99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans, E. Gommans, F.M. van der Zant, G.J.J. Teule, T.G. van der Schors, J.W.D. de Waard

Research output: Contribution to journalArticleAcademic

13 Citations (Scopus)

Abstract

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.
Original languageEnglish
Pages (from-to)1550-1558
JournalApplied radiation and isotopes
Volume67
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Radiopharmacy
  • Radiochemical purity
  • IR-80075
  • Labelling efficiency
  • Colloid albumin
  • Sentinel node

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