A cheap 2D fluorescence detection system for μM-sized beads on-chip

Loes I. Segerink, Maarten J. Koster, Ad J. Sprenkels, Istvan Vermes, Albert Van Den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)

Abstract

In this paper a compact fluorescence detection system for on-chip analysis of μm-sized beads is presented. The system comprises a cheap optical pickup with integrated functionalities that are used for the detection. Furthermore some other optical components are added for the fluorescence detection. Another part of the system is the microfluidic chip which contains liquid channels and optical markers used for the autofocus and channel find algorithms. Within one minute the channel of interest is found and fluorescent beads are detected in the microchannel without the need for dynamic focusing, since a two-dimensional scan across the channel width is performed.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages556-558
Number of pages3
Publication statusPublished - 1 Dec 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011 - Seattle, United States
Duration: 2 Oct 20116 Oct 2011
Conference number: 15
https://microtasconferences.org/microtas2011/

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, µTAS 2011
Abbreviated titleMicroTAS
CountryUnited States
CitySeattle
Period2/10/116/10/11
Internet address

Keywords

  • 2D
  • Beads
  • Detection
  • Fluorescence
  • Microfluidic chip
  • Optical markers

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