A capillary micro-reactor as a tool to study pressurized reactions; The influence of pressure on the stereoselectivity of the diels-alder reaction of 2- and 3-furylmethanol with maleimides

F. Benito-Lopez, Albert J. Kettelarij, Richard J.M. Egberink, Aldrik Velders, Roald M. Tiggelaar, Johannes G.E. Gardeniers, David Reinhoudt, Willem Verboom

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

The influence of a pressure of 60 MPa on theconversion and the stereoselectivity of the Diels-Alderreaction of 2- and 3-furylmethanol with methyl-, benzyl-, andphenylmaleimide was studied in a capillary micro-reactor. Inthe case of 2-furylmethanol, a 1.7-fold higher conversion wasobtained at 60 MPa with respect to 0.1 MPa experiments.Pressure positively affects the formation of the exo isomer,whereas in the case of 3-furylmethanol pressure does notaffect the reaction.
Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalChimica oggi = Chemistry today
Volume28
Issue number2
Publication statusPublished - 2010

Keywords

  • IR-94211
  • METIS-268179

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