A mathematical model for the leukocyte filtration process

Anton Bruil, Tom Beugeling, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
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Abstract

Leukocyte filters are applied clinically to remove leukocytes from blood. In order to optimize leukocyte filters, a mathematical model to describe the leukocyte filtration process was developed by modification of a general theoretical model for depth filtration. The model presented here can be used to predict the time-dependent leukocyte filtration as a function of cell-cell interaction in the filter, filter efficiency, filter capacity, filter dimensions, and leukocyte concentration in the suspension applied to the filter. The results of different leukocyte filtration experiments previously reported in the literature could be well described by the present model.
Original languageEnglish
Pages (from-to)158-164
JournalBiotechnology and bioengineering
Volume45
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • METIS-105348
  • IR-71200

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