A Microfluidic High-Resolution NMR Flow Probe

J. Bart, Ard J. Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J. Nieuwland, Hans (J.W.G.) Janssen, Jan (P.J.M.) van Bentum, Kirsten A.M. Ampt, Floris P.J.T. Rutjes, Sybren S. Wijmenga, Johannes G.E. Gardeniers, Arno P.M. Kentgens

Research output: Contribution to journalArticleAcademicpeer-review

100 Citations (Scopus)

Abstract

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid
Original languageUndefined
Pages (from-to)5014-5015
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number14
DOIs
Publication statusPublished - 2009

Keywords

  • IR-94223
  • METIS-256949

Cite this

Bart, J., Kolkman, A. J., Oosthoek-de Vries, A. J., Koch, K., Nieuwland, P. J., Janssen, H. J. W. G. ., ... Kentgens, A. P. M. (2009). A Microfluidic High-Resolution NMR Flow Probe. Journal of the American Chemical Society, 131(14), 5014-5015. https://doi.org/10.1021/ja900389x
Bart, J. ; Kolkman, Ard J. ; Oosthoek-de Vries, Anna Jo ; Koch, Kaspar ; Nieuwland, Pieter J. ; Janssen, Hans (J.W.G.) ; van Bentum, Jan (P.J.M.) ; Ampt, Kirsten A.M. ; Rutjes, Floris P.J.T. ; Wijmenga, Sybren S. ; Gardeniers, Johannes G.E. ; Kentgens, Arno P.M. / A Microfluidic High-Resolution NMR Flow Probe. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 14. pp. 5014-5015.
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abstract = "A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid",
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volume = "131",
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Bart, J, Kolkman, AJ, Oosthoek-de Vries, AJ, Koch, K, Nieuwland, PJ, Janssen, HJWG, van Bentum, JPJM, Ampt, KAM, Rutjes, FPJT, Wijmenga, SS, Gardeniers, JGE & Kentgens, APM 2009, 'A Microfluidic High-Resolution NMR Flow Probe', Journal of the American Chemical Society, vol. 131, no. 14, pp. 5014-5015. https://doi.org/10.1021/ja900389x

A Microfluidic High-Resolution NMR Flow Probe. / Bart, J.; Kolkman, Ard J.; Oosthoek-de Vries, Anna Jo; Koch, Kaspar; Nieuwland, Pieter J.; Janssen, Hans (J.W.G.); van Bentum, Jan (P.J.M.); Ampt, Kirsten A.M.; Rutjes, Floris P.J.T.; Wijmenga, Sybren S.; Gardeniers, Johannes G.E.; Kentgens, Arno P.M.

In: Journal of the American Chemical Society, Vol. 131, No. 14, 2009, p. 5014-5015.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A Microfluidic High-Resolution NMR Flow Probe

AU - Bart, J.

AU - Kolkman, Ard J.

AU - Oosthoek-de Vries, Anna Jo

AU - Koch, Kaspar

AU - Nieuwland, Pieter J.

AU - Janssen, Hans (J.W.G.)

AU - van Bentum, Jan (P.J.M.)

AU - Ampt, Kirsten A.M.

AU - Rutjes, Floris P.J.T.

AU - Wijmenga, Sybren S.

AU - Gardeniers, Johannes G.E.

AU - Kentgens, Arno P.M.

PY - 2009

Y1 - 2009

N2 - A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid

AB - A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid

KW - IR-94223

KW - METIS-256949

U2 - 10.1021/ja900389x

DO - 10.1021/ja900389x

M3 - Article

VL - 131

SP - 5014

EP - 5015

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 14

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Bart J, Kolkman AJ, Oosthoek-de Vries AJ, Koch K, Nieuwland PJ, Janssen HJWG et al. A Microfluidic High-Resolution NMR Flow Probe. Journal of the American Chemical Society. 2009;131(14):5014-5015. https://doi.org/10.1021/ja900389x