A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Abstract

We report a medium throughput device to study the effects of combinations of two mechanical stimuli – surface strains and fluid flow shear stresses, on cells. The first generation prototype can screen combinations of five strain and five shear stress levels. Computational modeling and empirical measurements were used to determine the generated strains and flows. Uniform equibiaxial strains up to 20% and shear stresses up to 0.3 Pa can be generated. Compatibility of the device with cell culture and end point fixation, staining and imaging is shown using C2C12 mouse myoblast cells.
Original languageEnglish
Pages (from-to)429-439
Number of pages11
JournalLab on a chip
Volume15
Issue number2
DOIs
Publication statusPublished - 31 Oct 2015

Keywords

  • IR-94283
  • METIS-308707
  • EWI-26773

Fingerprint Dive into the research topics of 'A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells'. Together they form a unique fingerprint.

  • Cite this