A Block Copolymer for Functionalisation of Polymersome Surfaces

Stijn van Dongen; Madhavan Nallani; S. Schoffelen; Jeroen Johannes Lambertus Maria Cornelissen; Roeland Nolte; Jan van Hest

doi:10.1002/marc.200700765

A Block Copolymer for Functionalisation of Polymersome Surfaces

Stijn van Dongen, Madhavan Nallani, S. Schoffelen, Jeroen Johannes Lambertus Maria Cornelissen, Roeland Nolte, Jan van Hest

Biomolecular Nanotechnology

Research output: Contribution to journal › Article › Academic › peer-review

76 Citations (Scopus)

Abstract

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω-diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this ‘anchor’ compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azido-functionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

Original language	Undefined
Pages (from-to)	321-325
Journal	Macromolecular rapid communications
Volume	29
Issue number	4 (special issue)
DOIs	https://doi.org/10.1002/marc.200700765
Publication status	Published - 2008

Keywords

METIS-306466

Access to Document

10.1002/marc.200700765

Cite this

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AU - van Dongen, Stijn

AU - Nallani, Madhavan

AU - Schoffelen, S.

AU - Cornelissen, Jeroen Johannes Lambertus Maria

AU - Nolte, Roeland

AU - van Hest, Jan

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AB - A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω-diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this ‘anchor’ compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azido-functionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

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JO - Macromolecular rapid communications

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