A microfluidic device for monitoring siRNA delivery under fluid now

Andries Dirk van der Meer, J. Feijen (Editor), Marloes Kamphuis, W.E. Hennink (Editor), Andreas A. Poot, A.P. Sam (Editor), Jan Feijen, I. Vermes

Research output: Contribution to conferencePaper

Abstract

When studying particle uptake in vitro, it is favorable to mimic the in vivo situation as much as possible. In this study we present a microfluidic device to mimic the mechanical stress caused by the flow of blood while studying particle uptake in vitro. Human endothelial cells were treated with liposomes containing fluorescent siRNA. It was found that applying physiologically relevant mechanical stress during transfection diminishes the uptake of liposomes in the cells.
Original languageUndefined
Pagese42-e44
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69301
  • METIS-254631

Cite this

van der Meer, A. D., Feijen, J. (Ed.), Kamphuis, M., Hennink, W. E. (Ed.), Poot, A. A., Sam, A. P. (Ed.), ... Vermes, I. (2008). A microfluidic device for monitoring siRNA delivery under fluid now. e42-e44. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.028