99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans, E. Gommans, F.M. van der Zant, G.J.J. Teule, T.G. van der Schors, J.W.D. de Waard

Research output: Contribution to journalArticleAcademic

9 Citations (Scopus)

Abstract

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.
Original languageEnglish
Pages (from-to)1550-1558
JournalApplied radiation and isotopes
Volume67
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Radiopharmacy
  • Radiochemical purity
  • IR-80075
  • Labelling efficiency
  • Colloid albumin
  • Sentinel node

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