A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Wietske Woliner-van der Weg; Laura N. Deden; Antoi P.W. Meeuwis; Maaike Koenrades; Laura H.C. Peeters; Henny Kuipers; Geert Jan Laanstra; Martin Gotthardt; Cornelis H. Slump; Eric P. Visser

doi:10.1186/s40658-016-0165-0

A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Wietske Woliner-van der Weg
, Laura N. Deden
, Antoi P.W. Meeuwis
, Maaike Koenrades
, Laura H.C. Peeters
, Henny Kuipers
, Geert Jan Laanstra
, Martin Gotthardt
, Cornelis H. Slump
, Eric P. Visser

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.

Original language	English
Article number	29
Journal	EJNMMI physics
Volume	3
DOIs	https://doi.org/10.1186/s40658-016-0165-0
Publication status	Published - Dec 2016

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Woliner-van der Weg, W., Deden, L. N., Meeuwis, A. P. W., Koenrades, M., Peeters, L. H. C., Kuipers, H., Laanstra, G. J., Gotthardt, M., Slump, C. H., & Visser, E. P. (2016). A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin. EJNMMI physics, 3, Article 29. https://doi.org/10.1186/s40658-016-0165-0

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title = "A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin",

abstract = "Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.",

author = "\{Woliner-van der Weg\}, Wietske and Deden, \{Laura N.\} and Meeuwis, \{Antoi P.W.\} and Maaike Koenrades and Peeters, \{Laura H.C.\} and Henny Kuipers and Laanstra, \{Geert Jan\} and Martin Gotthardt and Slump, \{Cornelis H.\} and Visser, \{Eric P.\}",

year = "2016",

month = dec,

doi = "10.1186/s40658-016-0165-0",

language = "English",

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T1 - A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

AU - Woliner-van der Weg, Wietske

AU - Deden, Laura N.

AU - Meeuwis, Antoi P.W.

AU - Koenrades, Maaike

AU - Peeters, Laura H.C.

AU - Kuipers, Henny

AU - Laanstra, Geert Jan

AU - Gotthardt, Martin

AU - Slump, Cornelis H.

AU - Visser, Eric P.

PY - 2016/12

Y1 - 2016/12

N2 - Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.

AB - Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with 111In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages.

U2 - 10.1186/s40658-016-0165-0

DO - 10.1186/s40658-016-0165-0

M3 - Article

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JF - EJNMMI physics

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ER -

A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin

Abstract

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