A computer program was developed that could advice on the choice of solvent and titrant for acid/base titrations in nonaqueous media. It is shown that the feasibility of a titration in a given solvent can be calculated from solvent properties and intrinsic acid/base properties of the sample components. A consistent set of properties for various solvents and a large number of acidic and basic compounds was calculated from literature data with the use of a genetic algorithm. Test results show that the system works well for titrations in various classes of solvents.
Bos, M., & van der Linden, W. E. (1996). A knowledge based advisory system for acid/base titrations in non-aqueous solvents. Analytica chimica acta, 332(332), 201-211. https://doi.org/10.1016/0003-2670(96)00200-0