A maldi-chip integrated system with a monitoring window

M. Brivio; Niels Roelof Tas; M.H. Goedbloed; Johannes G.E. Gardeniers; Willem Verboom; Albert van den Berg; David Reinhoudt

doi:10.1039/b418986h

A maldi-chip integrated system with a monitoring window

M. Brivio, Niels Roelof Tas, M.H. Goedbloed, Johannes G.E. Gardeniers, Willem Verboom, Albert van den Berg, David Reinhoudt

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Abstract

The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.

Original language	English
Pages (from-to)	378-381
Number of pages	4
Journal	Lab on a chip
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/b418986h
Publication status	Published - 2005

Keywords

IR-52542
EWI-9985
METIS-224142

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10.1039/b418986h

a_maldi-chip_-_brivio

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title = "A maldi-chip integrated system with a monitoring window",

abstract = "The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.",

keywords = "IR-52542, EWI-9985, METIS-224142",

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T1 - A maldi-chip integrated system with a monitoring window

AU - Brivio, M.

AU - Tas, Niels Roelof

AU - Goedbloed, M.H.

AU - Gardeniers, Johannes G.E.

AU - Verboom, Willem

AU - van den Berg, Albert

AU - Reinhoudt, David

PY - 2005

Y1 - 2005

N2 - The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.

AB - The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the monitoring window approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.

KW - IR-52542

KW - EWI-9985

KW - METIS-224142

U2 - 10.1039/b418986h

DO - 10.1039/b418986h

M3 - Article

SN - 1473-0197

VL - 5

SP - 378

EP - 381

JO - Lab on a chip

JF - Lab on a chip

IS - 4

ER -

A maldi-chip integrated system with a monitoring window

Abstract

Keywords

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