A Microfluidic High-Resolution NMR Flow Probe

J. Bart, Ard J. Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J. Nieuwland, Hans (J.W.G.) Janssen, Jan (P.J.M.) van Bentum, Kirsten A.M. Ampt, Floris P.J.T. Rutjes, Sybren S. Wijmenga, Johannes G.E. Gardeniers, Arno P.M. Kentgens

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Abstract

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid
Original languageUndefined
Pages (from-to)5014-5015
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number14
DOIs
Publication statusPublished - 2009

Keywords

  • IR-94223
  • METIS-256949

Cite this

Bart, J., Kolkman, A. J., Oosthoek-de Vries, A. J., Koch, K., Nieuwland, P. J., Janssen, H. J. W. G. ., ... Kentgens, A. P. M. (2009). A Microfluidic High-Resolution NMR Flow Probe. Journal of the American Chemical Society, 131(14), 5014-5015. https://doi.org/10.1021/ja900389x