A Conceptual Framework for Optimizing Blood Matching Strategies: Balancing Patient Complications Against Total Costs Incurred

Joost H.J. van Sambeeck, Puck D. de Wit, Jessie Luken, Barbera Veldhuisen, Katja van den Hurk, Anne van Dongen, Maria M.W. Koopman, Marian G.J. van Kraaij, C. Ellen van der Schoot, Henk Schonewille, Wim L.A.M. de Kort, Mart P. Janssen (Corresponding Author)

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Abstract

Alloimmunization is currently the most frequent adverse blood transfusion event. Whilst completely matched donor blood would nullify the alloimmunization risk, this is practically infeasible. Current matching strategies therefore aim at matching a limited number of blood groups only, and have evolved over time by systematically including matching strategies for those blood groups for which (serious) alloimmunization complications most frequently occurred. An optimal matching strategy for controlling the risk of alloimmunization however, would balance alloimmunization complications and costs within the entire blood supply chain, whilst fulfilling all practical requirements and limitations. In this article the outline of an integrated blood management model is described and various potential challenges and prospects foreseen with the development of such a model are discussed.
Original languageEnglish
Article number199
Number of pages6
JournalFrontiers in medicine
Volume5
DOIs
Publication statusPublished - 25 Jul 2018

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Blood Group Antigens
Complications
Balancing
Blood
Costs and Cost Analysis
Costs
Blood Donors
Blood Transfusion
Model Management
Supply Chain
Strategy
Framework
Entire
Requirements

Keywords

  • Blood supply chain
  • Alloimmunization
  • Cost-effectiveness
  • Optimization
  • Modeling

Cite this

van Sambeeck, Joost H.J. ; de Wit, Puck D. ; Luken, Jessie ; Veldhuisen, Barbera ; van den Hurk, Katja ; van Dongen, Anne ; Koopman, Maria M.W. ; van Kraaij, Marian G.J. ; van der Schoot, C. Ellen ; Schonewille, Henk ; de Kort, Wim L.A.M. ; Janssen, Mart P. / A Conceptual Framework for Optimizing Blood Matching Strategies : Balancing Patient Complications Against Total Costs Incurred. In: Frontiers in medicine. 2018 ; Vol. 5.
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abstract = "Alloimmunization is currently the most frequent adverse blood transfusion event. Whilst completely matched donor blood would nullify the alloimmunization risk, this is practically infeasible. Current matching strategies therefore aim at matching a limited number of blood groups only, and have evolved over time by systematically including matching strategies for those blood groups for which (serious) alloimmunization complications most frequently occurred. An optimal matching strategy for controlling the risk of alloimmunization however, would balance alloimmunization complications and costs within the entire blood supply chain, whilst fulfilling all practical requirements and limitations. In this article the outline of an integrated blood management model is described and various potential challenges and prospects foreseen with the development of such a model are discussed.",
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van Sambeeck, JHJ, de Wit, PD, Luken, J, Veldhuisen, B, van den Hurk, K, van Dongen, A, Koopman, MMW, van Kraaij, MGJ, van der Schoot, CE, Schonewille, H, de Kort, WLAM & Janssen, MP 2018, 'A Conceptual Framework for Optimizing Blood Matching Strategies: Balancing Patient Complications Against Total Costs Incurred' Frontiers in medicine, vol. 5, 199. https://doi.org/10.3389/fmed.2018.00199

A Conceptual Framework for Optimizing Blood Matching Strategies : Balancing Patient Complications Against Total Costs Incurred. / van Sambeeck, Joost H.J.; de Wit, Puck D.; Luken, Jessie; Veldhuisen, Barbera; van den Hurk, Katja; van Dongen, Anne; Koopman, Maria M.W.; van Kraaij, Marian G.J.; van der Schoot, C. Ellen; Schonewille, Henk; de Kort, Wim L.A.M.; Janssen, Mart P. (Corresponding Author).

In: Frontiers in medicine, Vol. 5, 199, 25.07.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T2 - Balancing Patient Complications Against Total Costs Incurred

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AU - de Wit, Puck D.

AU - Luken, Jessie

AU - Veldhuisen, Barbera

AU - van den Hurk, Katja

AU - van Dongen, Anne

AU - Koopman, Maria M.W.

AU - van Kraaij, Marian G.J.

AU - van der Schoot, C. Ellen

AU - Schonewille, Henk

AU - de Kort, Wim L.A.M.

AU - Janssen, Mart P.

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KW - Alloimmunization

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