A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Wietske Woliner-van der Weg, Laura N. Deden, Antoi P. W. Meeuwis, Maaike Koenrades, Laura H. C. Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H. Slump, Eric P. Visser

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Abstract

Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.
Original languageEnglish
Article number29
JournalEJNMMI physics
Volume3
DOIs
Publication statusPublished - Dec 2016

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Single photon emission computed tomography
pancreas
kidneys
Single-Photon Emission-Computed Tomography
Pancreas
tomography
Kidney
Imaging techniques
photons
cells
Software packages
Insulin-Secreting Cells
Software
computer programs

Cite this

Woliner-van der Weg, Wietske ; Deden, Laura N. ; Meeuwis, Antoi P. W. ; Koenrades, Maaike ; Peeters, Laura H. C. ; Kuipers, Henny ; Laanstra, Geert Jan ; Gotthardt, Martin ; Slump, Cornelis H. ; Visser, Eric P. / A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin. In: EJNMMI physics. 2016 ; Vol. 3.
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title = "A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin",
abstract = "Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.",
author = "{Woliner-van der Weg}, Wietske and Deden, {Laura N.} and Meeuwis, {Antoi P. W.} and Maaike Koenrades and Peeters, {Laura H. C.} and Henny Kuipers and Laanstra, {Geert Jan} and Martin Gotthardt and Slump, {Cornelis H.} and Visser, {Eric P.}",
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A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin. / Woliner-van der Weg, Wietske; Deden, Laura N.; Meeuwis, Antoi P. W.; Koenrades, Maaike; Peeters, Laura H. C.; Kuipers, Henny; Laanstra, Geert Jan; Gotthardt, Martin; Slump, Cornelis H.; Visser, Eric P.

In: EJNMMI physics, Vol. 3, 29, 12.2016.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Woliner-van der Weg, Wietske

AU - Deden, Laura N.

AU - Meeuwis, Antoi P. W.

AU - Koenrades, Maaike

AU - Peeters, Laura H. C.

AU - Kuipers, Henny

AU - Laanstra, Geert Jan

AU - Gotthardt, Martin

AU - Slump, Cornelis H.

AU - Visser, Eric P.

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AB - Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.

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DO - 10.1186/s40658-016-0165-0

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