A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump, Eric P. Visser

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    Abstract

    Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.
    Original languageEnglish
    Article number29
    JournalEJNMMI physics
    Volume3
    DOIs
    Publication statusPublished - Dec 2016

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