A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models

N. Picollet-D'hahan, M.E. Dolega, L. Liguori, C. Marquette, Severine le Gac, X. Gidrol, D.K. Martin

    Research output: Contribution to journalArticleAcademicpeer-review

    35 Citations (Scopus)

    Abstract

    We discuss the current challenges and future prospects of flow-based organoid models and 3D self-assembling scaffolds. The existing paradigm of 3D culture suffers from a lack of control over organoid size and shape; can be an obstacle for cell harvesting and extended cellular and molecular analysis; and does not provide access to the function of exocrine glands. Moreover, existing organ-on-chip models are mostly composed of 2D extracellular matrix (ECM)-coated elastomeric membranes that do not mimic real organ architectures. A new comprehensive 3D toolbox for cell biology has emerged to address some of these issues. Advances in microfabrication and cell-culturing approaches enable the engineering of sophisticated models that mimic organ 3D architectures and physiological conditions, while supporting flow-based drug screening and secretomics-based diagnosis.
    Original languageEnglish
    Pages (from-to)757-769
    JournalTrends in biotechnology
    Volume34
    Issue number9
    DOIs
    Publication statusPublished - 2016

    Keywords

    • METIS-321608

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