A Membrane Lung Design Based on Circular Blood Flow Paths

Uditha Piyumindri Fernando; Alex J. Thompson; Joseph Potkay; Hannah Cheriyan; John Toomasian; Andreas Kaesler; Peter Schlanstein; Jutta Arens; Ronald B. Hirschl; Joseph L. Bull; Robert H. Bartlett

doi:10.1097/MAT.0000000000000616

A Membrane Lung Design Based on Circular Blood Flow Paths

Uditha Piyumindri Fernando, Alex J. Thompson, Joseph Potkay, Hannah Cheriyan, John Toomasian, Andreas Kaesler, Peter Schlanstein, Jutta Arens, Ronald B. Hirschl, Joseph L. Bull, Robert H. Bartlett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O₂ transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m² , has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m² . The CO₂ clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO₂ clearance in adults.

Original language	English
Pages (from-to)	637-643
Number of pages	7
Journal	ASAIO Journal
Volume	63
Issue number	5
DOIs	https://doi.org/10.1097/MAT.0000000000000616
Publication status	Published - 1 Jan 2017
Externally published	Yes

Keywords

Artificial lung
Circular flow
Mixing
Oxygenation

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10.1097/MAT.0000000000000616

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title = "A Membrane Lung Design Based on Circular Blood Flow Paths",

abstract = " Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O2 transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m2 , has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m2 . The CO2 clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO2 clearance in adults. ",

keywords = "Artificial lung, Circular flow, Mixing, Oxygenation",

author = "Fernando, {Uditha Piyumindri} and Thompson, {Alex J.} and Joseph Potkay and Hannah Cheriyan and John Toomasian and Andreas Kaesler and Peter Schlanstein and Jutta Arens and Hirschl, {Ronald B.} and Bull, {Joseph L.} and Bartlett, {Robert H.}",

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doi = "10.1097/MAT.0000000000000616",

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AU - Fernando, Uditha Piyumindri

AU - Thompson, Alex J.

AU - Potkay, Joseph

AU - Cheriyan, Hannah

AU - Toomasian, John

AU - Kaesler, Andreas

AU - Schlanstein, Peter

AU - Arens, Jutta

AU - Hirschl, Ronald B.

AU - Bull, Joseph L.

AU - Bartlett, Robert H.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O2 transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m2 , has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m2 . The CO2 clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO2 clearance in adults.

AB - Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O2 transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m2 , has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m2 . The CO2 clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO2 clearance in adults.

KW - Artificial lung

KW - Circular flow

KW - Mixing

KW - Oxygenation

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SN - 1058-2916

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ER -

A Membrane Lung Design Based on Circular Blood Flow Paths

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Keywords

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