A fast method for in vivo lactate imaging

T. Reese; D. G. Norris; D. Leibfritz

doi:10.1002/nbm.1940080507

A fast method for in vivo lactate imaging

T. Reese, D. G. Norris, D. Leibfritz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

A robust method for fast lactate imaging is presented using a combination of a lactate editing sequence and a one‐shot imaging experiment. The lactate editing method is based on manipulation of the phase of the lactate CH₃ signal via J‐modulation. This is applied as a preparation experiment to the U‐FLARE imaging sequence. Phantom experiments are presented in which the quality of water and lipid suppression is established. Edited lactate images with a spatial resolution of 3 m̈L and total measuring time of 15.8 min are shown. These were obtained from a hemispherical ischemia in the gerbil brain. The images are compared with diffusion‐weighted water images.

Original language	English
Pages (from-to)	225-231
Number of pages	7
Journal	NMR in biomedicine
Volume	8
Issue number	5
DOIs	https://doi.org/10.1002/nbm.1940080507
Publication status	Published - Aug 1995
Externally published	Yes

Keywords

NLA

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10.1002/nbm.1940080507

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T1 - A fast method for in vivo lactate imaging

AU - Reese, T.

AU - Norris, D. G.

AU - Leibfritz, D.

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N2 - A robust method for fast lactate imaging is presented using a combination of a lactate editing sequence and a one‐shot imaging experiment. The lactate editing method is based on manipulation of the phase of the lactate CH3 signal via J‐modulation. This is applied as a preparation experiment to the U‐FLARE imaging sequence. Phantom experiments are presented in which the quality of water and lipid suppression is established. Edited lactate images with a spatial resolution of 3 m̈L and total measuring time of 15.8 min are shown. These were obtained from a hemispherical ischemia in the gerbil brain. The images are compared with diffusion‐weighted water images.

AB - A robust method for fast lactate imaging is presented using a combination of a lactate editing sequence and a one‐shot imaging experiment. The lactate editing method is based on manipulation of the phase of the lactate CH3 signal via J‐modulation. This is applied as a preparation experiment to the U‐FLARE imaging sequence. Phantom experiments are presented in which the quality of water and lipid suppression is established. Edited lactate images with a spatial resolution of 3 m̈L and total measuring time of 15.8 min are shown. These were obtained from a hemispherical ischemia in the gerbil brain. The images are compared with diffusion‐weighted water images.

KW - NLA

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AN - SCOPUS:0029348507

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VL - 8

SP - 225

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JO - NMR in biomedicine

JF - NMR in biomedicine

IS - 5

ER -

A fast method for in vivo lactate imaging

Abstract

Keywords

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