A method to identify and screen libraries of guests that complex to a synthetic host

Menno R. de Jong; Ronald M.A. Knegtel; Peter D.J. Grootenhuis; Jurriaan Huskens; David N. Reinhoudt

doi:10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8

A method to identify and screen libraries of guests that complex to a synthetic host

Menno R. de Jong, Ronald M.A. Knegtel, Peter D.J. Grootenhuis, Jurriaan Huskens^*, David N. Reinhoudt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

7 Downloads (Pure)

Abstract

Molecular docking with a large number of guests, followed by experimental verification, was used to determine the selectivity of a synthetic host molecule and resulted in a hit rate of 30 % (see schematic outline of procedure). The identification of ligands for a given receptor by means of screening may represent a paradigm shift in supramolecular host–guest chemistry.

Original language	English
Pages (from-to)	1004-1008
Journal	Angewandte Chemie, International Edition in English
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8
Publication status	Published - 2002

Keywords

Cyclodextrin
Fluorescence
Dansyl group
Binding constants

Access to Document

10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8

Cite this

@article{2950c5993dc6489ba8424790e8faeb05,

title = "A method to identify and screen libraries of guests that complex to a synthetic host",

abstract = "Molecular docking with a large number of guests, followed by experimental verification, was used to determine the selectivity of a synthetic host molecule and resulted in a hit rate of 30 % (see schematic outline of procedure). The identification of ligands for a given receptor by means of screening may represent a paradigm shift in supramolecular host–guest chemistry.",

keywords = "Cyclodextrin, Fluorescence, Dansyl group, Binding constants",

author = "{de Jong}, {Menno R.} and Knegtel, {Ronald M.A.} and Grootenhuis, {Peter D.J.} and Jurriaan Huskens and Reinhoudt, {David N.}",

year = "2002",

doi = "10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8",

language = "English",

volume = "41",

pages = "1004--1008",

journal = "Angewandte Chemie, International Edition in English",

issn = "0570-0833",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - A method to identify and screen libraries of guests that complex to a synthetic host

AU - de Jong, Menno R.

AU - Knegtel, Ronald M.A.

AU - Grootenhuis, Peter D.J.

AU - Huskens, Jurriaan

AU - Reinhoudt, David N.

PY - 2002

Y1 - 2002

N2 - Molecular docking with a large number of guests, followed by experimental verification, was used to determine the selectivity of a synthetic host molecule and resulted in a hit rate of 30 % (see schematic outline of procedure). The identification of ligands for a given receptor by means of screening may represent a paradigm shift in supramolecular host–guest chemistry.

AB - Molecular docking with a large number of guests, followed by experimental verification, was used to determine the selectivity of a synthetic host molecule and resulted in a hit rate of 30 % (see schematic outline of procedure). The identification of ligands for a given receptor by means of screening may represent a paradigm shift in supramolecular host–guest chemistry.

KW - Cyclodextrin

KW - Fluorescence

KW - Dansyl group

KW - Binding constants

U2 - 10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8

DO - 10.1002/1521-3773(20020315)41:6<1004::AID-ANIE1004>3.0.CO;2-8

M3 - Article

SN - 0570-0833

VL - 41

SP - 1004

EP - 1008

JO - Angewandte Chemie, International Edition in English

JF - Angewandte Chemie, International Edition in English

IS - 6

ER -

A method to identify and screen libraries of guests that complex to a synthetic host

Abstract

Keywords

Access to Document

Fingerprint

Cite this