A clinical feasibility study to evaluate the safety and efficacy of PEOT/PBT implants for human donor site filling during mosaicplasty

Lajos Bartha, Doreen Hamann, Jeroen Pieper, Fabiènne Péters, Jens Riesle, Andras Vajda, Pal Kaposi-Novak, Lazlo Rudolf-Hangody, Gabor Vasarhelyi, Laszlo Bodó, Clemens van Blitterswijk, Joost de Wijn, Annamaria Kenyeres, Laszlo Modis, Eszter Balo, Laszlo Hangody

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Mosaicplasty has become a well-accepted treatment modality for articular cartilage lesions in the knee. Postoperative bleeding remains potentially concerning. This study evaluates the porous poly(ethylene oxide)terephthalate/poly(butylene terephthalate) (PEOT/PBT) implants used for donor site filling. Empty donor sites were the controls. After 9 months, MRI, macroscopical and histological analysis were carried out. Treated defects did not cause postoperative bleeding. No adverse events or inflammatory response was observed. PEOT/PBT implants were well integrated. Empty controls occasionally showed protrusion of repair tissue at the defect margins. Surface stiffness was minimally improved compared to controls. Existing polymer fragments indicated considerable biodegradation. Histological evaluation of the filled donor sites revealed congruent fibrocartilaginous surface repair with proteoglycan-rich domains and subchondral cancellous bone formation with interspersed fibrous tissue in all implanted sites. The PEOT/PBT implants successfully reduce donor site morbidity and postoperative bleeding after mosaicplasty.
Original languageEnglish
Pages (from-to)81-91
JournalEuropean journal of orthopaedic surgery and traumatology
Volume23
Issue number1
DOIs
Publication statusPublished - 6 Dec 2013

Keywords

  • Cartilage
  • Bone remodeling
  • Copolymer
  • In vivo
  • Biocompatibility
  • Biodegradation

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