AU - Teule, G.J.J.

AU - van der Schors, T.G.

AU - de Waard, J.W.D.

PY - 2009

Y1 - 2009

N2 - This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

AB - This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

KW - Radiopharmacy

KW - Radiochemical purity

KW - IR-80075

KW - Labelling efficiency

KW - Colloid albumin

KW - Sentinel node

U2 - 10.1016/j.apradiso.2009.02.091

DO - 10.1016/j.apradiso.2009.02.091

M3 - Article

SN - 0969-8043

VL - 67

SP - 1550

EP - 1558

JO - Applied radiation and isotopes

JF - Applied radiation and isotopes

IS - 9

ER -

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

Abstract

Keywords

UN SDGs

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