A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump, Eric P. Visser

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    Abstract

    Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.
    Original languageEnglish
    Article number29
    JournalEJNMMI physics
    Volume3
    DOIs
    Publication statusPublished - Dec 2016

    Fingerprint

    Single photon emission computed tomography
    pancreas
    kidneys
    Single-Photon Emission-Computed Tomography
    Pancreas
    tomography
    Kidney
    Imaging techniques
    photons
    cells
    Software packages
    Insulin-Secreting Cells
    Software
    computer programs

    Cite this

    Woliner-van der Weg, Wietske ; Deden, Laura N. ; Meeuwis, Antoi P. W. ; Koenrades, Maaike ; Peeters, Laura H. C. ; Kuipers, Henny ; Laanstra, Geert Jan ; Gotthardt, Martin ; Slump, Cornelis H. ; Visser, Eric P. / A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin. In: EJNMMI physics. 2016 ; Vol. 3.
    @article{26fa0aa8373145c4aa7007c8712cb702,
    title = "A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin",
    abstract = "Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.",
    author = "{Woliner-van der Weg}, Wietske and Deden, {Laura N.} and Meeuwis, {Antoi P. W.} and Maaike Koenrades and Peeters, {Laura H. C.} and Henny Kuipers and Laanstra, {Geert Jan} and Martin Gotthardt and Slump, {Cornelis H.} and Visser, {Eric P.}",
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    language = "English",
    volume = "3",
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    A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin. / Woliner-van der Weg, Wietske; Deden, Laura N.; Meeuwis, Antoi P. W.; Koenrades, Maaike; Peeters, Laura H. C.; Kuipers, Henny; Laanstra, Geert Jan; Gotthardt, Martin; Slump, Cornelis H.; Visser, Eric P.

    In: EJNMMI physics, Vol. 3, 29, 12.2016.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Woliner-van der Weg, Wietske

    AU - Deden, Laura N.

    AU - Meeuwis, Antoi P. W.

    AU - Koenrades, Maaike

    AU - Peeters, Laura H. C.

    AU - Kuipers, Henny

    AU - Laanstra, Geert Jan

    AU - Gotthardt, Martin

    AU - Slump, Cornelis H.

    AU - Visser, Eric P.

    PY - 2016/12

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    AB - Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.

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