A maldi-chip integrated system with a monitoring window

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The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalLab on a chip
Issue number4
Publication statusPublished - 2005


  • IR-52542
  • EWI-9985
  • METIS-224142


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