A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis

C. Smids, Ilse Johanna Elsa Kouijzer, F.J. Vos, T.A. Sprong, A.J.F. Hosman, J.W. de Rooy, E.H.J.G. Aarntzen, Lioe-Fee de Geus-Oei, W.J.G. Oyen, Chantal P. Bleeker-Rovers

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Abstract

Purpose The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. Methods From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if 18F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span. Imaging results were compared to the final clinical diagnosis and follow-up data were collected. Results Sixty-eight patients were included of whom 49 patients were diagnosed with spondylodiscitis. MRI showed an overall sensitivity of 67 % and specificity of 84 %. Diagnostic accuracy was 58 %, when MRI was performed within 2 weeks after the start of symptoms and improved to 82 %, when performed more than 2 weeks after onset of symptoms. 18F-FDG-PET/CT showed a sensitivity of 96 % and a specificity of 95 %, with no relation to the interval between the scan and the start of symptoms. Conclusions As compared to MRI, 18F-FDG-PET/CT has superior diagnostic value for detecting early spondylodiscitis. After 2 weeks both techniques perform similarly.
Original languageEnglish
Pages (from-to)41-49
JournalInfection
Volume45
Issue number1
DOIs
StatePublished - 17 Jun 2017

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Discitis
Fluorodeoxyglucose F18
Magnetic Resonance Imaging
Positron-Emission Tomography
Epidural Abscess
Fever of Unknown Origin
Spine
Tomography
Infection

Keywords

  • IR-101109
  • METIS-317737

Cite this

Smids, C., Kouijzer, I. J. E., Vos, F. J., Sprong, T. A., Hosman, A. J. F., de Rooy, J. W., ... Bleeker-Rovers, C. P. (2017). A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis. 45(1), 41-49. DOI: 10.1007/s15010-016-0914-y

Smids, C.; Kouijzer, Ilse Johanna Elsa; Vos, F.J.; Sprong, T.A.; Hosman, A.J.F.; de Rooy, J.W.; Aarntzen, E.H.J.G.; de Geus-Oei, Lioe-Fee; Oyen, W.J.G.; Bleeker-Rovers, Chantal P. / A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis.

Vol. 45, No. 1, 17.06.2017, p. 41-49.

Research output: Scientific - peer-reviewArticle

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title = "A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis",
abstract = "Purpose The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. Methods From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if 18F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span. Imaging results were compared to the final clinical diagnosis and follow-up data were collected. Results Sixty-eight patients were included of whom 49 patients were diagnosed with spondylodiscitis. MRI showed an overall sensitivity of 67 % and specificity of 84 %. Diagnostic accuracy was 58 %, when MRI was performed within 2 weeks after the start of symptoms and improved to 82 %, when performed more than 2 weeks after onset of symptoms. 18F-FDG-PET/CT showed a sensitivity of 96 % and a specificity of 95 %, with no relation to the interval between the scan and the start of symptoms. Conclusions As compared to MRI, 18F-FDG-PET/CT has superior diagnostic value for detecting early spondylodiscitis. After 2 weeks both techniques perform similarly.",
keywords = "IR-101109, METIS-317737",
author = "C. Smids and Kouijzer, {Ilse Johanna Elsa} and F.J. Vos and T.A. Sprong and A.J.F. Hosman and {de Rooy}, J.W. and E.H.J.G. Aarntzen and {de Geus-Oei}, Lioe-Fee and W.J.G. Oyen and Bleeker-Rovers, {Chantal P.}",
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year = "2017",
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doi = "10.1007/s15010-016-0914-y",
volume = "45",
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Smids, C, Kouijzer, IJE, Vos, FJ, Sprong, TA, Hosman, AJF, de Rooy, JW, Aarntzen, EHJG, de Geus-Oei, L-F, Oyen, WJG & Bleeker-Rovers, CP 2017, 'A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis' vol 45, no. 1, pp. 41-49. DOI: 10.1007/s15010-016-0914-y

A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis. / Smids, C.; Kouijzer, Ilse Johanna Elsa; Vos, F.J.; Sprong, T.A.; Hosman, A.J.F.; de Rooy, J.W.; Aarntzen, E.H.J.G.; de Geus-Oei, Lioe-Fee; Oyen, W.J.G.; Bleeker-Rovers, Chantal P.

Vol. 45, No. 1, 17.06.2017, p. 41-49.

Research output: Scientific - peer-reviewArticle

TY - JOUR

T1 - A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis

AU - Smids,C.

AU - Kouijzer,Ilse Johanna Elsa

AU - Vos,F.J.

AU - Sprong,T.A.

AU - Hosman,A.J.F.

AU - de Rooy,J.W.

AU - Aarntzen,E.H.J.G.

AU - de Geus-Oei,Lioe-Fee

AU - Oyen,W.J.G.

AU - Bleeker-Rovers,Chantal P.

N1 - Open access.

PY - 2017/6/17

Y1 - 2017/6/17

N2 - Purpose The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. Methods From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if 18F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span. Imaging results were compared to the final clinical diagnosis and follow-up data were collected. Results Sixty-eight patients were included of whom 49 patients were diagnosed with spondylodiscitis. MRI showed an overall sensitivity of 67 % and specificity of 84 %. Diagnostic accuracy was 58 %, when MRI was performed within 2 weeks after the start of symptoms and improved to 82 %, when performed more than 2 weeks after onset of symptoms. 18F-FDG-PET/CT showed a sensitivity of 96 % and a specificity of 95 %, with no relation to the interval between the scan and the start of symptoms. Conclusions As compared to MRI, 18F-FDG-PET/CT has superior diagnostic value for detecting early spondylodiscitis. After 2 weeks both techniques perform similarly.

AB - Purpose The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. Methods From January 2006 to August 2013 patients with a clinical suspicion of spondylodiscitis, with an infection, or with fever of unknown origin were retrospectively included if 18F-FDG-PET/CT and MRI of the spine were performed within a 2-week time span. Imaging results were compared to the final clinical diagnosis and follow-up data were collected. Results Sixty-eight patients were included of whom 49 patients were diagnosed with spondylodiscitis. MRI showed an overall sensitivity of 67 % and specificity of 84 %. Diagnostic accuracy was 58 %, when MRI was performed within 2 weeks after the start of symptoms and improved to 82 %, when performed more than 2 weeks after onset of symptoms. 18F-FDG-PET/CT showed a sensitivity of 96 % and a specificity of 95 %, with no relation to the interval between the scan and the start of symptoms. Conclusions As compared to MRI, 18F-FDG-PET/CT has superior diagnostic value for detecting early spondylodiscitis. After 2 weeks both techniques perform similarly.

KW - IR-101109

KW - METIS-317737

U2 - 10.1007/s15010-016-0914-y

DO - 10.1007/s15010-016-0914-y

M3 - Article

VL - 45

SP - 41

EP - 49

IS - 1

ER -

Smids C, Kouijzer IJE, Vos FJ, Sprong TA, Hosman AJF, de Rooy JW et al. A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis. 2017 Jun 17;45(1):41-49. Available from, DOI: 10.1007/s15010-016-0914-y