A Block Copolymer for Functionalisation of Polymersome Surfaces

Stijn van Dongen, Madhavan Nallani, S. Schoffelen, Jeroen Johannes Lambertus Maria Cornelissen, Roeland Nolte, Jan van Hest

Research output: Contribution to journalArticleAcademicpeer-review

72 Citations (Scopus)


A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω-diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this ‘anchor’ compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azido-functionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.
Original languageUndefined
Pages (from-to)321-325
JournalMacromolecular rapid communications
Issue number4 (special issue)
Publication statusPublished - 2008


  • METIS-306466

Cite this