A method to identify and screen libraries of guests that complex to a synthetic host

Menno R. de Jong, Ronald M.A. Knegtel, Peter D.J. Grootenhuis, Jurriaan Huskens*, David N. Reinhoudt*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Molecular docking with a large number of guests, followed by experimental verification, was used to determine the selectivity of a synthetic host molecule and resulted in a hit rate of 30 % (see schematic outline of procedure). The identification of ligands for a given receptor by means of screening may represent a paradigm shift in supramolecular host–guest chemistry.
Original languageEnglish
Pages (from-to)1004-1008
JournalAngewandte Chemie, International Edition in English
Volume41
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Cyclodextrin
  • Fluorescence
  • Dansyl group
  • Binding constants

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