A Microfluidic High-Resolution NMR Flow Probe

J. Bart; Ard J. Kolkman; Anna Jo Oosthoek-de Vries; Kaspar Koch; Pieter J. Nieuwland; Hans (J.W.G.) Janssen; Jan (P.J.M.) van Bentum; Kirsten A.M. Ampt; Floris P.J.T. Rutjes; Sybren S. Wijmenga; Johannes G.E. Gardeniers; Arno P.M. Kentgens

doi:10.1021/ja900389x

A Microfluidic High-Resolution NMR Flow Probe

J. Bart, Ard J. Kolkman, Anna Jo Oosthoek-de Vries, Kaspar Koch, Pieter J. Nieuwland, Hans (J.W.G.) Janssen, Jan (P.J.M.) van Bentum, Kirsten A.M. Ampt, Floris P.J.T. Rutjes, Sybren S. Wijmenga, Johannes G.E. Gardeniers, Arno P.M. Kentgens

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Abstract

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid

Original language	Undefined
Pages (from-to)	5014-5015
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	14
DOIs	https://doi.org/10.1021/ja900389x
Publication status	Published - 2009

Keywords

IR-94223
METIS-256949

Access to Document

10.1021/ja900389x

Cite this

@article{36a546aafdb446429454524e004c5450,

title = "A Microfluidic High-Resolution NMR Flow Probe",

abstract = "A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid",

keywords = "IR-94223, METIS-256949",

author = "J. Bart and Kolkman, {Ard J.} and {Oosthoek-de Vries}, {Anna Jo} and Kaspar Koch and Nieuwland, {Pieter J.} and Janssen, {Hans (J.W.G.)} and {van Bentum}, {Jan (P.J.M.)} and Ampt, {Kirsten A.M.} and Rutjes, {Floris P.J.T.} and Wijmenga, {Sybren S.} and Gardeniers, {Johannes G.E.} and Kentgens, {Arno P.M.}",

year = "2009",

doi = "10.1021/ja900389x",

language = "Undefined",

volume = "131",

pages = "5014--5015",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

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TY - JOUR

T1 - A Microfluidic High-Resolution NMR Flow Probe

AU - Bart, J.

AU - Kolkman, Ard J.

AU - Oosthoek-de Vries, Anna Jo

AU - Koch, Kaspar

AU - Nieuwland, Pieter J.

AU - Janssen, Hans (J.W.G.)

AU - van Bentum, Jan (P.J.M.)

AU - Ampt, Kirsten A.M.

AU - Rutjes, Floris P.J.T.

AU - Wijmenga, Sybren S.

AU - Gardeniers, Johannes G.E.

AU - Kentgens, Arno P.M.

PY - 2009

Y1 - 2009

N2 - A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid

AB - A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid

KW - IR-94223

KW - METIS-256949

U2 - 10.1021/ja900389x

DO - 10.1021/ja900389x

M3 - Article

SN - 0002-7863

VL - 131

SP - 5014

EP - 5015

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 14

ER -