99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans; E. Gommans; F.M. van der Zant; G.J.J. Teule; T.G. van der Schors; J.W.D. de Waard

doi:10.1016/j.apradiso.2009.02.091

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

G.M.M. Gommans
, E. Gommans
, F.M. van der Zant
, G.J.J. Teule
, T.G. van der Schors
, J.W.D. de Waard

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic

22 Citations (Scopus)

45 Downloads (Pure)

Abstract

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

Original language	English
Pages (from-to)	1550-1558
Journal	Applied radiation and isotopes
Volume	67
Issue number	9
DOIs	https://doi.org/10.1016/j.apradiso.2009.02.091
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Radiopharmacy
Radiochemical purity
IR-80075
Labelling efficiency
Colloid albumin
Sentinel node

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10.1016/j.apradiso.2009.02.091

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title = "99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results",

abstract = "This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.",

keywords = "Radiopharmacy, Radiochemical purity, IR-80075, Labelling efficiency, Colloid albumin, Sentinel node",

author = "G.M.M. Gommans and E. Gommans and \{van der Zant\}, F.M. and G.J.J. Teule and \{van der Schors\}, T.G. and \{de Waard\}, J.W.D.",

year = "2009",

doi = "10.1016/j.apradiso.2009.02.091",

language = "English",

volume = "67",

pages = "1550--1558",

journal = "Applied radiation and isotopes",

issn = "0969-8043",

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TY - JOUR

T1 - 99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

AU - Gommans, G.M.M.

AU - Gommans, E.

AU - van der Zant, F.M.

AU - Teule, G.J.J.

AU - van der Schors, T.G.

AU - de Waard, J.W.D.

PY - 2009

Y1 - 2009

N2 - This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

AB - This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.

KW - Radiopharmacy

KW - Radiochemical purity

KW - IR-80075

KW - Labelling efficiency

KW - Colloid albumin

KW - Sentinel node

U2 - 10.1016/j.apradiso.2009.02.091

DO - 10.1016/j.apradiso.2009.02.091

M3 - Article

SN - 0969-8043

VL - 67

SP - 1550

EP - 1558

JO - Applied radiation and isotopes

JF - Applied radiation and isotopes

IS - 9

ER -

99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer - In vitro and in vivo results

Abstract

UN SDGs

Keywords

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